The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure

Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (ANP) and brain natriuretic peptides (BNP). Under n...

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Vydáno v:Journal of clinical medicine Ročník 8; číslo 10; s. 1746
Hlavní autoři: Lugnier, Claire, Meyer, Alain, Charloux, Anne, Andrès, Emmanuel, Gény, Bernard, Talha, Samy
Médium: Journal Article
Jazyk:angličtina
Vydáno: MDPI 21.10.2019
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ISSN:2077-0383, 2077-0383
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Abstract Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (ANP) and brain natriuretic peptides (BNP). Under normal conditions, these peptides are synthesized in response to atrial cardiomyocyte stretch, increase natriuresis, diuresis, and vascular permeability through binding of the second intracellular messenger’s guanosine 3′,5′-cyclic monophosphate (cGMP) to specific receptors. During heart failure (HF), the beneficial effects of the enhanced cardiac hormones secretion are reduced, in connection with renal resistance to NP. In addition, there is a BNP paradox characterized by a physiological inefficiency of the BNP forms assayed by current methods. In this context, it appears interesting to improve the efficiency of the cardiac natriuretic system by inhibiting cyclic nucleotide phosphodiesterases, responsible for the degradation of cGMP. Recent data support such a therapeutic approach which can improve the quality of life and the prognosis of patients with HF.
AbstractList Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (ANP) and brain natriuretic peptides (BNP). Under normal conditions, these peptides are synthesized in response to atrial cardiomyocyte stretch, increase natriuresis, diuresis, and vascular permeability through binding of the second intracellular messenger’s guanosine 3′,5′-cyclic monophosphate (cGMP) to specific receptors. During heart failure (HF), the beneficial effects of the enhanced cardiac hormones secretion are reduced, in connection with renal resistance to NP. In addition, there is a BNP paradox characterized by a physiological inefficiency of the BNP forms assayed by current methods. In this context, it appears interesting to improve the efficiency of the cardiac natriuretic system by inhibiting cyclic nucleotide phosphodiesterases, responsible for the degradation of cGMP. Recent data support such a therapeutic approach which can improve the quality of life and the prognosis of patients with HF.
Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (ANP) and brain natriuretic peptides (BNP). Under normal conditions, these peptides are synthesized in response to atrial cardiomyocyte stretch, increase natriuresis, diuresis, and vascular permeability through binding of the second intracellular messenger's guanosine 3',5'-cyclic monophosphate (cGMP) to specific receptors. During heart failure (HF), the beneficial effects of the enhanced cardiac hormones secretion are reduced, in connection with renal resistance to NP. In addition, there is a BNP paradox characterized by a physiological inefficiency of the BNP forms assayed by current methods. In this context, it appears interesting to improve the efficiency of the cardiac natriuretic system by inhibiting cyclic nucleotide phosphodiesterases, responsible for the degradation of cGMP. Recent data support such a therapeutic approach which can improve the quality of life and the prognosis of patients with HF.Besides pumping, the heart participates in hydro-sodium homeostasis and systemic blood pressure regulation through its endocrine function mainly represented by the large family of natriuretic peptides (NPs), including essentially atrial natriuretic (ANP) and brain natriuretic peptides (BNP). Under normal conditions, these peptides are synthesized in response to atrial cardiomyocyte stretch, increase natriuresis, diuresis, and vascular permeability through binding of the second intracellular messenger's guanosine 3',5'-cyclic monophosphate (cGMP) to specific receptors. During heart failure (HF), the beneficial effects of the enhanced cardiac hormones secretion are reduced, in connection with renal resistance to NP. In addition, there is a BNP paradox characterized by a physiological inefficiency of the BNP forms assayed by current methods. In this context, it appears interesting to improve the efficiency of the cardiac natriuretic system by inhibiting cyclic nucleotide phosphodiesterases, responsible for the degradation of cGMP. Recent data support such a therapeutic approach which can improve the quality of life and the prognosis of patients with HF.
Author Meyer, Alain
Lugnier, Claire
Andrès, Emmanuel
Gény, Bernard
Talha, Samy
Charloux, Anne
AuthorAffiliation 2 Department of Physiology and Functional Explorations, New Civil Hospital, University Hospitals of Strasbourg, 1 Place de l’Hôpital, CEDEX 67091 Strasbourg, France
1 Institute of Physiology, FMTS-EA 3072, Faculty of Medicine, University of Strasbourg, 11 Humann Street, 67000 Strasbourg, France; claire.lugnier@unistra.fr (C.L.); alain.meyer1@chru-strasbourg.fr (A.M.); anne.charloux@chru-strasbourg.fr (A.C.); emmanuel.andres@chru-strasbourg.fr (E.A.); bernard.geny@chru-strasbourg.fr (B.G.)
3 Department of Internal Medicine and Metabolic Diseases, Medical Clinic B, Civil Hospital, University Hospitals of Strasbourg, 1 Place de l’Hôpital, CEDEX 67091 Strasbourg, France
AuthorAffiliation_xml – name: 2 Department of Physiology and Functional Explorations, New Civil Hospital, University Hospitals of Strasbourg, 1 Place de l’Hôpital, CEDEX 67091 Strasbourg, France
– name: 1 Institute of Physiology, FMTS-EA 3072, Faculty of Medicine, University of Strasbourg, 11 Humann Street, 67000 Strasbourg, France; claire.lugnier@unistra.fr (C.L.); alain.meyer1@chru-strasbourg.fr (A.M.); anne.charloux@chru-strasbourg.fr (A.C.); emmanuel.andres@chru-strasbourg.fr (E.A.); bernard.geny@chru-strasbourg.fr (B.G.)
– name: 3 Department of Internal Medicine and Metabolic Diseases, Medical Clinic B, Civil Hospital, University Hospitals of Strasbourg, 1 Place de l’Hôpital, CEDEX 67091 Strasbourg, France
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Cites_doi 10.1038/ki.1996.257
10.1371/journal.pone.0014227
10.1152/ajpregu.00324.2010
10.2741/1687
10.1152/japplphysiol.00239.2012
10.1161/hc4401.098432
10.1007/s00018-017-2723-6
10.1152/ajprenal.00164.2014
10.2310/JIM.0b013e3181948b37
10.1016/j.pharmthera.2014.04.007
10.1093/cvr/cvq331
10.1161/CIRCHEARTFAILURE.114.001174
10.1161/CIRCRESAHA.107.153585
10.1161/CIRCRESAHA.109.197947
10.3390/ijms20092281
10.1038/nrd4228
10.1161/CIRCHEARTFAILURE.108.790774
10.1186/s13036-017-0093-0
10.1016/0006-2952(90)90650-A
10.1097/00001756-200102120-00003
10.1042/BJ20070629
10.1161/01.RES.62.2.191
10.1016/0167-0115(88)90422-3
10.1152/ajpheart.00902.2002
10.1016/B978-0-12-407680-8.00001-4
10.1111/j.1476-5381.2011.01729.x
10.1074/jbc.M110.173252
10.1373/clinchem.2005.057638
10.1161/hh0202.104108
10.1210/er.2005-0014
10.1111/apha.12767
10.1016/j.peptides.2010.04.001
10.1016/0895-7061(94)00210-3
10.1161/HYPERTENSIONAHA.106.081083
10.15252/emmm.201707604
10.1016/j.yjmcc.2004.01.001
10.1161/CIRCRESAHA.114.305892
10.1271/bbb.67.973
10.1042/CS20150469
10.1172/JCI7362
10.1373/clinchem.2004.032490
10.1016/j.pbiomolbio.2015.12.001
10.1161/CIRCHEARTFAILURE.110.944694
10.1016/j.yjmcc.2010.03.016
10.1093/ajh/4.11.909
10.1007/164_2016_82
10.1038/nm.3128
10.1021/jm00375a001
10.1161/CIRCULATIONAHA.106.655266
10.1038/332078a0
10.1161/CIRCRESAHA.109.198515
10.1097/01.HDX.0000074517.30102.64
10.1378/chest.129.2.417
10.1016/0006-291X(83)91091-4
10.1373/clinchem.2008.113373
10.3389/fphys.2018.00692
10.1042/bj20021087
10.1111/ctr.12969
10.1097/00005344-198908000-00005
10.1073/pnas.070371497
10.1093/ajh/hpx026
10.1152/ajprenal.00418.2006
10.1210/er.2013-1053
10.2174/187152509787047667
10.1073/pnas.0508782102
10.1253/circj.CJ-15-0589
10.1530/EC-14-0012
10.1016/S0041-1345(98)00083-9
10.1016/0006-291X(91)90471-I
10.1111/j.1749-6632.1988.tb33348.x
10.1016/j.jacc.2013.05.057
10.1161/CIRCHEARTFAILURE.109.903849
10.1016/j.healun.2009.05.038
10.1373/clinchem.2016.269712
10.1016/j.jacc.2012.01.060
10.1002/ejhf.656
10.1016/1071-9164(94)90010-8
10.1016/j.regpep.2011.05.005
10.1152/jappl.1998.85.6.2270
10.1161/01.CIR.98.25.2849
10.1016/j.tem.2005.10.007
10.1373/clinchem.2010.143883
10.1093/eurjhf/hfr146
10.1111/odi.12275
10.1038/ki.1996.491
10.1016/S0021-9258(19)50052-7
10.1007/s00210-016-1289-4
10.1248/bpb.32.1545
10.1242/dev.100370
10.1016/S0008-6363(95)00121-2
10.1161/01.RES.63.1.207
10.1007/BF00877818
10.1152/jappl.2001.91.3.1421
10.1016/j.sxmr.2017.08.001
10.1161/01.RES.0000152262.22968.72
10.1007/s00392-005-0246-x
10.1046/j.1365-2362.2003.01222.x
10.1111/j.1476-5381.1991.tb12457.x
10.1007/s11886-000-0069-3
10.1096/fasebj.14.10.1345
10.1161/JAHA.117.006513
10.4330/wjc.v6.i1.4
10.1097/00005344-199011000-00016
10.1074/jbc.274.21.14926
10.1042/CS20100305
10.3390/jcm8070924
10.1373/clinchem.2016.265140
10.1248/bpb.30.1084
10.1152/ajpregu.1991.261.4.R858
10.1074/jbc.271.16.9863
10.1161/CIRCHEARTFAILURE.112.000057
10.1016/0024-3205(81)90370-2
10.1016/0006-2952(86)90333-3
10.1161/01.CIR.100.24.2443
10.1007/s00109-010-0641-2
10.1038/nature14332
10.1373/clinchem.2006.076141
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References Chen (ref_82) 1999; 100
Ahmad (ref_25) 2015; 21
Talha (ref_57) 2013; 114
Ichiki (ref_93) 2013; 61
Gaggin (ref_109) 2019; 21
Keravis (ref_19) 2012; 165
Matsukawa (ref_46) 2011; 300
Schwachtgen (ref_50) 2005; 94
Chun (ref_75) 2003; 370
Heublein (ref_88) 2007; 49
Cruickshank (ref_114) 1993; 7
(ref_66) 1991; 18
Sadoshima (ref_64) 1992; 267
Stoclet (ref_28) 1988; 522
Gomez (ref_107) 2012; 14
Lugnier (ref_32) 1983; 113
Charloux (ref_86) 2003; 33
Yan (ref_90) 1999; 274
Patrucco (ref_38) 2010; 49
Itoh (ref_47) 1991; 176
Muller (ref_115) 1990; 16
Richter (ref_116) 2009; 105
Tarjan (ref_45) 1988; 23
Schlueter (ref_58) 2014; 144
Kim (ref_124) 2001; 104
Seferian (ref_101) 2007; 53
Gupta (ref_17) 2015; 79
Yellon (ref_52) 2003; 284
Nagendran (ref_119) 2007; 116
Semenov (ref_102) 2009; 55
Ma (ref_71) 2004; 36
Chen (ref_43) 2000; 2
Fu (ref_11) 2018; 12
Klinger (ref_37) 2006; 129
Rybalkin (ref_125) 2002; 90
Bae (ref_42) 2011; 10
Sudoh (ref_6) 1988; 332
Potter (ref_14) 2006; 27
Yanaka (ref_120) 2003; 67
Huntley (ref_92) 2015; 8
Bryan (ref_85) 2007; 292
Lincoln (ref_20) 2001; 91
Lee (ref_39) 2015; 519
Salles (ref_106) 2013; 6
Abassi (ref_81) 1991; 261
Maack (ref_41) 1996; 49
Stockmann (ref_77) 1988; 63
Talha (ref_73) 2011; 89
Moghtadaei (ref_112) 2016; 120
Volpe (ref_95) 2016; 130
Geny (ref_69) 1998; 85
Stoupakis (ref_13) 2003; 5
Durocher (ref_10) 1998; 53
Magga (ref_97) 2004; 50
Azevedo (ref_23) 2014; 35
Mastromarino (ref_62) 2011; 120
Liang (ref_63) 1999; 104
Yokota (ref_67) 1995; 8
Molina (ref_118) 2012; 59
Suzuki (ref_98) 2017; 63
Lugnier (ref_29) 1990; 39
Chiba (ref_3) 2018; 75
Vesely (ref_72) 2009; 57
Fu (ref_105) 2018; 9
Lewis (ref_89) 2017; 63
Fiscus (ref_53) 2001; 12
Miller (ref_126) 2009; 105
Cohen (ref_15) 1996; 27
Zoccarato (ref_122) 2015; 117
Komas (ref_30) 1991; 104
Weidemann (ref_76) 2008; 409
Wang (ref_55) 2007; 30
Bruneau (ref_18) 1996; 31
Wang (ref_110) 2017; 8
Supaporn (ref_84) 1996; 50
Margulies (ref_83) 1994; 1
Berlan (ref_59) 2000; 14
Anttila (ref_79) 2017; 220
Edwards (ref_12) 1988; 62
Ghazi (ref_36) 2011; 4
Magri (ref_61) 1988; 98
Theilig (ref_40) 2015; 308
Borenstein (ref_5) 1981; 28
Brandt (ref_94) 2006; 52
Semenov (ref_91) 2010; 56
Lugnier (ref_27) 1986; 35
Gramley (ref_74) 2009; 28
Ogawa (ref_65) 2014; 3
Incerpi (ref_56) 2010; 31
ref_117
Boolell (ref_33) 1996; 8
McGrath (ref_44) 2005; 16
ref_111
Kim (ref_113) 2017; 243
Komas (ref_26) 1989; 14
Yafi (ref_34) 2018; 6
Niederkofler (ref_99) 2008; 1
Hawkridge (ref_100) 2005; 102
Rubattu (ref_22) 2010; 88
Dong (ref_104) 2010; 3
Bristol (ref_31) 1984; 27
Pankow (ref_96) 2007; 101
Vaandrager (ref_21) 2005; 10
Tamura (ref_48) 2000; 97
Takimoto (ref_35) 2005; 96
Arjamaa (ref_78) 2014; 6
Talha (ref_2) 2015; 10
Das (ref_49) 2009; 7
MacLellan (ref_70) 1998; 30
Goharian (ref_60) 2017; 30
ref_108
Wagner (ref_123) 2016; 389
Sun (ref_54) 2009; 32
Nakamura (ref_9) 1991; 4
ref_1
Maurice (ref_24) 2014; 13
Mehel (ref_121) 2013; 62
(ref_87) 2017; 19
Becker (ref_51) 2014; 141
ref_4
Kim (ref_80) 2013; 19
Leduc (ref_103) 1993; 15
ref_7
Meyer (ref_8) 1998; 21
Ralat (ref_16) 2011; 286
Gulati (ref_68) 2017; 11
References_xml – volume: 49
  start-page: 1732
  year: 1996
  ident: ref_41
  article-title: Role of atrial natriuretic factor in volume control
  publication-title: Kidney Int.
  doi: 10.1038/ki.1996.257
– ident: ref_117
  doi: 10.1371/journal.pone.0014227
– volume: 300
  start-page: R624
  year: 2011
  ident: ref_46
  article-title: Angiotensin II-stimulated secretion of arginine vasopressin is inhibited by atrial natriuretic peptide in humans
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.00324.2010
– volume: 10
  start-page: 2150
  year: 2005
  ident: ref_21
  article-title: Molecular properties and biological functions of cGMP-dependent protein kinase II
  publication-title: Front. Biosci.
  doi: 10.2741/1687
– volume: 114
  start-page: 172
  year: 2013
  ident: ref_57
  article-title: Pretreatment with brain natriuretic peptide reduces skeletal muscle mitochondrial dysfunction and oxidative stress after ischemia-reperfusion
  publication-title: J. Appl. Physiol.
  doi: 10.1152/japplphysiol.00239.2012
– volume: 104
  start-page: 2338
  year: 2001
  ident: ref_124
  article-title: Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance
  publication-title: Circulation
  doi: 10.1161/hc4401.098432
– volume: 75
  start-page: 1349
  year: 2018
  ident: ref_3
  article-title: Cardiomyokines from the heart
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-017-2723-6
– volume: 308
  start-page: F1047
  year: 2015
  ident: ref_40
  article-title: ANP-induced signaling cascade and its implications in renal pathophysiology
  publication-title: Am. J. Physiol. Renal. Physiol.
  doi: 10.1152/ajprenal.00164.2014
– volume: 57
  start-page: 29
  year: 2009
  ident: ref_72
  article-title: Cardiac natriuretic peptides gene expression and secretion in inflammation
  publication-title: J. Investig. Med.
  doi: 10.2310/JIM.0b013e3181948b37
– volume: 144
  start-page: 12
  year: 2014
  ident: ref_58
  article-title: Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2014.04.007
– ident: ref_1
– volume: 89
  start-page: 273
  year: 2011
  ident: ref_73
  article-title: Mechanisms involved in increased plasma brain natriuretic peptide after heart transplantation
  publication-title: Cardiovasc. Res.
  doi: 10.1093/cvr/cvq331
– volume: 8
  start-page: 89
  year: 2015
  ident: ref_92
  article-title: Pro-B-type natriuretic peptide-1-108 processing and degradation in human heart failure
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.114.001174
– volume: 101
  start-page: 875
  year: 2007
  ident: ref_96
  article-title: Successive action of meprin A and neprilysin catabolizes B-type natriuretic peptide
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.107.153585
– volume: 105
  start-page: 784
  year: 2009
  ident: ref_116
  article-title: Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.197947
– ident: ref_7
  doi: 10.3390/ijms20092281
– ident: ref_4
– volume: 13
  start-page: 290
  year: 2014
  ident: ref_24
  article-title: Advances in targeting cyclic nucleotide phosphodiesterases
  publication-title: Nat. Rev. Drug. Discov.
  doi: 10.1038/nrd4228
– volume: 1
  start-page: 258
  year: 2008
  ident: ref_99
  article-title: Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.108.790774
– volume: 12
  start-page: 2
  year: 2018
  ident: ref_11
  article-title: Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure
  publication-title: J. Biol. Eng.
  doi: 10.1186/s13036-017-0093-0
– volume: 39
  start-page: 75
  year: 1990
  ident: ref_29
  article-title: Characterization of cyclic nucleotide from cultured bovine aortic endothelial cells
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(90)90650-A
– volume: 12
  start-page: 185
  year: 2001
  ident: ref_53
  article-title: Natriuretic peptides inhibit apoptosis and prolong the survival of serum-deprived PC12 cells
  publication-title: Neuroreport
  doi: 10.1097/00001756-200102120-00003
– volume: 409
  start-page: 233
  year: 2008
  ident: ref_76
  article-title: Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction
  publication-title: Biochem. J.
  doi: 10.1042/BJ20070629
– volume: 62
  start-page: 191
  year: 1988
  ident: ref_12
  article-title: Atrial stretch, not pressure, is the principal determinant controlling the acute release of atrial natriuretic factor
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.62.2.191
– volume: 23
  start-page: 63
  year: 1988
  ident: ref_45
  article-title: Atrial natriuretic peptide inhibits water and sodium intake in rabbits
  publication-title: Regul. Pept.
  doi: 10.1016/0167-0115(88)90422-3
– volume: 284
  start-page: H1592
  year: 2003
  ident: ref_52
  article-title: B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00902.2002
– volume: 61
  start-page: 1
  year: 2013
  ident: ref_93
  article-title: BNP molecular forms and processing by the cardiac serine protease corin
  publication-title: Adv. Clin. Chem.
  doi: 10.1016/B978-0-12-407680-8.00001-4
– volume: 165
  start-page: 1288
  year: 2012
  ident: ref_19
  article-title: Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: Benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.2011.01729.x
– volume: 286
  start-page: 4670
  year: 2011
  ident: ref_16
  article-title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.173252
– volume: 52
  start-page: 82
  year: 2006
  ident: ref_94
  article-title: Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2005.057638
– volume: 90
  start-page: 151
  year: 2002
  ident: ref_125
  article-title: Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation
  publication-title: Circ. Res.
  doi: 10.1161/hh0202.104108
– volume: 27
  start-page: 47
  year: 2006
  ident: ref_14
  article-title: Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2005-0014
– volume: 220
  start-page: 28
  year: 2017
  ident: ref_79
  article-title: Hypoxia exposure and B-type natriuretic peptide release from Langendorff heart of rats
  publication-title: Acta Physiol. (Oxf.)
  doi: 10.1111/apha.12767
– volume: 31
  start-page: 1412
  year: 2010
  ident: ref_56
  article-title: Atrial natriuretic peptide and oxidative stress
  publication-title: Peptides
  doi: 10.1016/j.peptides.2010.04.001
– volume: 8
  start-page: 301
  year: 1995
  ident: ref_67
  article-title: Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats
  publication-title: Am. J. Hypertens.
  doi: 10.1016/0895-7061(94)00210-3
– volume: 49
  start-page: 1114
  year: 2007
  ident: ref_88
  article-title: Immunoreactivity and guanosine 3′,5′-cyclic monophosphate activating actions of various molecular forms of human B-type natriuretic peptide
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.106.081083
– volume: 8
  start-page: 1150
  year: 2017
  ident: ref_110
  article-title: GDF15 is a heart-derived hormone that regulates body growth
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201707604
– volume: 36
  start-page: 505
  year: 2004
  ident: ref_71
  article-title: Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2004.01.001
– volume: 117
  start-page: 707
  year: 2015
  ident: ref_122
  article-title: Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.114.305892
– volume: 67
  start-page: 973
  year: 2003
  ident: ref_120
  article-title: cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles
  publication-title: Biosci. Biochem.
  doi: 10.1271/bbb.67.973
– volume: 130
  start-page: 57
  year: 2016
  ident: ref_95
  article-title: The natriuretic peptides system in the pathophysiology of heart failure: From molecular basis to treatment
  publication-title: Clin. Sci. (Lond.)
  doi: 10.1042/CS20150469
– volume: 104
  start-page: 1603
  year: 1999
  ident: ref_63
  article-title: Mechanical strain activates BNP gene transcription through a p38/NF-κB—dependent mechanism
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI7362
– volume: 50
  start-page: 1576
  year: 2004
  ident: ref_97
  article-title: Molecular heterogeneity has a major impact on the measurement of circulating N-terminal fragments of A- and B-type natriuretic peptides
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2004.032490
– volume: 120
  start-page: 37e49
  year: 2016
  ident: ref_112
  article-title: Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes
  publication-title: Prog. Biophys. Mol. Biol.
  doi: 10.1016/j.pbiomolbio.2015.12.001
– volume: 4
  start-page: 8
  year: 2011
  ident: ref_36
  article-title: PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: Results of a 1-year, prospective, randomized, placebo-controlled study
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.110.944694
– volume: 49
  start-page: 330
  year: 2010
  ident: ref_38
  article-title: Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes
  publication-title: J. Mol. Cell. Cardiol.
  doi: 10.1016/j.yjmcc.2010.03.016
– volume: 4
  start-page: 909
  year: 1991
  ident: ref_9
  article-title: Atrial natriuretic peptide and brain natriuretic peptide coexist in the secretory granules of human cardiac myocytes
  publication-title: Am. J. Hypertens.
  doi: 10.1093/ajh/4.11.909
– volume: 243
  start-page: 249
  year: 2017
  ident: ref_113
  article-title: Cardiac phosphodiesterases and their modulation for treating heart disease
  publication-title: Handb. Exp. Pharmacol.
  doi: 10.1007/164_2016_82
– volume: 21
  start-page: 103
  year: 1998
  ident: ref_8
  article-title: Urodilatin, a natriuretic peptide with clinical implications
  publication-title: Eur. J. Med. Res.
– volume: 19
  start-page: 567
  year: 2013
  ident: ref_80
  article-title: GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
  publication-title: Nat. Med.
  doi: 10.1038/nm.3128
– volume: 27
  start-page: 1099
  year: 1984
  ident: ref_31
  article-title: Cardiotonic agents: 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: Novel positive inotropic agents for the treatment of congestive heart failure
  publication-title: J. Med. Chem.
  doi: 10.1021/jm00375a001
– volume: 116
  start-page: 238
  year: 2007
  ident: ref_119
  article-title: Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.655266
– volume: 332
  start-page: 78
  year: 1988
  ident: ref_6
  article-title: A new natriuretic peptide in porcine brain
  publication-title: Nature
  doi: 10.1038/332078a0
– volume: 105
  start-page: 956
  year: 2009
  ident: ref_126
  article-title: Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.109.198515
– volume: 5
  start-page: 215
  year: 2003
  ident: ref_13
  article-title: Natriuretic peptides: Biochemistry, physiology, and therapeutic role in heart failure
  publication-title: Heart Dis.
  doi: 10.1097/01.HDX.0000074517.30102.64
– volume: 129
  start-page: 417
  year: 2006
  ident: ref_37
  article-title: Pulmonary hemodynamic responses to brain natriuretic peptide and sildenafil in patients with pulmonary arterial hypertension
  publication-title: Chest
  doi: 10.1378/chest.129.2.417
– volume: 113
  start-page: 954
  year: 1983
  ident: ref_32
  article-title: Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/0006-291X(83)91091-4
– volume: 55
  start-page: 489
  year: 2009
  ident: ref_102
  article-title: Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2008.113373
– volume: 9
  start-page: 692
  year: 2018
  ident: ref_105
  article-title: Brain natriuretic peptide and its biochemical, analytical, and clinical issues in heart failure: A narrative review
  publication-title: Front. Phys.
  doi: 10.3389/fphys.2018.00692
– volume: 370
  start-page: 149
  year: 2003
  ident: ref_75
  article-title: Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1
  publication-title: Biochem. J.
  doi: 10.1042/bj20021087
– ident: ref_108
  doi: 10.1111/ctr.12969
– volume: 14
  start-page: 213
  year: 1989
  ident: ref_26
  article-title: Differential sensitivity to cardiotonic drugs of cyclic AMP phosphodiesterases isolated from canine ventricular and sinoatrial-enriched tissues
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/00005344-198908000-00005
– volume: 97
  start-page: 4239
  year: 2000
  ident: ref_48
  article-title: Cardiac fibrosis in mice lacking brain natriuretic peptide
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.070371497
– volume: 30
  start-page: 561
  year: 2017
  ident: ref_60
  article-title: Associations of proatrial natriuretic peptide with components of the metabolic syndrome in adolescents and young adults from the general population
  publication-title: Am. J. Hypertens.
  doi: 10.1093/ajh/hpx026
– volume: 292
  start-page: F1636
  year: 2007
  ident: ref_85
  article-title: Renal hyporesponsiveness to atrial natriuretic peptide in congestive heart failure results from reduced atrial natriuretic peptide receptor concentrations
  publication-title: Am. J. Physiol. Renal Physiol.
  doi: 10.1152/ajprenal.00418.2006
– volume: 35
  start-page: 195
  year: 2014
  ident: ref_23
  article-title: Clinical and molecular genetics of the phosphodiesterases (PDEs)
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2013-1053
– volume: 7
  start-page: 43
  year: 2009
  ident: ref_49
  article-title: Natriuretic peptides in cardiovascular diseases of fetus, infants and children
  publication-title: Cardiovasc. Hematol. Agents Med. Chem.
  doi: 10.2174/187152509787047667
– volume: 102
  start-page: 17442
  year: 2005
  ident: ref_100
  article-title: Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0508782102
– volume: 79
  start-page: 1647
  year: 2015
  ident: ref_17
  article-title: Natriuretic Peptides and Cardiometabolic Health
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-15-0589
– volume: 3
  start-page: R31
  year: 2014
  ident: ref_65
  article-title: The heart as an endocrine organ
  publication-title: Endocr. Connect.
  doi: 10.1530/EC-14-0012
– volume: 21
  start-page: 2756
  year: 2019
  ident: ref_109
  article-title: ACC/AHA Versus ESC Guidelines on Heart Failure: JACC Guideline Comparison
  publication-title: J. Am. Coll. Cardiol.
– volume: 30
  start-page: 875
  year: 1998
  ident: ref_70
  article-title: Tumor necrosis factor-alpha is persistently expressed in cardiac allografts in the absence of histological or clinical evidence of rejection
  publication-title: Transplant. Proc.
  doi: 10.1016/S0041-1345(98)00083-9
– volume: 176
  start-page: 1601
  year: 1991
  ident: ref_47
  article-title: Interaction of atrial natriuretic polypeptide and angiotensin II on protooncogene expression and vascular cell growth
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/0006-291X(91)90471-I
– volume: 522
  start-page: 106
  year: 1988
  ident: ref_28
  article-title: Cyclic nucleotides and calcium regulation in heart and smooth muscle cells
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.1988.tb33348.x
– volume: 62
  start-page: 1596
  year: 2013
  ident: ref_121
  article-title: Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2013.05.057
– volume: 3
  start-page: 207
  year: 2010
  ident: ref_104
  article-title: Plasma soluble corin in patients with heart failure
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.109.903849
– volume: 28
  start-page: 1119
  year: 2009
  ident: ref_74
  article-title: Hypoxia and myocardial remodeling in human cardiac allografts: A time-course study
  publication-title: J. Heart Lung Transplant.
  doi: 10.1016/j.healun.2009.05.038
– volume: 10
  start-page: 1
  year: 2015
  ident: ref_2
  article-title: Fonction endocrine du cœur
  publication-title: EMC Cardiol.
– volume: 15
  start-page: 1011
  year: 1993
  ident: ref_103
  article-title: Characterization of a secreted form of human furin endoprotease
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 63
  start-page: 1110
  year: 2017
  ident: ref_89
  article-title: Development of a BNP1-32 immunoassay that does not cross-react with proBNP
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2016.269712
– volume: 59
  start-page: 2182
  year: 2012
  ident: ref_118
  article-title: Cyclic Adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2012.01.060
– volume: 19
  start-page: 167
  year: 2017
  ident: ref_87
  article-title: Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: Implications for therapy
  publication-title: Eur. J. Heart Fail.
  doi: 10.1002/ejhf.656
– volume: 1
  start-page: 71
  year: 1994
  ident: ref_83
  article-title: Inhibition of cyclic GMP phosphodiesterases augments renal responses to atrial natriuretic factor in congestive heart failure
  publication-title: J. Card. Fail.
  doi: 10.1016/1071-9164(94)90010-8
– volume: 10
  start-page: 31
  year: 2011
  ident: ref_42
  article-title: Altered regulation of renal nitric oxide and atrial natriuretic peptide systems in angiotensin II-induced hypertension
  publication-title: Regul. Pept.
  doi: 10.1016/j.regpep.2011.05.005
– volume: 85
  start-page: 2270
  year: 1998
  ident: ref_69
  article-title: Enhanced brain natriuretic peptide response to peak exercise in heart transplant recipients
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.1998.85.6.2270
– volume: 98
  start-page: 2849
  year: 1988
  ident: ref_61
  article-title: Early impairment of renal hemodynamic reserve in patients with asymptomatic heart failure is restored by angiotensin II antagonism
  publication-title: Circulation
  doi: 10.1161/01.CIR.98.25.2849
– volume: 16
  start-page: 469
  year: 2005
  ident: ref_44
  article-title: The endocrine function of the heart
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2005.10.007
– volume: 56
  start-page: 1166
  year: 2010
  ident: ref_91
  article-title: Processing of pro-B-type natriuretic peptide: Furin and corin as candidate convertases
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2010.143883
– volume: 14
  start-page: 14
  year: 2012
  ident: ref_107
  article-title: Dipeptidyl peptidase IV inhibition improves cardiorenal function in overpacing-induced heart failure
  publication-title: Eur. J. Heart Fail.
  doi: 10.1093/eurjhf/hfr146
– volume: 21
  start-page: e25
  year: 2015
  ident: ref_25
  article-title: Cyclic nucleotide phosphodiesterases: Important signaling modulators and therapeutic targets
  publication-title: Oral Dis.
  doi: 10.1111/odi.12275
– volume: 50
  start-page: 1718
  year: 1996
  ident: ref_84
  article-title: Blunted cGMP response to agonists and enhanced glomerular cyclic 3′, 5′-nucleotide phosphodiesterase activities in experimental congestive heart failure
  publication-title: Kidney Int.
  doi: 10.1038/ki.1996.491
– volume: 267
  start-page: 10551
  year: 1992
  ident: ref_64
  article-title: Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)50052-7
– volume: 389
  start-page: 1139
  year: 2016
  ident: ref_123
  article-title: Phosphodiesterase 2: Anti-adrenergic friend or hypertrophic foe in heart disease?
  publication-title: Naunyn Schmiedebergs Arch. Pharmacol.
  doi: 10.1007/s00210-016-1289-4
– volume: 32
  start-page: 1545
  year: 2009
  ident: ref_54
  article-title: B-type natriuretic peptide-induced cardioprotection against reperfusion is associated with attenuation of mitochondrial permeability transition
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.32.1545
– volume: 141
  start-page: 335
  year: 2014
  ident: ref_51
  article-title: Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development
  publication-title: Development
  doi: 10.1242/dev.100370
– volume: 31
  start-page: 7
  year: 1996
  ident: ref_18
  article-title: Mechanical and neuroendocrine regulation of the endocrine heart
  publication-title: Cardiovasc. Res.
  doi: 10.1016/S0008-6363(95)00121-2
– volume: 63
  start-page: 207
  year: 1988
  ident: ref_77
  article-title: Reversible induction of right ventricular atriopeptin synthesis in hypertrophy due to hypoxia
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.63.1.207
– volume: 18
  start-page: III169
  year: 1991
  ident: ref_66
  article-title: Stretch-secretion coupling in atrial cardiocytes. Dissociation between atrial natriuretic factor release and mechanical activity
  publication-title: Hypertension
– volume: 7
  start-page: 655
  year: 1993
  ident: ref_114
  article-title: Phosphodiesterase III inhibitors: Long-term risks and short-term benefits
  publication-title: Cardiovasc. Drugs Ther.
  doi: 10.1007/BF00877818
– volume: 91
  start-page: 1421
  year: 2001
  ident: ref_20
  article-title: Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: From the regulation of tone to gene expression
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.2001.91.3.1421
– volume: 8
  start-page: 47
  year: 1996
  ident: ref_33
  article-title: Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
  publication-title: Int. J. Impot. Res.
– volume: 6
  start-page: 242
  year: 2018
  ident: ref_34
  article-title: Update on the safety of phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction
  publication-title: Sex. Med. Rev.
  doi: 10.1016/j.sxmr.2017.08.001
– volume: 53
  start-page: 7
  year: 1998
  ident: ref_10
  article-title: Regulation of gene expression in the endocrine heart
  publication-title: Recent. Prog. Horm. Res.
– volume: 96
  start-page: 100
  year: 2005
  ident: ref_35
  article-title: cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000152262.22968.72
– volume: 94
  start-page: 399
  year: 2005
  ident: ref_50
  article-title: Reference values of NT-proBNP serum concentrations in the umbilical cord blood and in healthy neonates and children
  publication-title: Z. Kardiol.
  doi: 10.1007/s00392-005-0246-x
– volume: 33
  start-page: 769
  year: 2003
  ident: ref_86
  article-title: Mechanisms of renal hyporesponsiveness to ANP in heart failure
  publication-title: Eur. J. Clin. Investig.
  doi: 10.1046/j.1365-2362.2003.01222.x
– volume: 104
  start-page: 495
  year: 1991
  ident: ref_30
  article-title: Endothelium-dependent and independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/j.1476-5381.1991.tb12457.x
– volume: 2
  start-page: 198
  year: 2000
  ident: ref_43
  article-title: Natriuretic peptides in the pathophysiology of congestive heart failure
  publication-title: Curr. Cardiol. Rep.
  doi: 10.1007/s11886-000-0069-3
– volume: 14
  start-page: 1345
  year: 2000
  ident: ref_59
  article-title: Natriuretic peptides: A new lipolytic pathway in human adipocytes
  publication-title: FASEB J.
  doi: 10.1096/fasebj.14.10.1345
– volume: 11
  start-page: e006513
  year: 2017
  ident: ref_68
  article-title: Neurohormonal blockade and circulating cardiovascular biomarkers during anthracycline therapy in breast cancer patients: Results from the PRADA (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy) study
  publication-title: J. Am. Heart Assoc.
  doi: 10.1161/JAHA.117.006513
– volume: 6
  start-page: 4
  year: 2014
  ident: ref_78
  article-title: Physiology of natriuretic peptides: The volume overload hypothesis revisited
  publication-title: World. J. Cardiol.
  doi: 10.4330/wjc.v6.i1.4
– volume: 16
  start-page: 796
  year: 1990
  ident: ref_115
  article-title: Involvement of rolipram-sensitive cyclic AMP phosphodiesterase in the regulation of cardiac contraction
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/00005344-199011000-00016
– volume: 274
  start-page: 14926
  year: 1999
  ident: ref_90
  article-title: Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.274.21.14926
– volume: 120
  start-page: 51
  year: 2011
  ident: ref_62
  article-title: Erythropoietin and the heart: Facts and perspectives
  publication-title: Clin. Sci.
  doi: 10.1042/CS20100305
– ident: ref_111
  doi: 10.3390/jcm8070924
– volume: 63
  start-page: 880
  year: 2017
  ident: ref_98
  article-title: Prognostic role of molecular forms of B-Type natriuretic peptide in acute heart failure
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2016.265140
– volume: 30
  start-page: 1084
  year: 2007
  ident: ref_55
  article-title: B-type natriuretic peptide enhances mild hypoxia-induced apoptotic cell death in cardiomyocytes
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.30.1084
– volume: 261
  start-page: R858
  year: 1991
  ident: ref_81
  article-title: Atrial natriuretic peptide and renal cGMP in rats with experimental heart failure
  publication-title: Am. J. Physiol. Regul. Integr. Comp. Physiol.
  doi: 10.1152/ajpregu.1991.261.4.R858
– volume: 27
  start-page: 9863
  year: 1996
  ident: ref_15
  article-title: Molecular determinants of the clearance function of type C receptors of natriuretic peptides
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.16.9863
– volume: 6
  start-page: 1029
  year: 2013
  ident: ref_106
  article-title: Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure
  publication-title: Circ. Heart Fail.
  doi: 10.1161/CIRCHEARTFAILURE.112.000057
– volume: 28
  start-page: 89
  year: 1981
  ident: ref_5
  article-title: A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats
  publication-title: Life Sci.
  doi: 10.1016/0024-3205(81)90370-2
– volume: 35
  start-page: 1743
  year: 1986
  ident: ref_27
  article-title: Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/0006-2952(86)90333-3
– volume: 100
  start-page: 2443
  year: 1999
  ident: ref_82
  article-title: Renal response to acute neutral endopeptidase inhibition in mild and severe experimental heart failure
  publication-title: Circulation
  doi: 10.1161/01.CIR.100.24.2443
– volume: 88
  start-page: 889
  year: 2010
  ident: ref_22
  article-title: NPR-C: A component of the natriuretic peptide family with implications in human diseases
  publication-title: J. Mol. Med. (Berl.)
  doi: 10.1007/s00109-010-0641-2
– volume: 519
  start-page: 472
  year: 2015
  ident: ref_39
  article-title: Phosphodiesterase 9A controls nitric-oxide independent cGMP and hypertrophic heart disease
  publication-title: Nature
  doi: 10.1038/nature14332
– volume: 53
  start-page: 866
  year: 2007
  ident: ref_101
  article-title: The brain natriuretic peptide (BNP) precursor is the major immunoreactive form of BNP in patients with heart failure
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2006.076141
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Title The Endocrine Function of the Heart: Physiology and Involvements of Natriuretic Peptides and Cyclic Nucleotide Phosphodiesterases in Heart Failure
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