Polygenic Profile of Elite Strength Athletes
Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more...
Uloženo v:
| Vydáno v: | Journal of strength and conditioning research Ročník 36; číslo 9; s. 2509 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
01.09.2022
|
| ISSN: | 1533-4287, 1533-4287 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more than 200 DNA polymorphisms associated with strength/power phenotypes have been identified majorly involving nonathletic populations. The aim of the present study was to investigate individually and in combination the association of 217 DNA polymorphisms previously identified as markers for strength/power phenotypes with elite strength athlete status. A case-control study involved 83 Russian professional strength athletes (53 weightlifters, 30 powerlifters), 209 Russian and 503 European controls. Genotyping was conducted using micro-array analysis. Twenty-eight DNA polymorphisms (located near or in ABHD17C , ACTG1 , ADCY3 , ADPGK , ANGPT2 , ARPP21 , BCDIN3D , CRTAC1 , DHODH , GBE1 , IGF1 , IL6 , ITPR1 , KIF1B , LRPPRC , MMS22L , MTHFR , NPIPB6 , PHACTR1 , PLEKHB1 , PPARG , PPARGC1A , R3HDM1 , RASGRF1 , RMC1 , SLC39A8 , TFAP2D , ZKSCAN5 genes) were identified to have an association with strength athlete status. Next, to assess the combined impact of all 28 DNA polymorphisms, all athletes were classified according to the number of "strength" alleles they possessed. All highly elite strength athletes were carriers of at least 22 (up to 34) "strength" alleles, whereas 27.8% of Russian controls had less than 22 "strength" alleles ( p < 0.0001). The proportion of subjects with a high (≥26) number of "strength" alleles was significantly greater in highly elite strength athletes (84.8%) compared with less successful strength athletes (64.9%; odd ratio [OR] = 3.0, p = 0.042), Russian (26.3%; OR = 15.6, p < 0.0001) or European (37.8%; OR = 6.4, p < 0.0001) controls. This is the first study to demonstrate that the likelihood of becoming an elite strength athlete depends on the carriage of a high number of strength-related alleles.ABSTRACTMoreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more than 200 DNA polymorphisms associated with strength/power phenotypes have been identified majorly involving nonathletic populations. The aim of the present study was to investigate individually and in combination the association of 217 DNA polymorphisms previously identified as markers for strength/power phenotypes with elite strength athlete status. A case-control study involved 83 Russian professional strength athletes (53 weightlifters, 30 powerlifters), 209 Russian and 503 European controls. Genotyping was conducted using micro-array analysis. Twenty-eight DNA polymorphisms (located near or in ABHD17C , ACTG1 , ADCY3 , ADPGK , ANGPT2 , ARPP21 , BCDIN3D , CRTAC1 , DHODH , GBE1 , IGF1 , IL6 , ITPR1 , KIF1B , LRPPRC , MMS22L , MTHFR , NPIPB6 , PHACTR1 , PLEKHB1 , PPARG , PPARGC1A , R3HDM1 , RASGRF1 , RMC1 , SLC39A8 , TFAP2D , ZKSCAN5 genes) were identified to have an association with strength athlete status. Next, to assess the combined impact of all 28 DNA polymorphisms, all athletes were classified according to the number of "strength" alleles they possessed. All highly elite strength athletes were carriers of at least 22 (up to 34) "strength" alleles, whereas 27.8% of Russian controls had less than 22 "strength" alleles ( p < 0.0001). The proportion of subjects with a high (≥26) number of "strength" alleles was significantly greater in highly elite strength athletes (84.8%) compared with less successful strength athletes (64.9%; odd ratio [OR] = 3.0, p = 0.042), Russian (26.3%; OR = 15.6, p < 0.0001) or European (37.8%; OR = 6.4, p < 0.0001) controls. This is the first study to demonstrate that the likelihood of becoming an elite strength athlete depends on the carriage of a high number of strength-related alleles. |
|---|---|
| AbstractList | Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more than 200 DNA polymorphisms associated with strength/power phenotypes have been identified majorly involving nonathletic populations. The aim of the present study was to investigate individually and in combination the association of 217 DNA polymorphisms previously identified as markers for strength/power phenotypes with elite strength athlete status. A case-control study involved 83 Russian professional strength athletes (53 weightlifters, 30 powerlifters), 209 Russian and 503 European controls. Genotyping was conducted using micro-array analysis. Twenty-eight DNA polymorphisms (located near or in ABHD17C , ACTG1 , ADCY3 , ADPGK , ANGPT2 , ARPP21 , BCDIN3D , CRTAC1 , DHODH , GBE1 , IGF1 , IL6 , ITPR1 , KIF1B , LRPPRC , MMS22L , MTHFR , NPIPB6 , PHACTR1 , PLEKHB1 , PPARG , PPARGC1A , R3HDM1 , RASGRF1 , RMC1 , SLC39A8 , TFAP2D , ZKSCAN5 genes) were identified to have an association with strength athlete status. Next, to assess the combined impact of all 28 DNA polymorphisms, all athletes were classified according to the number of "strength" alleles they possessed. All highly elite strength athletes were carriers of at least 22 (up to 34) "strength" alleles, whereas 27.8% of Russian controls had less than 22 "strength" alleles ( p < 0.0001). The proportion of subjects with a high (≥26) number of "strength" alleles was significantly greater in highly elite strength athletes (84.8%) compared with less successful strength athletes (64.9%; odd ratio [OR] = 3.0, p = 0.042), Russian (26.3%; OR = 15.6, p < 0.0001) or European (37.8%; OR = 6.4, p < 0.0001) controls. This is the first study to demonstrate that the likelihood of becoming an elite strength athlete depends on the carriage of a high number of strength-related alleles.ABSTRACTMoreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of elite strength athletes. J Strength Cond Res 36(9): 2509-2514, 2022-Strength is a heritable trait with unknown polygenic nature. So far, more than 200 DNA polymorphisms associated with strength/power phenotypes have been identified majorly involving nonathletic populations. The aim of the present study was to investigate individually and in combination the association of 217 DNA polymorphisms previously identified as markers for strength/power phenotypes with elite strength athlete status. A case-control study involved 83 Russian professional strength athletes (53 weightlifters, 30 powerlifters), 209 Russian and 503 European controls. Genotyping was conducted using micro-array analysis. Twenty-eight DNA polymorphisms (located near or in ABHD17C , ACTG1 , ADCY3 , ADPGK , ANGPT2 , ARPP21 , BCDIN3D , CRTAC1 , DHODH , GBE1 , IGF1 , IL6 , ITPR1 , KIF1B , LRPPRC , MMS22L , MTHFR , NPIPB6 , PHACTR1 , PLEKHB1 , PPARG , PPARGC1A , R3HDM1 , RASGRF1 , RMC1 , SLC39A8 , TFAP2D , ZKSCAN5 genes) were identified to have an association with strength athlete status. Next, to assess the combined impact of all 28 DNA polymorphisms, all athletes were classified according to the number of "strength" alleles they possessed. All highly elite strength athletes were carriers of at least 22 (up to 34) "strength" alleles, whereas 27.8% of Russian controls had less than 22 "strength" alleles ( p < 0.0001). The proportion of subjects with a high (≥26) number of "strength" alleles was significantly greater in highly elite strength athletes (84.8%) compared with less successful strength athletes (64.9%; odd ratio [OR] = 3.0, p = 0.042), Russian (26.3%; OR = 15.6, p < 0.0001) or European (37.8%; OR = 6.4, p < 0.0001) controls. This is the first study to demonstrate that the likelihood of becoming an elite strength athlete depends on the carriage of a high number of strength-related alleles. |
| Author | Williams, Alun G Generozov, Edward V Borisov, Oleg V Moreland, Ethan Andryushchenko, Oleg N Larin, Andrey K Ahmetov, Ildus I Andryushchenko, Liliya B Semenova, Ekaterina A |
| Author_xml | – sequence: 1 givenname: Ethan surname: Moreland fullname: Moreland, Ethan – sequence: 2 givenname: Oleg V surname: Borisov fullname: Borisov, Oleg V – sequence: 3 givenname: Ekaterina A surname: Semenova fullname: Semenova, Ekaterina A – sequence: 4 givenname: Andrey K surname: Larin fullname: Larin, Andrey K – sequence: 5 givenname: Oleg N surname: Andryushchenko fullname: Andryushchenko, Oleg N – sequence: 6 givenname: Liliya B surname: Andryushchenko fullname: Andryushchenko, Liliya B – sequence: 7 givenname: Edward V surname: Generozov fullname: Generozov, Edward V – sequence: 8 givenname: Alun G surname: Williams fullname: Williams, Alun G – sequence: 9 givenname: Ildus I surname: Ahmetov fullname: Ahmetov, Ildus I |
| BookMark | eNpNjLFOwzAUAC1UJNrCHzBkZCDFfs924rGKSgFVolJhrhL7uQ0yMcTuwN8zwNBb7qabsckQB2LsVvCFUMI8vOyaBT8DDRcXbCoUYimhriZnfcVmKX1wDkopnLL7bQw_Bxp6W2zH6PtARfTFKvSZil0eaTjkY7HMx0CZ0jW79G1IdPPvOXt_XL01T-Xmdf3cLDellYC87GzltXFdjWjQgKpqajn30nbGOCfrzgknFDeeuLAtcK2cRw-1QatBgYE5u_v7fo3x-0Qp7z_7ZCmEdqB4SnuQutICpZDwCwUxR58 |
| CitedBy_id | crossref_primary_10_3390_genes14061235 crossref_primary_10_3389_fphys_2021_636972 crossref_primary_10_1080_03014460_2021_1919204 crossref_primary_10_5114_jhk_190679 crossref_primary_10_23902_trkjnat_1493225 crossref_primary_10_3390_metabo14120684 crossref_primary_10_3390_genes16050589 crossref_primary_10_3390_genes15121631 crossref_primary_10_1186_s12883_025_04091_x crossref_primary_10_1134_S0022093023060157 crossref_primary_10_3390_genes16091076 crossref_primary_10_3390_sports12110307 crossref_primary_10_3390_sports13020039 crossref_primary_10_3390_sports13060170 crossref_primary_10_3390_genes12101499 crossref_primary_10_1007_s00421_021_04851_w crossref_primary_10_1016_j_jnha_2024_100401 crossref_primary_10_3390_genes13101710 crossref_primary_10_3390_biomedicines10020298 crossref_primary_10_3390_genes13101735 crossref_primary_10_1007_s00421_025_05804_3 crossref_primary_10_1016_j_archger_2024_105553 crossref_primary_10_1016_j_ghir_2024_101627 crossref_primary_10_3389_fonc_2024_1358904 crossref_primary_10_3390_genes15101251 crossref_primary_10_1007_s10519_022_10112_z crossref_primary_10_1007_s13105_025_01071_0 crossref_primary_10_1123_ijspp_2024_0017 crossref_primary_10_1519_JSC_0000000000004634 crossref_primary_10_3390_genes13010025 crossref_primary_10_1007_s12603_021_1665_8 crossref_primary_10_3390_nu15030758 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 National Strength and Conditioning Association. |
| Copyright_xml | – notice: Copyright © 2020 National Strength and Conditioning Association. |
| DBID | 7X8 |
| DOI | 10.1519/JSC.0000000000003901 |
| DatabaseName | MEDLINE - Academic |
| DatabaseTitle | MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Recreation & Sports |
| EISSN | 1533-4287 |
| GroupedDBID | -~X .Z2 01R 0R~ 123 29L 2FS 36B 40H 53G 5AM 5VS 6PF 7O~ 7X8 8R4 8R5 9M8 AAAAV AAAXR AAGIX AAHPQ AAIQE AAJCS AAMOA AAQKA AARTV AASCR AAUEB AAWTL AAXQO ABASU ABBUW ABDIG ABJNI ABNJN ABPXF ABVCZ ABXVJ ABXYN ABZAD ABZZY ACDDN ACDOF ACEWG ACGFO ACGFS ACGOD ACIFK ACILI ACJBD ACLDA ACPRK ACTAD ACTHT ACWDW ACWRI ACXJB ACXNZ ACZKN ADEGP ADGGA ADGHP ADHPY ADKSD ADNVM ADSXY AEBDS AENEX AFBFQ AFDTB AFEXH AFMBP AFNMH AFPHX AFSOK AFYGQ AGINI AHMBA AHOMT AHQNM AHQVU AHVBC AHWXW AIJEX AINUH AJCLO AJEOO AJIOK AJNWD AJZMW AKCTQ AKULP ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AOQMC ATPOU BOYCO BQLVK C45 DIWNM DU5 E.X EBS EEVPB ERAAH EX3 FCALG FL- GNXGY GQDEL HLJTE HZ~ IKREB IKYAY IN~ IPNFZ IYOWL JK3 JK8 KD2 L-C MMDCI MPPUT N~6 N~7 N~B O9- OBZCC ODA ODMTH OGKNY OHYEH OKBHI OLL OPUJH OVD OVDLW OVDNE OVIDH OVLEI OVOZU OXXIT P2P QMB R2J RIG RLZ RWF S4S SJN TEORI TSPGW TWG UMD UPT V2I W3M WF8 WH7 WOQ WOW X3V X3W YQT YR5 ZCA |
| ID | FETCH-LOGICAL-c4230-bc7f69db8339392578ea00f4cb99dd48bd1d1509fe01ca2065df3f2893c625292 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 39 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000843696700020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1533-4287 |
| IngestDate | Thu Oct 02 07:42:11 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4230-bc7f69db8339392578ea00f4cb99dd48bd1d1509fe01ca2065df3f2893c625292 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PQID | 2467613414 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2467613414 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-September-01 |
| PublicationDateYYYYMMDD | 2022-09-01 |
| PublicationDate_xml | – month: 09 year: 2022 text: 2022-September-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Journal of strength and conditioning research |
| PublicationYear | 2022 |
| SSID | ssj0025553 |
| Score | 2.5232162 |
| Snippet | Moreland, E, Borisov, OV, Semenova, EA, Larin, AK, Andryushchenko, ON, Andryushchenko, LB, Generozov, EV, Williams, AG, and Ahmetov, II. Polygenic profile of... |
| SourceID | proquest |
| SourceType | Aggregation Database |
| StartPage | 2509 |
| Title | Polygenic Profile of Elite Strength Athletes |
| URI | https://www.proquest.com/docview/2467613414 |
| Volume | 36 |
| WOSCitedRecordID | wos000843696700020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1JSwMxFA5qPXhxqYo7EcSToWkyS3KSUlpEpBRU6K1ksmhBZtSpgv_el0xqD14E5zwDIfPey_flLR9CF9RIlcOxTrQWiiS8kKRIHSUi03mWMqWYCo3Cd_loJCYTOY4XbnUsq1zExBCoTaX9HXmHgUdnfvpYcv36RrxqlM-uRgmNVdTiAGW8VeeTnywCoOUwhdJDGuKpQWydA9DSub3vN6ML4-Op_69wHM6Y4dZ_V7eNNiO6xL3GHHbQii3bqL2EhvgSB1nzehddjauXL7CemcbjRrcbVw4PfEsy9qnq8mn-jHu-1ALA6B56HA4e-jckSicQDfiIkkLnLpOmEJxLQEDgllZR6hJdSGlMIgrTNQAFpbO0qxUDHGIcd0C-uAZCxCTbR2tlVdoDhIHBap3kmRc_SJjhqkuNE8zAh0KlqT1E54stmYJp-nyDKm31UU-Xm3L0h3eO0QbzrQWhfusEtRy4nz1F6_pzPqvfz8Kf_Qaj0qo6 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Polygenic+Profile+of+Elite+Strength+Athletes&rft.jtitle=Journal+of+strength+and+conditioning+research&rft.au=Moreland%2C+Ethan&rft.au=Borisov%2C+Oleg+V&rft.au=Semenova%2C+Ekaterina+A&rft.au=Larin%2C+Andrey+K&rft.date=2022-09-01&rft.issn=1533-4287&rft.eissn=1533-4287&rft.volume=36&rft.issue=9&rft.spage=2509&rft_id=info:doi/10.1519%2FJSC.0000000000003901&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1533-4287&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1533-4287&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1533-4287&client=summon |