Topical imiquimod treatment of residual or recurrent cervical intraepithelial neoplasia lesions (TOPIC‐2): A randomised controlled trial

To investigate the efficacy of imiquimod in women with residual or recurrent cervical intraepithelial neoplasia (rrCIN), compared with large loop excision of the transformation zone (LLETZ). Randomised controlled non-inferiority trial. One academic and one regional hospital in the Netherlands. Thirt...

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Bibliographic Details
Published in:	BJOG : an international journal of obstetrics and gynaecology Vol. 132; no. 8; pp. 1056 - 1064
Main Authors:	van de Sande, Anna J. M., van Baars, Romy, Koeneman, Margot M., Gerestein, Cornelis G., Kruse, Arnold‐Jan, van Esch, Edith M. G., de Vos van Steenwijk, Peggy J., Muntinga, Caroline L. P., Willemsen, Sten P., van Doorn, Helena C., van Kemenade, Folkert J., van Beekhuizen, Helene J.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.07.2025 John Wiley and Sons Inc
Subjects:	Administration, Intravaginal Adult Antineoplastic Agents - administration & dosage Cellular biology Cytology Female Human papillomavirus Humans Hysterectomy Imiquimod Imiquimod - administration & dosage Imiquimod - adverse effects Lesions Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neoplasm, Residual - drug therapy Netherlands Papillomavirus Infections Patients Randomised Controlled Trial Side effects Treatment Outcome Uterine Cervical Dysplasia - drug therapy Uterine Cervical Dysplasia - pathology Uterine Cervical Dysplasia - surgery Uterine Cervical Dysplasia - virology Uterine Cervical Neoplasms - drug therapy Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery Uterine Cervical Neoplasms - virology Netherlands high‐grade squamous intraepithelial lesion large loop excision of the transformation zone transformation zone prevention of cervical cancer human papillomavirus imiquimod cervical dysplasia quality of life cervical intraepithelial neoplasia efficacy
ISSN:	1470-0328, 1471-0528, 1471-0528
Online Access:	Get full text
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