A Fast Approximate Algorithm for Mapping Long Reads to Large Reference Databases

Emerging single-molecule sequencing technologies from Pacific Biosciences and Oxford Nanopore have revived interest in long-read mapping algorithms. Alignment-based seed-and-extend methods demonstrate good accuracy, but face limited scalability, while faster alignment-free methods typically trade de...

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Veröffentlicht in:	Journal of computational biology Jg. 25; H. 7; S. 766
Hauptverfasser:	Jain, Chirag, Dilthey, Alexander, Koren, Sergey, Aluru, Srinivas, Phillippy, Adam M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2018
Schlagworte:	Algorithms Databases, Factual Genome, Human - genetics High-Throughput Nucleotide Sequencing - methods Humans Sequence Alignment - methods Sequence Analysis, DNA Software Jaccard minimizers sketching winnowing MinHash long-read mapping
ISSN:	1557-8666, 1557-8666
Online-Zugang:	Weitere Angaben
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