A window into the brain: multimodal MRI assessment of vascular cognitive impairment

Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer’s disease (AD) in neuro diseases. Th...

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Vydáno v:Frontiers in neuroscience Ročník 19; s. 1526897
Hlavní autoři: Ma, Changjun, Liu, Ailian, Liu, Jiahui, Wang, Xiulin, Cong, Fengyu, Li, Ying, Liu, Jing
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 16.04.2025
Témata:
diffusion tensor imaging
dynamic functional connectivity
glymphatic system
Neuroscience
resting-state functional MRI
structure–function coupling
vascular cognitive impairment
vascular cognitive impairment
dynamic functional connectivity
diffusion tensor imaging
resting-state functional MRI
structure–function coupling
glymphatic system
ISSN:1662-453X, 1662-4548, 1662-453X
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Shrnutí:Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer’s disease (AD) in neuro diseases. The advancement of medical imaging technology, particularly magnetic resonance imaging (MRI), has enabled the early detection of structural, functional, metabolic, and cerebral connectivity alterations in individuals with VCI. This paper examines the utility of multimodal MRI in evaluating structural changes in the cerebral cortex, integrity of white matter fiber tracts, alterations in the blood–brain barrier (BBB) and glymphatic system (GS) activity, alteration of neurovascular coupling function, assessment of brain connectivity, and assessment of metabolic changes in patients with VCI.
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ObjectType-Review-3
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Mario Versaci, Mediterranea University of Reggio Calabria, Italy
Reviewed by: Wentai Zhang, Peking Union Medical College Hospital (CAMS), China
Edited by: Ardalan Aarabi, University of Picardie Jules Verne, France
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2025.1526897