The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update
Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date guidance for the management of HAE. For this update and revi...
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| Vydané v: | Allergy (Copenhagen) Ročník 77; číslo 7; s. 1961 - 1990 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Denmark
Blackwell Publishing Ltd
01.07.2022
Wiley |
| Predmet: | |
| ISSN: | 0105-4538, 1398-9995, 1398-9995 |
| On-line prístup: | Získať plný text |
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| Abstract | Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on‐demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast‐feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients. |
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| AbstractList | Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on‐demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast‐feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients. Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up-to-date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on-demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast-feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients.Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up-to-date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on-demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast-feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients. Abstract Hereditary angioedema (HAE) is a rare and disabling disease for which early diagnosis and effective therapy are critical. This revision and update of the global WAO/EAACI guideline on the diagnosis and management of HAE provides up‐to‐date guidance for the management of HAE. For this update and revision of the guideline, an international panel of experts reviewed the existing evidence, developed 28 recommendations, and established consensus by an online DELPHI process. The goal of these recommendations and guideline is to help physicians and their patients in making rational decisions in the management of HAE with deficient C1 inhibitor (type 1) and HAE with dysfunctional C1 inhibitor (type 2), by providing guidance on common and important clinical issues, such as: (1) How should HAE be diagnosed? (2) When should HAE patients receive prophylactic on top of on‐demand treatment and what treatments should be used? (3) What are the goals of treatment? (4) Should HAE management be different for special HAE patient groups such as children or pregnant/breast‐feeding women? and (5) How should HAE patients monitor their disease activity, impact, and control? It is also the intention of this guideline to help establish global standards for the management of HAE and to encourage and facilitate the use of recommended diagnostics and therapies for all patients. |
| Author | Kaplan, Allen Phillip Magerl, Markus Castaldo, Anthony Gompels, Mark Boysen, Henrik Balle Hide, Michihiro Craig, Timothy Busse, Paula J. Boccon‐Gibod, Isabelle Bygum, Anette Guidos‐Fogelbach, Guillermo Farkas, Henriette Kiani‐Alikhan, Sorena Prior, Nieves Varga, Lilian Agnes Toubi, Elias Spaeth, Peter J. Stobiecki, Marcin Lockey, Richard Rafique Sheikh, Farrukh Bara, Noémi‐Anna Caballero, Teresa Aberer, Werner Martinez Saguer, Inmaculada Grumach, Anete S. Betschel, Stephen Matta, Juan José Maurer, Marcus Riedl, Marc Weller, Karsten Kang, Hye‐Ryun Smith, William B. Pawankar, Ruby Katelaris, Constance Gower, Richard Bork, Konrad Ritchie, Bruce Cohn, Danny M. Reshef, Avner Aygören‐Pürsün, Emel Csuka, Dorottya Longhurst, Hilary Nast, Alexander Peter, Jonathan Zanichelli, Andrea Nieto‐Martinez, Sandra A. Brodszki, Nicholas Lumry, William R. Zuraw, Bruce Porebski, Grzegorz Ansotegui, Ignacio J. Lei, Wei‐Te Nguyen, Dinh Cancian, Mauro Malbran, Alejandro Banerji, Aleena Bouillet, Laurence MacGinnitie, Andrew Zhi, Yuxiang |
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surname: Gompels fullname: Gompels, Mark organization: North Bristol NHS Trust – sequence: 23 givenname: Richard surname: Gower fullname: Gower, Richard organization: Principle Research Solutions – sequence: 24 givenname: Anete S. surname: Grumach fullname: Grumach, Anete S. organization: Centro Universitario FMABC – sequence: 25 givenname: Guillermo surname: Guidos‐Fogelbach fullname: Guidos‐Fogelbach, Guillermo organization: Instituto Politécnico Nacional SEPI‐ENMH – sequence: 26 givenname: Michihiro surname: Hide fullname: Hide, Michihiro organization: Hiroshima University – sequence: 27 givenname: Hye‐Ryun orcidid: 0000-0002-2317-4201 surname: Kang fullname: Kang, Hye‐Ryun organization: Seoul National University College of Medicine – sequence: 28 givenname: Allen Phillip orcidid: 0000-0002-6566-4743 surname: Kaplan fullname: Kaplan, Allen Phillip organization: Medical university of South Carolina – sequence: 29 givenname: Constance surname: Katelaris fullname: Katelaris, Constance organization: Campbelltown Hospital and Western Sydney University – sequence: 30 givenname: Sorena surname: Kiani‐Alikhan fullname: Kiani‐Alikhan, Sorena organization: Barts Health NHS Trust – sequence: 31 givenname: Wei‐Te orcidid: 0000-0003-1677-8901 surname: Lei fullname: Lei, Wei‐Te organization: Mackay Memorial Hospital – sequence: 32 givenname: Richard surname: Lockey fullname: Lockey, Richard organization: University of South Florida – sequence: 33 givenname: Hilary surname: Longhurst fullname: Longhurst, Hilary organization: University of Auckland – sequence: 34 givenname: William R. surname: Lumry fullname: Lumry, William R. organization: University of Texas Health Science Center – sequence: 35 givenname: Andrew orcidid: 0000-0002-9451-3733 surname: MacGinnitie fullname: MacGinnitie, Andrew organization: Harvard Medical School – sequence: 36 givenname: Alejandro surname: Malbran fullname: Malbran, Alejandro organization: Unidad de Alergia, Asma e Inmunología Clínica – 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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35006617$$D View this record in MEDLINE/PubMed https://hal.science/hal-04997520$$DView record in HAL |
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| ContentType | Journal Article |
| Copyright | 2022 The Authors. published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. 2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License |
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| Issue | 7 |
| Keywords | C1 inhibitor disease control hereditary angioedema management guideline DELPHI |
| Language | English |
| License | Attribution-NonCommercial-NoDerivs 2022 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0 |
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| Notes | Funding information LEN/HAEi network of Angioedema Centers of Reference and Excellence (ACARE 2 Funding and support of the development of this update and revision of the guideline came from WAO and EAACI. This revision and update of the guideline benefitted from the help and support of the GA Important As this is an international guideline, no information is provided regarding the licensing of the drugs mentioned for the treatment of HAE. It is in the duty of the treating physician to adhere to the relevant local regulations. ) Marcus Maurer, Markus Magerl, Stephen Betschel and Timothy Craig contributed equally. https://acare‐network.com ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Instructional Material/Guideline-3 content type line 23 |
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| PublicationDate | July 2022 |
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| PublicationPlace | Denmark |
| PublicationPlace_xml | – name: Denmark – name: Zurich |
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| SubjectTerms | Angioedema Angioedemas, Hereditary - prevention & control Angioedemas, Hereditary - therapy Breast C1 inhibitor Child Clinical decision making Complement C1 Inhibitor Protein - genetics Complement C1 Inhibitor Protein - therapeutic use Complement component C1 Consensus DELPHI Diagnosis disease control Edema Female Genetic disorders guideline hereditary angioedema Humans Inflammatory diseases Life Sciences Management Medical treatment Patients Pregnancy Skin |
| Title | The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update |
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