Role of donor and recipient sex in platelet transfusion

Background H‐Y proteins are ubiquitously expressed Y chromosome‐encoded minor histocompatibility antigens, which are relevant in the transplantation of hematopoietic stem cells (HSCT) and solid organs. No studies have so far analyzed whether H‐Y incompatibility influences the outcome of platelet (PL...

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Published in:Transfusion (Philadelphia, Pa.) Vol. 53; no. 11; pp. 2801 - 2806
Main Authors: Stern, Martin, Infanti, Laura, O'Meara, Alix, Sigle, Jörg, Buser, Andreas
Format: Journal Article
Language:English
Published: Hoboken, NJ Blackwell Publishing Ltd 01.11.2013
Wiley
Wiley Subscription Services, Inc
Subjects:
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Blood Donors
Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis
Bone marrow
Female
Females
H-Y Antigen - immunology
Humans
Male
Medical sciences
Middle Aged
Platelet Transfusion
Sex Characteristics
Stem cells
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Suboptimal donor
Human
Platelet
Recipient
Transfusion
Sex
ISSN:0041-1132, 1537-2995, 1537-2995
Online Access:Get full text
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Summary:Background H‐Y proteins are ubiquitously expressed Y chromosome‐encoded minor histocompatibility antigens, which are relevant in the transplantation of hematopoietic stem cells (HSCT) and solid organs. No studies have so far analyzed whether H‐Y incompatibility influences the outcome of platelet (PLT) transfusion. Study Design and Methods We studied the effect of donor and recipient sex on outcome of 9038 single‐donor PLT transfusions. Results Using standard corrected count increment or percent PLT recovery (PPR) calculations, male patients showed inferior recovery rates, irrespective of donor sex. Using an adjusted PPR, which takes into account differences in blood volume between males and females, neither donor nor recipient sex played any role in PLT recovery after transfusion. Similarly, the time to next PLT transfusion was unaffected by both donor and recipient sex. In a subgroup analysis of patients with graft‐versus‐host disease after allogeneic HSCT, male recipients of a female allograft—which may carry anti‐H‐Y T cells and antibodies—had significantly lower time to next PLT transfusion. However, this occurred after both male donor and female donor PLT transfusions, arguing against an involvement of alloreactivity against H‐Y antigens on PLTs. Conclusion This large analysis found no evidence that donor‐recipient sex matching influences the outcome of PLT transfusion.
Bibliography:istex:B56399BA0A948015B7D1F575A2592EA21EA662E1
ArticleID:TRF12136
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ISSN:0041-1132
1537-2995
1537-2995
DOI:10.1111/trf.12136