The Microbiomes of Pancreatic and Duodenum Tissue Overlap and Are Highly Subject Specific but Differ between Pancreatic Cancer and Noncancer Subjects

In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar withi...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer epidemiology, biomarkers & prevention Vol. 28; no. 2; p. 370
Main Authors:	Del Castillo, Erika, Meier, Richard, Chung, Mei, Koestler, Devin C, Chen, Tsute, Paster, Bruce J, Charpentier, Kevin P, Kelsey, Karl T, Izard, Jacques, Michaud, Dominique S
Format:	Journal Article
Language:	English
Published:	United States 01.02.2019
Subjects:	Aged DNA Barcoding, Taxonomic DNA, Bacterial Duodenum - microbiology Female Fusobacterium Humans Lactobacillus Male Microbiota Middle Aged Pancreas - microbiology Pancreatic Neoplasms - microbiology Rhode Island RNA, Ribosomal, 16S Rhode Island
ISSN:	1538-7755, 1538-7755
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar within individuals. Tissue samples were obtained from 50 subjects with pancreatic cancer or other conditions requiring foregut surgery at the Rhode Island Hospital (RIH), and from 34 organs obtained from the National Disease Research Interchange. 16S rRNA gene sequencing was performed on 189 tissue samples (pancreatic duct, duodenum, pancreas), 57 swabs (bile duct, jejunum, stomach), and 12 stool samples. Pancreatic tissue samples from both sources (RIH and National Disease Research Interchange) had diverse bacterial DNA, including taxa typically identified in the oral cavity. Bacterial DNA across different sites in the pancreas and duodenum were highly subject specific in both cancer and noncancer subjects. Presence of genus was significantly higher in noncancer subjects compared with cancer subjects and the relative abundance of spp., previously associated with colorectal cancer, was higher in cancer subjects compared with noncancer subjects. Bacterial DNA profiles in the pancreas were similar to those in the duodenum tissue of the same subjects, regardless of disease state, suggesting that bacteria may be migrating from the gut into the pancreas. Whether bacteria play a causal role in human pancreatic cancer needs to be further examined. Identifying bacterial taxa that differ in cancer patients can provide new leads on etiologically relevant bacteria.
AbstractList	In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar within individuals.BACKGROUNDIn mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar within individuals.Tissue samples were obtained from 50 subjects with pancreatic cancer or other conditions requiring foregut surgery at the Rhode Island Hospital (RIH), and from 34 organs obtained from the National Disease Research Interchange. 16S rRNA gene sequencing was performed on 189 tissue samples (pancreatic duct, duodenum, pancreas), 57 swabs (bile duct, jejunum, stomach), and 12 stool samples.METHODSTissue samples were obtained from 50 subjects with pancreatic cancer or other conditions requiring foregut surgery at the Rhode Island Hospital (RIH), and from 34 organs obtained from the National Disease Research Interchange. 16S rRNA gene sequencing was performed on 189 tissue samples (pancreatic duct, duodenum, pancreas), 57 swabs (bile duct, jejunum, stomach), and 12 stool samples.Pancreatic tissue samples from both sources (RIH and National Disease Research Interchange) had diverse bacterial DNA, including taxa typically identified in the oral cavity. Bacterial DNA across different sites in the pancreas and duodenum were highly subject specific in both cancer and noncancer subjects. Presence of genus Lactobacillus was significantly higher in noncancer subjects compared with cancer subjects and the relative abundance of Fusobacterium spp., previously associated with colorectal cancer, was higher in cancer subjects compared with noncancer subjects.RESULTSPancreatic tissue samples from both sources (RIH and National Disease Research Interchange) had diverse bacterial DNA, including taxa typically identified in the oral cavity. Bacterial DNA across different sites in the pancreas and duodenum were highly subject specific in both cancer and noncancer subjects. Presence of genus Lactobacillus was significantly higher in noncancer subjects compared with cancer subjects and the relative abundance of Fusobacterium spp., previously associated with colorectal cancer, was higher in cancer subjects compared with noncancer subjects.Bacterial DNA profiles in the pancreas were similar to those in the duodenum tissue of the same subjects, regardless of disease state, suggesting that bacteria may be migrating from the gut into the pancreas. Whether bacteria play a causal role in human pancreatic cancer needs to be further examined.CONCLUSIONSBacterial DNA profiles in the pancreas were similar to those in the duodenum tissue of the same subjects, regardless of disease state, suggesting that bacteria may be migrating from the gut into the pancreas. Whether bacteria play a causal role in human pancreatic cancer needs to be further examined.Identifying bacterial taxa that differ in cancer patients can provide new leads on etiologically relevant bacteria.IMPACTIdentifying bacterial taxa that differ in cancer patients can provide new leads on etiologically relevant bacteria. In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar within individuals. Tissue samples were obtained from 50 subjects with pancreatic cancer or other conditions requiring foregut surgery at the Rhode Island Hospital (RIH), and from 34 organs obtained from the National Disease Research Interchange. 16S rRNA gene sequencing was performed on 189 tissue samples (pancreatic duct, duodenum, pancreas), 57 swabs (bile duct, jejunum, stomach), and 12 stool samples. Pancreatic tissue samples from both sources (RIH and National Disease Research Interchange) had diverse bacterial DNA, including taxa typically identified in the oral cavity. Bacterial DNA across different sites in the pancreas and duodenum were highly subject specific in both cancer and noncancer subjects. Presence of genus was significantly higher in noncancer subjects compared with cancer subjects and the relative abundance of spp., previously associated with colorectal cancer, was higher in cancer subjects compared with noncancer subjects. Bacterial DNA profiles in the pancreas were similar to those in the duodenum tissue of the same subjects, regardless of disease state, suggesting that bacteria may be migrating from the gut into the pancreas. Whether bacteria play a causal role in human pancreatic cancer needs to be further examined. Identifying bacterial taxa that differ in cancer patients can provide new leads on etiologically relevant bacteria.
Author	Chen, Tsute Kelsey, Karl T Izard, Jacques Charpentier, Kevin P Del Castillo, Erika Michaud, Dominique S Koestler, Devin C Meier, Richard Paster, Bruce J Chung, Mei
Author_xml	– sequence: 1 givenname: Erika surname: Del Castillo fullname: Del Castillo, Erika organization: The Forsyth Institute, Cambridge, Massachusetts – sequence: 2 givenname: Richard surname: Meier fullname: Meier, Richard organization: Department of Biostatistics, The University of Kansas Medical Center, Kansas City, Kansas – sequence: 3 givenname: Mei orcidid: 0000-0002-5583-2870 surname: Chung fullname: Chung, Mei organization: Department of Public Health & Community Medicine, Tufts University School of Medicine, Tufts University, Boston, Massachusetts – sequence: 4 givenname: Devin C surname: Koestler fullname: Koestler, Devin C organization: University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas – sequence: 5 givenname: Tsute surname: Chen fullname: Chen, Tsute organization: The Forsyth Institute, Cambridge, Massachusetts – sequence: 6 givenname: Bruce J surname: Paster fullname: Paster, Bruce J organization: Harvard School of Dental Medicine, Boston, Massachusetts – sequence: 7 givenname: Kevin P surname: Charpentier fullname: Charpentier, Kevin P organization: Department of Surgery, Rhode Island Hospital, Providence, Rhode Island – sequence: 8 givenname: Karl T surname: Kelsey fullname: Kelsey, Karl T organization: Department of Epidemiology and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island – sequence: 9 givenname: Jacques orcidid: 0000-0002-5904-5436 surname: Izard fullname: Izard, Jacques organization: School of Biological Sciences, University of Nebraska, Lincoln, Nebraska – sequence: 10 givenname: Dominique S surname: Michaud fullname: Michaud, Dominique S email: Dominique.Michaud@tufts.edu organization: Department of Public Health & Community Medicine, Tufts University School of Medicine, Tufts University, Boston, Massachusetts. Dominique.Michaud@tufts.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30373903$$D View this record in MEDLINE/PubMed
BookMark	eNpNkEtPAjEUhRujkYf-BE2Xbgb7mE6nSwIoJCgk4Jq0nTtSMg-czmj4If5fR8GEzb3n5Jz7LW4PXRZlAQjdUTKgVMSPlAgRKBWJwWQ5C2gcEBGyC9SlgseBlEJcnukO6nm_I4RIJcQ16nDCJVeEd9H3egv4xdmqNK7MweMyxUtd2Ap07SzWRYLHTZlA0eR47bxvAC8-ocr0_i8bVoCn7n2bHfCqMTuwNV7twbq0vTVNjccuTaHCBuovgOKcPGplm_xCXsvCHt2J4W_QVaozD7en3UdvT5P1aBrMF8-z0XAe2JCxOuAxAZXadlIDacQkRErHYQoiCVkiQ2NiqUPClYFEUK0jGktQmlgWighixfro4cjdV-VHA77e5M5byDJdQNn4DaNMUqU4j9rq_anamBySzb5yua4Om_9Xsh_uNHpd
CitedBy_id	crossref_primary_10_1186_s12866_023_03166_4 crossref_primary_10_1016_j_isci_2025_112314 crossref_primary_10_3390_life14080980 crossref_primary_10_3389_fcimb_2022_808991 crossref_primary_10_1016_j_bbcan_2022_188846 crossref_primary_10_1002_cam4_2660 crossref_primary_10_1093_femsre_fuab017 crossref_primary_10_3390_cancers13071748 crossref_primary_10_3390_ijms26010140 crossref_primary_10_1186_s13099_025_00698_0 crossref_primary_10_3389_fvets_2024_1378551 crossref_primary_10_1016_j_surg_2022_10_003 crossref_primary_10_3389_fmicb_2023_1290202 crossref_primary_10_3390_microorganisms11051240 crossref_primary_10_1186_s12935_025_03673_6 crossref_primary_10_1007_s00535_023_02069_5 crossref_primary_10_1080_19490976_2022_2073785 crossref_primary_10_1097_MPA_0000000000002499 crossref_primary_10_1155_2020_4712498 crossref_primary_10_1016_j_cmet_2022_09_001 crossref_primary_10_3389_fimmu_2020_591088 crossref_primary_10_1016_j_semcancer_2025_03_002 crossref_primary_10_1038_s41467_024_51534_z crossref_primary_10_3892_ijo_2024_5640 crossref_primary_10_3390_dj10090156 crossref_primary_10_3390_cancers15092629 crossref_primary_10_3390_diagnostics14090861 crossref_primary_10_1016_j_bbcan_2021_188626 crossref_primary_10_1111_jcpe_13945 crossref_primary_10_1016_j_ccr_2025_216938 crossref_primary_10_1360_SSV_2024_0041 crossref_primary_10_1080_14737159_2023_2281482 crossref_primary_10_3892_br_2025_1932 crossref_primary_10_3390_biomedicines12010227 crossref_primary_10_3390_pathogens14010002 crossref_primary_10_1016_j_jconrel_2025_114196 crossref_primary_10_7717_peerj_19810 crossref_primary_10_3390_jpm12030341 crossref_primary_10_1016_j_canlet_2022_216031 crossref_primary_10_1016_j_jbiomech_2023_111883 crossref_primary_10_1186_s12943_019_1103_2 crossref_primary_10_1002_jhbp_826 crossref_primary_10_3390_ijms26167733 crossref_primary_10_3390_cancers13153784 crossref_primary_10_3390_jcm10245920 crossref_primary_10_4251_wjgo_v15_i5_713 crossref_primary_10_1016_j_neo_2022_100829 crossref_primary_10_1016_j_ccell_2021_08_006 crossref_primary_10_3389_fcimb_2022_871293 crossref_primary_10_1186_s10020_025_01166_w crossref_primary_10_3390_cancers12051068 crossref_primary_10_69709_CIConnect_2025_154988 crossref_primary_10_1097_MPA_0000000000002113 crossref_primary_10_3390_cancers13061231 crossref_primary_10_1186_s13046_025_03313_x crossref_primary_10_3390_ijms231810928 crossref_primary_10_1186_s12866_021_02339_3 crossref_primary_10_1080_19490976_2024_2320280 crossref_primary_10_1371_journal_pone_0283021 crossref_primary_10_1002_cam4_5323 crossref_primary_10_1038_s42255_025_01287_w crossref_primary_10_1016_j_critrevonc_2024_104262 crossref_primary_10_33611_trs_2025_003 crossref_primary_10_1016_j_canlet_2023_216286 crossref_primary_10_3390_microorganisms9050990 crossref_primary_10_1038_s41598_025_00976_6 crossref_primary_10_3748_wjg_v27_i27_4298 crossref_primary_10_1016_j_bbcan_2023_188943 crossref_primary_10_1007_s40496_019_0213_7 crossref_primary_10_1038_s41598_023_37720_x crossref_primary_10_3389_fonc_2022_995357 crossref_primary_10_1016_j_clinre_2020_101589 crossref_primary_10_1186_s40168_022_01262_7 crossref_primary_10_3390_medicina58080978 crossref_primary_10_3390_cancers16234094 crossref_primary_10_3390_microorganisms13010119 crossref_primary_10_3390_ijms222312978 crossref_primary_10_3389_fmicb_2021_641322 crossref_primary_10_1097_CCO_0000000000000927 crossref_primary_10_3390_jcm9113535 crossref_primary_10_7717_peerj_19872 crossref_primary_10_1016_j_cgh_2020_11_006 crossref_primary_10_3389_fmicb_2023_1275374 crossref_primary_10_12998_wjcc_v11_i3_545 crossref_primary_10_1515_sagmb_2019_0027 crossref_primary_10_1007_s12602_024_10437_7 crossref_primary_10_3390_cancers14041020 crossref_primary_10_1016_j_pan_2023_12_010 crossref_primary_10_3390_cancers16020359 crossref_primary_10_3390_cancers13092124 crossref_primary_10_1016_j_gtc_2019_04_008 crossref_primary_10_1038_s41575_019_0242_7 crossref_primary_10_1016_j_pan_2024_08_014 crossref_primary_10_1016_j_tvjl_2024_106145 crossref_primary_10_1136_gutjnl_2021_324755 crossref_primary_10_1007_s00203_024_03914_8 crossref_primary_10_1016_j_semcancer_2021_05_027 crossref_primary_10_1080_15384047_2023_2240084 crossref_primary_10_3389_fmolb_2023_1170181 crossref_primary_10_3390_biom15071018 crossref_primary_10_1080_20002297_2021_1887680 crossref_primary_10_3390_biomedicines11010157 crossref_primary_10_3892_or_2022_8407 crossref_primary_10_1186_s10020_022_00435_2 crossref_primary_10_1016_j_clinsp_2022_100101 crossref_primary_10_1097_JS9_0000000000001762 crossref_primary_10_1016_j_microb_2025_100236 crossref_primary_10_3748_wjg_v28_i32_4527 crossref_primary_10_1016_j_gendis_2025_101733 crossref_primary_10_1111_jcmm_18255 crossref_primary_10_3390_cancers14235974 crossref_primary_10_3389_fonc_2025_1519277 crossref_primary_10_3389_fonc_2020_604531 crossref_primary_10_3390_biom14010059 crossref_primary_10_1038_s41598_022_05554_8 crossref_primary_10_1016_j_ebiom_2024_104967 crossref_primary_10_3390_cancers13143431 crossref_primary_10_1016_j_biopha_2023_115484 crossref_primary_10_3390_cells11121900 crossref_primary_10_1016_j_micres_2022_127082 crossref_primary_10_1097_SLA_0000000000006210 crossref_primary_10_1186_s13578_025_01385_y crossref_primary_10_1080_14737159_2025_2465743 crossref_primary_10_1016_j_semcancer_2021_11_007 crossref_primary_10_1111_prd_12396 crossref_primary_10_3390_cancers15123143 crossref_primary_10_1080_10408363_2019_1615407 crossref_primary_10_3390_nu13124425 crossref_primary_10_1128_spectrum_00962_24 crossref_primary_10_1016_j_bbcan_2020_188484 crossref_primary_10_2478_am_2025_0007 crossref_primary_10_1038_s41416_021_01578_5
ContentType	Journal Article
Copyright	2018 American Association for Cancer Research.
Copyright_xml	– notice: 2018 American Association for Cancer Research.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1158/1055-9965.EPI-18-0542
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1538-7755
ExternalDocumentID	30373903
Genre	Journal Article Research Support, N.I.H., Extramural
GeographicLocations	Rhode Island
GeographicLocations_xml	– name: Rhode Island
GrantInformation_xml	– fundername: NCI NIH HHS grantid: P30 CA168524 – fundername: NCI NIH HHS grantid: R01 CA166150 – fundername: NIGMS NIH HHS grantid: P20 GM103418
GroupedDBID	--- .55 18M 29B 2FS 2WC 34G 39C 3O- 53G 5GY 5VS 6J9 AAJMC ABOCM ACPRK ADBBV ADCOW AENEX AFHIN AFRAH AI. ALMA_UNASSIGNED_HOLDINGS BR6 BTFSW C1A CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FRP H13 H~9 IH2 KQ8 L7B NPM OK1 P2P PQQKQ QTD RCR RHF RHI SJN UDS VH1 W8F WHG WOQ X7M ZXP 7X8 AAFWJ
ID	FETCH-LOGICAL-c422t-380e9fc80e1bef627e69a84fe5d42d74bb87a4039bed51aa6187e9a0c2456e892
IEDL.DBID	7X8
ISICitedReferencesCount	151
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000465321600016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1538-7755
IngestDate	Wed Oct 01 14:59:39 EDT 2025 Thu Jan 02 22:58:56 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	2
Language	English
License	2018 American Association for Cancer Research.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c422t-380e9fc80e1bef627e69a84fe5d42d74bb87a4039bed51aa6187e9a0c2456e892
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ORCID	0000-0002-5904-5436 0000-0002-5583-2870
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/6363867
PMID	30373903
PQID	2127199336
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_2127199336 pubmed_primary_30373903
PublicationCentury	2000
PublicationDate	2019-02-00 20190201
PublicationDateYYYYMMDD	2019-02-01
PublicationDate_xml	– month: 02 year: 2019 text: 2019-02-00
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Cancer epidemiology, biomarkers & prevention
PublicationTitleAlternate	Cancer Epidemiol Biomarkers Prev
PublicationYear	2019
SSID	ssj0007955
Score	2.6197827
Snippet	In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	370
SubjectTerms	Aged DNA Barcoding, Taxonomic DNA, Bacterial Duodenum - microbiology Female Fusobacterium Humans Lactobacillus Male Microbiota Middle Aged Pancreas - microbiology Pancreatic Neoplasms - microbiology Rhode Island RNA, Ribosomal, 16S
Title	The Microbiomes of Pancreatic and Duodenum Tissue Overlap and Are Highly Subject Specific but Differ between Pancreatic Cancer and Noncancer Subjects
URI	https://www.ncbi.nlm.nih.gov/pubmed/30373903 https://www.proquest.com/docview/2127199336
Volume	28
WOSCitedRecordID	wos000465321600016&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA7qinjx_X4QwWt0myZN5iSyDxTcdQ-r7G1JmxQEbdftruAP8f-apBG9CIKXQCkJJZlMvs58mQ-hc6NEAlRQAgwoYVwxklLNidY8MS4DKTwZ8_FO9PtyNIJBCLhVgVb55RO9o9Zl5mLkl66bI5vFydXklTjVKJddDRIai6gRWyjjrFqMvquFC_Cqp35TC8F5uMETcXnpdCGJxfr8ojO4JZEkFrrQ31GmP2266__9zg20FnAmvq4NYxMtmGILrfRCJn0bfVj7wL2nugzTi6lwmeOBtQCPITOsCo3b81I7ojwe-sXB928u9jfx766nBjuKyPM7tq7HxXKwV7LPbd90PsNtr7uCAwvs58gtZ2ZTP0i_LLL6KYxR7aCHbmfYuiFBooFkjNIZiWXTQJ7ZNkpNnlBhElCS5YZrRrVgaSqFYs0YUqN5pFQSSWFANTOXbzUS6C5aKsrC7CPMklyCSiF30h-KKUgTZtEHZBrsT5dgB-jsa8LHdgu4vIYqTDmvxt9TfoD26lUbT-paHWN7QosYmvHhH3ofoVULh6DmZB-jRm4dgDlBy9nb7Kmannrbsm1_0PsEQVvYUg
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Microbiomes+of+Pancreatic+and+Duodenum+Tissue+Overlap+and+Are+Highly+Subject+Specific+but+Differ+between+Pancreatic+Cancer+and+Noncancer+Subjects&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention&rft.au=Del+Castillo%2C+Erika&rft.au=Meier%2C+Richard&rft.au=Chung%2C+Mei&rft.au=Koestler%2C+Devin+C&rft.date=2019-02-01&rft.issn=1538-7755&rft.eissn=1538-7755&rft.volume=28&rft.issue=2&rft.spage=370&rft_id=info:doi/10.1158%2F1055-9965.EPI-18-0542&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1538-7755&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1538-7755&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1538-7755&client=summon