Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide

Hydrogen sulfide (H2S) has a protective role in the pathogenesis of atherosclerosis by multiple pathways. Sirtuin-1 ( ) is a histone deacetylase, as an essential mediated longevity gene, and has an anti-atherogenic effect by regulating the acetylation of some functional proteins. Whether is involved...

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Veröffentlicht in:	Antioxidants & redox signaling Jg. 30; H. 2; S. 184
Hauptverfasser:	Du, Congkuo, Lin, Xianjuan, Xu, Wenjing, Zheng, Fengjiao, Cai, Junyan, Yang, Jichun, Cui, Qinghua, Tang, Chaoshu, Cai, Jun, Xu, Guoheng, Geng, Bin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 10.01.2019
Schlagworte:	Acetylation Animals Apolipoproteins E - deficiency Atherosclerosis - drug therapy Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Biomarkers Cell Line Cholesterol - metabolism Disease Models, Animal Endothelium - metabolism Epigenesis, Genetic Foam Cells - metabolism Foam Cells - pathology Gene Expression Humans Hydrogen Sulfide - pharmacology Immunohistochemistry Mice Mice, Knockout Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - etiology Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Protein Processing, Post-Translational Sirtuin 1 - genetics Sirtuin 1 - metabolism Ubiquitination atherosclerosis sirtuin1 sulfhydration hydrogen sulfide cystathionine gamma lyase
ISSN:	1557-7716, 1557-7716
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