Enantio- and Diastereoselective Syntheses of 3-Hydroxypiperidines through Iridium-Catalyzed Allylic Substitution

Stereoselective syntheses of 3‐hydroxypiperidines have been developed. Key intermediates are N‐protected allylamines that are prepared by an enantioselective iridium‐catalyzed allylic amination. A subsequent catch and release procedure that involves an epoxidation and base‐mediated elimination yield...

Full description

Saved in:

Bibliographic Details
Published in:	European journal of organic chemistry Vol. 2013; no. 23; pp. 5149 - 5159
Main Authors:	Hoecker, Johannes, Rudolf, Georg C., Bächle, Florian, Fleischer, Steffen, Lindner, Benjamin D., Helmchen, Günter
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01.08.2013 WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc
Subjects:	Alkaloids Amination Azasugars Chemistry Chemistry, Organic Epoxidation Iridium Lactams Nitrogen heterocycles Pharmaceutical industry Physical Sciences Science & Technology Lactams DEOXYMANNOJIRIMYCIN Azasugars Alkaloids CARBONYLATION Nitrogen heterocycles Amination PIPERIDINE Epoxidation ENANTIOSELECTIVE SYNTHESES Iridium STEREOSELECTIVE-SYNTHESIS ASYMMETRIC TOTAL-SYNTHESIS DERIVATIVES EFFICIENT CYCLIZATION
ISSN:	1434-193X, 1099-0690
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!