What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies

Summary Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE‐associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being...

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Vydáno v:British journal of haematology Ročník 180; číslo 3; s. 335 - 345
Hlavní autoři: Trégouët, David‐Alexandre, Morange, Pierre‐Emmanuel
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.02.2018
Wiley
Témata:
Cardiology and cardiovascular system
Genetic diversity
Genetics
Hematology
Human genetics
Human health and pathology
Life Sciences
next generation sequencing
sequencing technologies
Thromboembolism
venous thromboembolism
genetics
sequencing technologies
next generation sequencing
venous thromboembolism
ISSN:0007-1048, 1365-2141, 1365-2141
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Shrnutí:Summary Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE‐associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being claimed as VTE associated genes. Finally, several research strategies are briefly described to identify other molecular determinants of the disease.
Bibliografie:ObjectType-Article-1
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ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.15004