Induction of apoptosis by a novel copper-based anticancer compound, Casiopeina II, in L1210 murine leukaemia and CH1 human ovarian carcinoma cells

The activity of casiopeina II [Cu(1,4-dimethyl-1,10-phenanthroline)(glycine)NO 3], a novel anticancer agent, was tested in two cell lines, L1210 murine leukaemia, CH1 human ovarian carcinoma, cisplatin-resistant and sensitive. Exposure of the cells to a range of concentrations of casiopeina II indic...

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Bibliographic Details
Published in:	Toxicology in vitro Vol. 14; no. 1; pp. 1 - 5
Main Authors:	De Vizcaya-Ruiz, A., Rivero-Muller, A., Ruiz-Ramirez, L., Kass, G.E.N., Kelland, L.R., Orr, R.M., Dobrota, M.
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01.02.2000 Elsevier Science
Subjects:	Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Biological and medical sciences cancer chemotherapy casiopeina II Caspases - metabolism CH1 cells copper complexes DNA Fragmentation - drug effects DNA, Neoplasm - analysis DNA, Neoplasm - isolation & purification Enzyme Activation - drug effects Female General aspects Humans L1210 cells Leukemia L1210 - drug therapy Leukemia L1210 - enzymology Leukemia L1210 - pathology Medical sciences Mice Organometallic Compounds - pharmacology Ovarian Neoplasms - drug therapy Ovarian Neoplasms - enzymology Ovarian Neoplasms - pathology Pharmacology. Drug treatments Tumor Cells, Cultured FBS=foetal bovine serum copper complexes PBS=phosphate buffered saline cancer chemotherapy apoptosis Z-VAD-FMK=Z-Val-Ala-DL-Asp-fluoromethylketone Z-DEVD-AFC=Z-Asp-Glu-Val-Asp-7-amino-4-trifluoromethylcoumarin DMEM=Dulbecco's modified Eagle's medium Antineoplastic agent Human Nitrogen heterocycle Rodentia Nitrato complex Organic ligand Cytotoxicity L1210-Leukemia Transition metal Complexes Glycine Copper Complexes In vitro Ovary α-Aminoacid Vertebrata Mammalia Cell line Mouse Cell death Complexes Mixed Animal Mechanism of action Tumor cell Apoptosis
ISSN:	0887-2333, 1879-3177
Online Access:	Get full text
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