Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy
During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavio...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 382; no. 6666; p. 76 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
06.10.2023
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| ISSN: | 1095-9203, 1095-9203 |
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| Abstract | During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of estradiol and progesterone on galanin (Gal)-expressing neurons in the mouse medial preoptic area (MPOA) is critical for pregnancy-induced parental behavior. Whereas estradiol silences MPOA
neurons and paradoxically increases their excitability, progesterone permanently rewires this circuit node by promoting dendritic spine formation and recruitment of excitatory synaptic inputs. This MPOA
-specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. Pregnancy hormones thus remodel parenting circuits in anticipation of future behavioral need. |
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| AbstractList | During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of estradiol and progesterone on galanin (Gal)-expressing neurons in the mouse medial preoptic area (MPOA) is critical for pregnancy-induced parental behavior. Whereas estradiol silences MPOA
neurons and paradoxically increases their excitability, progesterone permanently rewires this circuit node by promoting dendritic spine formation and recruitment of excitatory synaptic inputs. This MPOA
-specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. Pregnancy hormones thus remodel parenting circuits in anticipation of future behavioral need. During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of estradiol and progesterone on galanin (Gal)-expressing neurons in the mouse medial preoptic area (MPOA) is critical for pregnancy-induced parental behavior. Whereas estradiol silences MPOAGal neurons and paradoxically increases their excitability, progesterone permanently rewires this circuit node by promoting dendritic spine formation and recruitment of excitatory synaptic inputs. This MPOAGal-specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. Pregnancy hormones thus remodel parenting circuits in anticipation of future behavioral need.During pregnancy, physiological adaptations prepare the female body for the challenges of motherhood. Becoming a parent also requires behavioral adaptations. Such adaptations can occur as early as during pregnancy, but how pregnancy hormones remodel parenting circuits to instruct preparatory behavioral changes remains unknown. We found that action of estradiol and progesterone on galanin (Gal)-expressing neurons in the mouse medial preoptic area (MPOA) is critical for pregnancy-induced parental behavior. Whereas estradiol silences MPOAGal neurons and paradoxically increases their excitability, progesterone permanently rewires this circuit node by promoting dendritic spine formation and recruitment of excitatory synaptic inputs. This MPOAGal-specific neural remodeling sparsens population activity in vivo and results in persistently stronger, more selective responses to pup stimuli. Pregnancy hormones thus remodel parenting circuits in anticipation of future behavioral need. |
| Author | Ammari, Rachida Nassar, Estelle Kohl, Johannes Wai, Patty Cao, Mingran Del Grosso, Nicholas A Borak, Neven Monaca, Francesco Schneider-Luftman, Deborah Lee, Matthew |
| Author_xml | – sequence: 1 givenname: Rachida orcidid: 0000-0002-1736-6063 surname: Ammari fullname: Ammari, Rachida organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 2 givenname: Francesco orcidid: 0000-0002-2429-8417 surname: Monaca fullname: Monaca, Francesco organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 3 givenname: Mingran orcidid: 0000-0003-0075-1106 surname: Cao fullname: Cao, Mingran organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 4 givenname: Estelle surname: Nassar fullname: Nassar, Estelle organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 5 givenname: Patty orcidid: 0009-0001-8778-8106 surname: Wai fullname: Wai, Patty organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 6 givenname: Nicholas A surname: Del Grosso fullname: Del Grosso, Nicholas A organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 7 givenname: Matthew orcidid: 0009-0007-8106-0935 surname: Lee fullname: Lee, Matthew organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 8 givenname: Neven orcidid: 0000-0001-8822-2537 surname: Borak fullname: Borak, Neven organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK – sequence: 9 givenname: Deborah orcidid: 0000-0001-5821-2135 surname: Schneider-Luftman fullname: Schneider-Luftman, Deborah organization: Bioinformatics and Biostatistics Science Technology Platform, The Francis Crick Institute, London NW1 1AT, UK – sequence: 10 givenname: Johannes orcidid: 0000-0001-8222-0282 surname: Kohl fullname: Kohl, Johannes organization: State-Dependent Neural Processing Laboratory, The Francis Crick Institute, London NW1 1AT, UK |
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| SubjectTerms | Animals Estradiol - physiology Female Maternal Behavior - physiology Maternal Behavior - psychology Mice Models, Animal Neurons - metabolism Neurons - physiology Parenting - psychology Pregnancy Preoptic Area - cytology Preoptic Area - physiology Progesterone - physiology |
| Title | Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy |
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