ATF5-Mediated Mitochondrial Unfolded Protein Response (UPR mt ) Protects Neurons Against Oxygen-Glucose Deprivation and Cerebral Ischemia

The mitochondrial unfolded protein response (UPR ) is an evolutionarily conserved mitochondrial response that is critical for maintaining mitochondrial and energetic homeostasis under cellular stress after tissue injury and disease. Here, we ask whether UPR may be a potential therapeutic target for...

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Vydané v:	Stroke (1970) Ročník 55; číslo 7; s. 1904
Hlavní autori:	An, Hong, Zhou, Bing, Hayakawa, Kazuhide, Durán Laforet, Violeta, Park, Ji-Hyun, Nakamura, Yoshihiko, Mandeville, Emiri T, Liu, Ning, Guo, Shuzhen, Yu, Zhanyang, Shi, Jingfei, Wu, Di, Li, Wenlu, Lo, Eng H, Ji, Xunming
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.07.2024
Predmet:	Animals Brain Ischemia - metabolism Cells, Cultured Glucose - deficiency Infarction, Middle Cerebral Artery - metabolism Male Mice Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Oxygen - metabolism Unfolded Protein Response - drug effects meclizine oligomycins homeostasis unfolded protein response ischemic stroke
ISSN:	1524-4628, 1524-4628
On-line prístup:	Zistit podrobnosti o prístupe
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