Role of donor and recipient sex in platelet transfusion

Background H‐Y proteins are ubiquitously expressed Y chromosome‐encoded minor histocompatibility antigens, which are relevant in the transplantation of hematopoietic stem cells (HSCT) and solid organs. No studies have so far analyzed whether H‐Y incompatibility influences the outcome of platelet (PL...

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Podrobná bibliografie
Vydáno v:	Transfusion (Philadelphia, Pa.) Ročník 53; číslo 11; s. 2801 - 2806
Hlavní autoři:	Stern, Martin, Infanti, Laura, O'Meara, Alix, Sigle, Jörg, Buser, Andreas
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken, NJ Blackwell Publishing Ltd 01.11.2013 Wiley Wiley Subscription Services, Inc
Témata:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Donors Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow Female Females H-Y Antigen - immunology Humans Male Medical sciences Middle Aged Platelet Transfusion Sex Characteristics Stem cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Suboptimal donor Human Platelet Recipient Transfusion Sex
ISSN:	0041-1132, 1537-2995, 1537-2995
On-line přístup:	Získat plný text
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Popis
Shrnutí:	Background H‐Y proteins are ubiquitously expressed Y chromosome‐encoded minor histocompatibility antigens, which are relevant in the transplantation of hematopoietic stem cells (HSCT) and solid organs. No studies have so far analyzed whether H‐Y incompatibility influences the outcome of platelet (PLT) transfusion. Study Design and Methods We studied the effect of donor and recipient sex on outcome of 9038 single‐donor PLT transfusions. Results Using standard corrected count increment or percent PLT recovery (PPR) calculations, male patients showed inferior recovery rates, irrespective of donor sex. Using an adjusted PPR, which takes into account differences in blood volume between males and females, neither donor nor recipient sex played any role in PLT recovery after transfusion. Similarly, the time to next PLT transfusion was unaffected by both donor and recipient sex. In a subgroup analysis of patients with graft‐versus‐host disease after allogeneic HSCT, male recipients of a female allograft—which may carry anti‐H‐Y T cells and antibodies—had significantly lower time to next PLT transfusion. However, this occurred after both male donor and female donor PLT transfusions, arguing against an involvement of alloreactivity against H‐Y antigens on PLTs. Conclusion This large analysis found no evidence that donor‐recipient sex matching influences the outcome of PLT transfusion.
Bibliografie:	istex:B56399BA0A948015B7D1F575A2592EA21EA662E1 ArticleID:TRF12136 ark:/67375/WNG-FSQ7D18S-R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0041-1132 1537-2995 1537-2995
DOI:	10.1111/trf.12136