Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis

Eumycetoma is a neglected tropical subcutaneous disease most commonly caused by the fungus Madurella mycetomatis. Currently, eumycetoma is treated by a combination of antifungal therapy and surgery, with limited success rates. To identify novel drug targets we used an in silico approach to determine...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 19; no. 9; p. e0013482
Main Authors:	Konings, Mickey, Strepis, Nikolaos, Manabe, Ri-Ichiroh, Hasegawa, Akira, Chaudhari, Somdatta, du Pré, Saskia, Schippers, Marij, Tagami, Michihira, Ma, Jingyi, Okazaki, Yasushi, Todd, Matthew, Biersack, Bernhard, Masand, Vijay, Verbon, Annelies, Kasukawa, Takeya, Abugessaisa, Imad, van de Sande, Wendy W. J.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.09.2025 Public Library of Science (PLoS)
Subjects:	Animals Antifungal agents Antifungal Agents - pharmacology Antimicrobial agents Cell Wall - drug effects Cell Wall - enzymology Cell Wall - metabolism Cell walls Datasets Drug development Drugs Fungal Proteins - genetics Fungal Proteins - metabolism Fungi Fungicides Gene expression Genomes Humans Infections Integrity Kinases Madurella - drug effects Madurella - enzymology Madurella - genetics Madurella mycetomatis Moths - microbiology Mycetoma - drug therapy Mycetoma - microbiology Phosphotransferases - genetics Phosphotransferases - metabolism Protein Kinase Inhibitors - pharmacology Proteins Signal Transduction Therapeutic targets Tropical diseases Netherlands
ISSN:	1935-2735, 1935-2727, 1935-2735
Online Access:	Get full text
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