The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma

Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor polluta...

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Bibliographic Details
Published in:Allergy (Copenhagen) Vol. 79; no. 7; pp. 1761 - 1788
Main Authors: Agache, Ioana, Canelo‐Aybar, Carlos, Annesi‐Maesano, Isabella, Cecchi, Lorenzo, Biagioni, Benedetta, Chung, Fan, D'Amato, Gennaro, Damialis, Athanasios, Del Giacco, Stefano, De las Vecillas, Leticia, Dominguez‐Ortega, Javier, Galàn, Carmen, Gilles, Stefanie, Giovannini, Mattia, Holgate, Stephen, Jeebhay, Mohamed, Nadeau, Kari, Papadopoulos, Nikolaos, Quirce, Santiago, Sastre, Joaquin, Traidl‐Hoffmann, Claudia, Walusiak‐Skorupa, Jolanta, Sousa‐Pinto, Bernardo, Salazar, Josefina, Rodríguez‐Tanta, L. Yesenia, Cantero, Yahveth, Montesinos‐Guevara, Camila, Song, Yang, Alvarado‐Gamarra, Giancarlo, Sola, Ivan, Alonso‐Coello, Pablo, Nieto‐Gutierrez, Wendy, Jutel, Marek, Akdis, Cezmi A.
Format: Journal Article
Language:English
Published: Denmark Blackwell Publishing Ltd 01.07.2024
Wiley
Subjects:
Air Pollution, Indoor - adverse effects
Allergic diseases
Asthma
Asthma - epidemiology
Asthma - etiology
Environmental Exposure - adverse effects
Environmental Sciences
GRADE
guideline
Human health and pathology
Humans
Hypersensitivity - epidemiology
Hypersensitivity - etiology
Incidence
indoor pollution
Life Sciences
Mold
Pesticides
Pesticides - adverse effects
Pollutants
Systematic review
VOCs
Volatile organic compounds
Volatile Organic Compounds - adverse effects
GRADE
asthma
indoor pollution
systematic review
guideline
ISSN:0105-4538, 1398-9995, 1398-9995
Online Access:Get full text
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Summary:Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new‐onset asthma and critical and important asthma‐related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact). Exposure to damp/mould increases the risk of new‐onset wheeze (moderate certainty evidence). Exposure to cleaning agents may be associated with a higher risk of new‐onset asthma and with asthma severity (low level of certainty). Exposure to pesticides and VOCs may increase the risk of new‐onset asthma (very low certainty evidence). The impact on asthma‐related outcomes of all major indoor pollutants is uncertain. As the level of certainty is low or very low for most of the available evidence on the impact of indoor pollutants on asthma‐related outcomes more rigorous research in the field is warranted.
Bibliography:Ioana Agache and Carlos Canelo‐Aybar: Co‐first equal contribution.
Wendy Nieto‐Gutierrez, Marek Jutel and Cezmi A. Akdis: Co‐last equal contribution.
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ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.16051