A window into the brain: multimodal MRI assessment of vascular cognitive impairment

Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer’s disease (AD) in neuro diseases. Th...

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Published in:Frontiers in neuroscience Vol. 19; p. 1526897
Main Authors: Ma, Changjun, Liu, Ailian, Liu, Jiahui, Wang, Xiulin, Cong, Fengyu, Li, Ying, Liu, Jing
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 16.04.2025
Subjects:
diffusion tensor imaging
dynamic functional connectivity
glymphatic system
Neuroscience
resting-state functional MRI
structure–function coupling
vascular cognitive impairment
vascular cognitive impairment
dynamic functional connectivity
diffusion tensor imaging
resting-state functional MRI
structure–function coupling
glymphatic system
ISSN:1662-453X, 1662-4548, 1662-453X
Online Access:Get full text
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Summary:Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer’s disease (AD) in neuro diseases. The advancement of medical imaging technology, particularly magnetic resonance imaging (MRI), has enabled the early detection of structural, functional, metabolic, and cerebral connectivity alterations in individuals with VCI. This paper examines the utility of multimodal MRI in evaluating structural changes in the cerebral cortex, integrity of white matter fiber tracts, alterations in the blood–brain barrier (BBB) and glymphatic system (GS) activity, alteration of neurovascular coupling function, assessment of brain connectivity, and assessment of metabolic changes in patients with VCI.
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Mario Versaci, Mediterranea University of Reggio Calabria, Italy
Reviewed by: Wentai Zhang, Peking Union Medical College Hospital (CAMS), China
Edited by: Ardalan Aarabi, University of Picardie Jules Verne, France
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2025.1526897