Curcumin effects on blood lipid profile in a 6-month human study

Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated...

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Vydáno v:	Pharmacological research Ročník 56; číslo 6; s. 509 - 514
Hlavní autoři:	Baum, Larry, Cheung, Stanley K.K., Mok, Vincent C.T., Lam, Linda C.W., Leung, Vivian P.Y., Hui, Elsie, Ng, Chelsia C.Y., Chow, Moses, Ho, Ping C., Lam, Sherry, Woo, Jean, Chiu, Helen F.K., Goggins, William, Zee, Benny, Wong, Adrian, Mok, Hazel, Cheng, William K.F., Fong, Carmen, Lee, Jenny S.W., Chan, Ming-Houng, Szeto, Samuel S.L., Lui, Victor W.C., Tsoh, Joshua, Kwok, Timothy C.Y., Chan, Iris H.S., Lam, Christopher W.K.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier Ltd 01.12.2007
Témata:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - drug therapy Cholesterol Cholesterol - blood Curcumin Curcumin - adverse effects Curcumin - therapeutic use Double-Blind Method Female High-density lipoprotein Humans Low-density lipoprotein Male Middle Aged Triglycerides Triglycerides - blood Low-density lipoprotein Curcumin Triglycerides High-density lipoprotein Cholesterol
ISSN:	1043-6618, 1096-1186
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Abstract	Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects ( n = 36) consumed 4 g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol.
AbstractList	Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol.Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects ( n = 36) consumed 4 g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol.
Author	Woo, Jean Baum, Larry Chiu, Helen F.K. Lui, Victor W.C. Fong, Carmen Goggins, William Tsoh, Joshua Kwok, Timothy C.Y. Mok, Hazel Ng, Chelsia C.Y. Chan, Iris H.S. Cheng, William K.F. Lam, Linda C.W. Hui, Elsie Lam, Christopher W.K. Zee, Benny Wong, Adrian Chan, Ming-Houng Ho, Ping C. Lee, Jenny S.W. Cheung, Stanley K.K. Lam, Sherry Leung, Vivian P.Y. Chow, Moses Mok, Vincent C.T. Szeto, Samuel S.L.
Author_xml	– sequence: 1 givenname: Larry surname: Baum fullname: Baum, Larry email: lwbaum@cuhk.edu.hk organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 2 givenname: Stanley K.K. surname: Cheung fullname: Cheung, Stanley K.K. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 3 givenname: Vincent C.T. surname: Mok fullname: Mok, Vincent C.T. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 4 givenname: Linda C.W. surname: Lam fullname: Lam, Linda C.W. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 5 givenname: Vivian P.Y. surname: Leung fullname: Leung, Vivian P.Y. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 6 givenname: Elsie surname: Hui fullname: Hui, Elsie organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 7 givenname: Chelsia C.Y. surname: Ng fullname: Ng, Chelsia C.Y. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 8 givenname: Moses surname: Chow fullname: Chow, Moses organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 9 givenname: Ping C. surname: Ho fullname: Ho, Ping C. organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 10 givenname: Sherry surname: Lam fullname: Lam, Sherry organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 11 givenname: Jean surname: Woo fullname: Woo, Jean organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 12 givenname: Helen F.K. surname: Chiu fullname: Chiu, Helen F.K. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 13 givenname: William surname: Goggins fullname: Goggins, William organization: School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 14 givenname: Benny surname: Zee fullname: Zee, Benny organization: Centre for Clinical Trials, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 15 givenname: Adrian surname: Wong fullname: Wong, Adrian organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 16 givenname: Hazel surname: Mok fullname: Mok, Hazel organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 17 givenname: William K.F. surname: Cheng fullname: Cheng, William K.F. organization: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 18 givenname: Carmen surname: Fong fullname: Fong, Carmen organization: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 19 givenname: Jenny S.W. surname: Lee fullname: Lee, Jenny S.W. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 20 givenname: Ming-Houng surname: Chan fullname: Chan, Ming-Houng organization: The Department of Medicine and Geriatrics, Kwong Wah Hospital, Kowloon, Hong Kong – sequence: 21 givenname: Samuel S.L. surname: Szeto fullname: Szeto, Samuel S.L. organization: The Department of Medicine and Geriatrics, Kwong Wah Hospital, Kowloon, Hong Kong – sequence: 22 givenname: Victor W.C. surname: Lui fullname: Lui, Victor W.C. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 23 givenname: Joshua surname: Tsoh fullname: Tsoh, Joshua organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 24 givenname: Timothy C.Y. surname: Kwok fullname: Kwok, Timothy C.Y. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 25 givenname: Iris H.S. surname: Chan fullname: Chan, Iris H.S. organization: Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 26 givenname: Christopher W.K. surname: Lam fullname: Lam, Christopher W.K. organization: Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong
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SubjectTerms	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - drug therapy Cholesterol Cholesterol - blood Curcumin Curcumin - adverse effects Curcumin - therapeutic use Double-Blind Method Female High-density lipoprotein Humans Low-density lipoprotein Male Middle Aged Triglycerides Triglycerides - blood
Title	Curcumin effects on blood lipid profile in a 6-month human study
URI	https://dx.doi.org/10.1016/j.phrs.2007.09.013 https://www.ncbi.nlm.nih.gov/pubmed/17951067 https://www.proquest.com/docview/68545304
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