Multiple causal variants underlie genetic associations in humans

Associations between genetic variation and traits are often in noncoding regions with strong linkage disequilibrium (LD), where a single causal variant is assumed to underlie the association. We applied a massively parallel reporter assay (MPRA) to functionally evaluate genetic variants in high, loc...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 375; no. 6586; p. 1247
Main Authors:	Abell, Nathan S, DeGorter, Marianne K, Gloudemans, Michael J, Greenwald, Emily, Smith, Kevin S, He, Zihuai, Montgomery, Stephen B
Format:	Journal Article
Language:	English
Published:	United States 18.03.2022
Subjects:	Alleles Asthma - genetics Chromatin - metabolism Genetic Predisposition to Disease Genetic Variation Genome, Human Genome-Wide Association Study Haplotypes Histone Code Humans Inflammatory Bowel Diseases - genetics Linkage Disequilibrium Multifactorial Inheritance Multiple Sclerosis - genetics Phenotype Platelet Count Quantitative Trait Loci Transcription Factors - genetics Transcription Factors - metabolism Untranslated Regions
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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