NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of a defined set of transcription factors requires epigenetic changes in pluripotency genes. Nuclear reprogramming is an inefficient process and the molecular mechanisms that reset the epigenetic state durin...

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Bibliographic Details
Published in:	Stem cells (Dayton, Ohio) Vol. 31; no. 7; pp. 1278 - 1286
Main Authors:	Luo, Min, Ling, Te, Xie, Wenbing, Sun, He, Zhou, Yonggang, Zhu, Qiaoyun, Shen, Meili, Zong, Le, Lyu, Guoliang, Zhao, Yun, Ye, Tao, Gu, Jun, Tao, Wei, Lu, Zhigang, Grummt, Ingrid
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.07.2013 Oxford University Press
Subjects:	Animals Cell Differentiation - physiology Cellular Reprogramming - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryonic Stem Cells - physiology Epigenetic regulation Epigenetics Epigenomics Gene Expression Gene Knockdown Techniques Genes, myc Induced pluripotent stem cells Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - physiology Mbd3/NuRD Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism Mi-2 Nucleosome Remodeling and Deacetylase Complex - physiology Mice Mice, Inbred CBA Nanog Plasmids Promoter Regions, Genetic Reprogramming efficiency SOXB1 Transcription Factors - genetics Stem cells Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Up-Regulation Epigenetic regulation Nanog Induced pluripotent stem cells Mbd3/NuRD Reprogramming efficiency
ISSN:	1066-5099, 1549-4918, 1549-4918
Online Access:	Get full text
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