In Vogue: Ketamine for Neuroprotection in Acute Neurologic Injury

Neurologic deterioration following acute injury to the central nervous system may be amenable to pharmacologic intervention, although, to date, no such therapy exists. Ketamine is an anesthetic and analgesic emerging as a novel therapy for a number of clinical entities in recent years, including ref...

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Bibliographic Details
Published in:Anesthesia and analgesia Vol. 124; no. 4; p. 1237
Main Author: Bell, Josh D
Format: Journal Article
Language:English
Published: United States 01.04.2017
Subjects:
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Apoptosis - drug effects
Apoptosis - physiology
Humans
Ketamine - pharmacology
Ketamine - therapeutic use
Neuroprotection - drug effects
Neuroprotection - physiology
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Thrombosis - diagnosis
Thrombosis - prevention & control
Trauma, Nervous System - diagnosis
Trauma, Nervous System - prevention & control
ISSN:1526-7598, 1526-7598
Online Access:Get more information
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Summary:Neurologic deterioration following acute injury to the central nervous system may be amenable to pharmacologic intervention, although, to date, no such therapy exists. Ketamine is an anesthetic and analgesic emerging as a novel therapy for a number of clinical entities in recent years, including refractory pain, depression, and drug-induced hyperalgesia due to newly discovered mechanisms of action and new application of its known pharmacodynamics. In this focused review, the evidence for ketamine as a neuroprotective agent in stroke, neurotrauma, subarachnoid hemorrhage, and status epilepticus is highlighted, with a focus on its applications for excitotoxicity, neuroinflammation, and neuronal hyperexcitability. Preclinical modeling and clinical applications are discussed.
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ISSN:1526-7598
1526-7598
DOI:10.1213/ANE.0000000000001856