Rational design of multi-epitope vaccine for Chandipura virus using an immunoinformatics approach

Chandipura virus (CHPV) is endemic in India, with frequent outbreaks reported. No approved medicines or vaccines exist for CHPV. We aimed to develop a multi-epitope vaccine for CHPV using immunoinformatics approaches. In this study, a multi-epitope vaccine construct was developed by combining 11 CTL...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 10; p. e0335147
Main Authors:	Naderian, Ramtin, Ahmad, Sajjad, Rahmanian, Mojgan, Aghaamoo, Shahrzad, Rahbar, Aryan, Pajand, Omid, Alizadeh, Akram, Nazarian, Shahin, Sanami, Samira, Eslami, Majid
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2025 Public Library of Science (PLoS)
Subjects:	Allergens Animals Antibodies Antigenicity Antigens Bioinformatics Computational Biology - methods COVID-19 vaccines Cytotoxicity Disease transmission Encephalitis Epidemics Epitopes Epitopes, B-Lymphocyte - chemistry Epitopes, B-Lymphocyte - immunology Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Genomes Glycoproteins Humans Immune response Immune system Immunoinformatics Infectious diseases Interferon Interleukin 2 Lymphocytes B Lymphocytes T Molecular docking Molecular Docking Simulation Molecular dynamics Molecular Dynamics Simulation Peptides Protein structure Proteins Rhabdoviridae Infections - immunology Rhabdoviridae Infections - prevention & control TLR4 protein Toll-Like Receptor 4 - chemistry Toll-Like Receptor 4 - immunology Toll-like receptors Toxicity Toxins Vaccines Vesiculovirus - immunology Viral Vaccines - chemistry Viral Vaccines - immunology Viruses India
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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