Curcumin effects on blood lipid profile in a 6-month human study

Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated...

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Vydáno v:Pharmacological research Ročník 56; číslo 6; s. 509 - 514
Hlavní autoři: Baum, Larry, Cheung, Stanley K.K., Mok, Vincent C.T., Lam, Linda C.W., Leung, Vivian P.Y., Hui, Elsie, Ng, Chelsia C.Y., Chow, Moses, Ho, Ping C., Lam, Sherry, Woo, Jean, Chiu, Helen F.K., Goggins, William, Zee, Benny, Wong, Adrian, Mok, Hazel, Cheng, William K.F., Fong, Carmen, Lee, Jenny S.W., Chan, Ming-Houng, Szeto, Samuel S.L., Lui, Victor W.C., Tsoh, Joshua, Kwok, Timothy C.Y., Chan, Iris H.S., Lam, Christopher W.K.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier Ltd 01.12.2007
Témata:
Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - drug therapy
Cholesterol
Cholesterol - blood
Curcumin
Curcumin - adverse effects
Curcumin - therapeutic use
Double-Blind Method
Female
High-density lipoprotein
Humans
Low-density lipoprotein
Male
Middle Aged
Triglycerides
Triglycerides - blood
Low-density lipoprotein
Curcumin
Triglycerides
High-density lipoprotein
Cholesterol
ISSN:1043-6618, 1096-1186
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Shrnutí:Studies in animals and a short-term human study have suggested that curcumin, a polyphenolic compound concentrated in the curry spice turmeric, decreases serum cholesterol concentration. However, no controlled human trials have examined the effect of curcumin on cholesterol. This study investigated the effects of consuming curcumin on the serum lipid profile in men and women. Elderly subjects ( n = 36) consumed 4 g/d curcumin, 1 g/d curcumin, or placebo in a 6-month, randomized, double-blind trial. Plasma curcumin and its metabolites were measured at 1 month, and the serum lipid profile was measured at baseline, 1 month, and 6 months. The plasma curcumin concentration reached a mean of 490 nmol/L. The curcumin concentration was greater after capsule than powder administration. Consumption of either dose of curcumin did not significantly affect triacylglycerols, or total, LDL, and HDL cholesterol over 1 month or 6 months. However, the concentrations of plasma curcumin and serum cholesterol were positively and significantly correlated. Curcumin consumption does not appear to have a significant effect on the serum lipid profile, unless the absorbed concentration of curcumin is considered, in which case curcumin may modestly increase cholesterol.
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ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2007.09.013