Curcumin effects on blood lipid profile in a 6-month human study
Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated...
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| Veröffentlicht in: | Pharmacological research Jg. 56; H. 6; S. 509 - 514 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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Elsevier Ltd
01.12.2007
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| ISSN: | 1043-6618, 1096-1186 |
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| Abstract | Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (
n
=
36) consumed 4
g/d curcumin, 1
g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490
nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. |
|---|---|
| AbstractList | Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol.Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects (n=36) consumed 4 g/d curcumin, 1g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects ( n = 36) consumed 4 g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol. |
| Author | Woo, Jean Baum, Larry Chiu, Helen F.K. Lui, Victor W.C. Fong, Carmen Goggins, William Tsoh, Joshua Kwok, Timothy C.Y. Mok, Hazel Ng, Chelsia C.Y. Chan, Iris H.S. Cheng, William K.F. Lam, Linda C.W. Hui, Elsie Lam, Christopher W.K. Zee, Benny Wong, Adrian Chan, Ming-Houng Ho, Ping C. Lee, Jenny S.W. Cheung, Stanley K.K. Lam, Sherry Leung, Vivian P.Y. Chow, Moses Mok, Vincent C.T. Szeto, Samuel S.L. |
| Author_xml | – sequence: 1 givenname: Larry surname: Baum fullname: Baum, Larry email: lwbaum@cuhk.edu.hk organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 2 givenname: Stanley K.K. surname: Cheung fullname: Cheung, Stanley K.K. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 3 givenname: Vincent C.T. surname: Mok fullname: Mok, Vincent C.T. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 4 givenname: Linda C.W. surname: Lam fullname: Lam, Linda C.W. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 5 givenname: Vivian P.Y. surname: Leung fullname: Leung, Vivian P.Y. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 6 givenname: Elsie surname: Hui fullname: Hui, Elsie organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 7 givenname: Chelsia C.Y. surname: Ng fullname: Ng, Chelsia C.Y. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 8 givenname: Moses surname: Chow fullname: Chow, Moses organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 9 givenname: Ping C. surname: Ho fullname: Ho, Ping C. organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 10 givenname: Sherry surname: Lam fullname: Lam, Sherry organization: Drug Development Centre, School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 11 givenname: Jean surname: Woo fullname: Woo, Jean organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 12 givenname: Helen F.K. surname: Chiu fullname: Chiu, Helen F.K. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 13 givenname: William surname: Goggins fullname: Goggins, William organization: School of Public Health, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 14 givenname: Benny surname: Zee fullname: Zee, Benny organization: Centre for Clinical Trials, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 15 givenname: Adrian surname: Wong fullname: Wong, Adrian organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 16 givenname: Hazel surname: Mok fullname: Mok, Hazel organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 17 givenname: William K.F. surname: Cheng fullname: Cheng, William K.F. organization: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 18 givenname: Carmen surname: Fong fullname: Fong, Carmen organization: Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 19 givenname: Jenny S.W. surname: Lee fullname: Lee, Jenny S.W. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 20 givenname: Ming-Houng surname: Chan fullname: Chan, Ming-Houng organization: The Department of Medicine and Geriatrics, Kwong Wah Hospital, Kowloon, Hong Kong – sequence: 21 givenname: Samuel S.L. surname: Szeto fullname: Szeto, Samuel S.L. organization: The Department of Medicine and Geriatrics, Kwong Wah Hospital, Kowloon, Hong Kong – sequence: 22 givenname: Victor W.C. surname: Lui fullname: Lui, Victor W.C. organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 23 givenname: Joshua surname: Tsoh fullname: Tsoh, Joshua organization: Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 24 givenname: Timothy C.Y. surname: Kwok fullname: Kwok, Timothy C.Y. organization: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 25 givenname: Iris H.S. surname: Chan fullname: Chan, Iris H.S. organization: Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong – sequence: 26 givenname: Christopher W.K. surname: Lam fullname: Lam, Christopher W.K. organization: Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17951067$$D View this record in MEDLINE/PubMed |
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| Keywords | Low-density lipoprotein Curcumin Triglycerides High-density lipoprotein Cholesterol |
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| References | Lim, Chu, Yang, Beech, Frautschy, Cole (bib4) 2001; 21 Sharma, Euden, Platton, Cooke, Shafayat, Hewitt (bib17) 2004; 10 Soudamini, Unnikrishnan, Soni, Kuttan (bib7) 1992; 36 Peschel, Koerting, Nass (bib12) 2007; 18 Wang, Pan, Cheng, Lin, Ho, Hsieh (bib18) 1997; 15 Soni, Kuttan (bib8) 1992; 36 McKhann, Drachman, Folstein, Katzman, Price, Stadlan (bib9) 1984; 34 Arafa (bib5) 2005; 11 Asai, Miyazawa (bib16) 2000; 67 Vickers, Altman (bib11) 2001; 323 Mazza, Capuano, Bria, Mazza (bib10) 2006; 13 Drieu, Vranckx, Benassayad, Haourigi, Hassid, Yoa (bib13) 2000; 63 Yao, Han, Drieu, Papadopoulos (bib14) 2004; 15 Araujo, Leon (bib1) 2001; 96 Pan, Huang, Lin (bib15) 1999; 27 Maheshwari, Singh, Gaddipati, Srimal (bib2) 2006; 78 Ramirez-Tortosa, Mesa, Aguilera, Quiles, Baro, Ramirez-Tortosa (bib6) 1999; 147 Frautschy, Hu, Kim, Miller, Chu, Harris-White (bib3) 2001; 22 Ireson, Orr, Jones, Verschoyle, Lim, Luo (bib19) 2001; 61 |
| References_xml | – volume: 22 start-page: 993 year: 2001 end-page: 1005 ident: bib3 article-title: Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology publication-title: Neurobiol Aging – volume: 61 start-page: 1058 year: 2001 end-page: 1064 ident: bib19 article-title: Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production publication-title: Cancer Res – volume: 36 start-page: 273 year: 1992 end-page: 275 ident: bib8 article-title: Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers publication-title: Indian J Physiol Pharmacol – volume: 15 start-page: 749 year: 2004 end-page: 756 ident: bib14 article-title: Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels publication-title: J Nutr Biochem – volume: 67 start-page: 2785 year: 2000 end-page: 2793 ident: bib16 article-title: Occurrence of orally administered curcuminoid as glucuronide and glucuronide/sulfate conjugates in rat plasma publication-title: Life Sci – volume: 147 start-page: 371 year: 1999 end-page: 378 ident: bib6 article-title: Oral administration of a turmeric extract inhibits LDL oxidation and has hypocholesterolemic effects in rabbits with experimental atherosclerosis publication-title: Atherosclerosis – volume: 21 start-page: 8370 year: 2001 end-page: 8377 ident: bib4 article-title: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse publication-title: J Neurosci – volume: 10 start-page: 6847 year: 2004 end-page: 6854 ident: bib17 article-title: Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance publication-title: Clin Cancer Res – volume: 11 start-page: BR228 year: 2005 end-page: BR234 ident: bib5 article-title: Curcumin attenuates diet-induced hypercholesterolemia in rats publication-title: Med Sci Monit – volume: 13 start-page: 981 year: 2006 end-page: 985 ident: bib10 article-title: Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study publication-title: Eur J Neurol – volume: 18 start-page: 113 year: 2007 end-page: 119 ident: bib12 article-title: Curcumin induces changes in expression of genes involved in cholesterol homeostasis publication-title: J Nutr Biochem – volume: 323 start-page: 1123 year: 2001 end-page: 1124 ident: bib11 article-title: Statistics notes: Analysing controlled trials with baseline and follow up measurements publication-title: BMJ – volume: 34 start-page: 939 year: 1984 end-page: 944 ident: bib9 article-title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease publication-title: Neurology – volume: 36 start-page: 239 year: 1992 end-page: 243 ident: bib7 article-title: Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin publication-title: Indian J Physiol Pharmacol – volume: 78 start-page: 2081 year: 2006 end-page: 2087 ident: bib2 article-title: Multiple biological activities of curcumin: a short review publication-title: Life Sci – volume: 15 start-page: 1867 year: 1997 end-page: 1876 ident: bib18 article-title: Stability of curcumin in buffer solutions and characterization of its degradation products publication-title: J Pharm Biomed Anal – volume: 27 start-page: 486 year: 1999 end-page: 494 ident: bib15 article-title: Biotransformation of curcumin through reduction and glucuronidation in mice publication-title: Drug Metab Dispos – volume: 96 start-page: 723 year: 2001 end-page: 728 ident: bib1 article-title: Biological activities of publication-title: Mem Inst Oswaldo Cruz – volume: 63 start-page: 293 year: 2000 end-page: 300 ident: bib13 article-title: Effect of the extract of publication-title: Prostaglandins Leukot Essent Fatty Acids |
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| SubjectTerms | Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - drug therapy Cholesterol Cholesterol - blood Curcumin Curcumin - adverse effects Curcumin - therapeutic use Double-Blind Method Female High-density lipoprotein Humans Low-density lipoprotein Male Middle Aged Triglycerides Triglycerides - blood |
| Title | Curcumin effects on blood lipid profile in a 6-month human study |
| URI | https://dx.doi.org/10.1016/j.phrs.2007.09.013 https://www.ncbi.nlm.nih.gov/pubmed/17951067 https://www.proquest.com/docview/68545304 |
| Volume | 56 |
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