Brain Metabolism of Allopregnanolone and Isoallopregnanolone in Male Rat Brain

Allopregnanolone (allo) and isoallopregnanolone (isoallo) are neuroactive steroid epimers that differ in hydroxyl orientation at carbon three. Allo is a potent GABA-A receptor agonist, while isoallo acts as an antagonist, influencing brain function through their interconversion. Their metabolism var...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 26; no. 17; p. 8559
Main Authors:	Öfverman, Charlotte, Hill, Martin, Johansson, Maja, Bäckström, Torbjörn
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 03.09.2025
Subjects:	17β-hydroxysteroid dehydrogenases aldoketoreductases allopregnanolone Animals Brain Brain - metabolism circulation Conversion Enzymes GABA GC-MS hippocampus isoallopregnanolone Liver Male Metabolism Metabolites neuroactive steroids Neurophysiology Physiological aspects Pregnanolone - analogs & derivatives Pregnanolone - metabolism rat Rats Rats, Sprague-Dawley Steroids striatum Sweden GC-MS neuroactive steroids hippocampus rat striatum 17β-hydroxysteroid dehydrogenases circulation isoallopregnanolone allopregnanolone brain aldoketoreductases
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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