Macrophage metallothioneins participate in the antileishmanial activity of antimonials

Host cell functions that participate in the pharmacokinetics and pharmacodynamics (PK/PD) of drugs against intracellular pathogen infections are critical for drug efficacy. In this study, we investigated whether macrophage mechanisms of xenobiotic detoxification contribute to the elimination of intr...

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Bibliographic Details

Published in:	Frontiers in parasitology Vol. 2
Main Authors:	Vargas, Deninson Alejandro, Gregory, David J., Koren, Roni Nitzan, Zilberstein, Dan, Belew, Ashton Trey, El-Sayed, Najib M., Gómez, María Adelaida
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2023
Subjects:	antimony host-parasite interaction leishmania metal transcription factor-1 (MTF-1) metallothioneins host-parasite interaction antimony metallothioneins leishmania metal transcription factor-1 (MTF-1)
ISSN:	2813-2424, 2813-2424
Online Access:	Get full text
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