Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma

A major problem in head and neck cancer surgery is the high rate of local relapse (LR). In at least 25% of the surgically treated head and neck squamous cell carcinoma (HNSCC) patients, a genetically defined preneoplastic lesion, also known as “field,” can be detected in the surgical margins. A rema...

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Bibliographic Details
Published in:	International journal of cancer Vol. 128; no. 8; pp. 1852 - 1859
Main Authors:	Graveland, A. Peggy, Golusinski, Pawel J., Buijze, Marijke, Douma, Rinze, Sons, Nanet, Kuik, Dirk J., Bloemena, Elisabeth, Leemans, C. René, Brakenhoff, Ruud H., Braakhuis, Boudewijn J.M.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.04.2011 Wiley-Blackwell
Subjects:	Biological and medical sciences cancer progression Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery chromosome 3 Chromosomes, Human, Pair 17 - genetics Chromosomes, Human, Pair 3 - genetics Chromosomes, Human, Pair 9 - genetics Data processing DNA, Neoplasm - genetics Dysplasia Female Head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery Humans Immunoenzyme Techniques local relapse LOH Loss of Heterozygosity Lymphatic Metastasis Male Medical sciences Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - surgery Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology p53 p53 protein Polymerase Chain Reaction preneoplastic field Prognosis Risk factors squamous cell carcinoma Surgery Transformation Tumor Suppressor Protein p53 - metabolism Tumors Genetic mapping Relapse Allelic imbalance Premalignant lesion LOH Malignant tumor preneoplastic field Chromosome C9 p53 Cancerology TP53 Gene Treatment local relapse cancer progression Surgery Loss of heterozygosity Tumor progression ENT disease Head and neck cancer Head and neck squamous cell carcinoma Surgical margin Predictive factor Cancer Tumor suppressor gene
ISSN:	0020-7136, 1097-0215, 1097-0215
Online Access:	Get full text
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