Modeling of Diffusion with Partitioning in Stratum Corneum Using a Finite Element Model

Partitioning and diffusion of chemicals in skin is of interest to researchers in areas such as transdermal penetration and drug disposition, either for risk assessment or transdermal delivery. In this study a finite element method is used to model diffusion in the skin's outermost layer, the st...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Annals of biomedical engineering Ročník 33; číslo 9; s. 1281 - 1292
Hlavní autoři: Barbero, Ana M., Frasch, H. F.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Springer Nature B.V 01.09.2005
Témata:
Administration, Cutaneous
Algorithms
Animals
Biological Transport - physiology
Diffusion
Epidermis
Finite Element Analysis
Humans
Models, Biological
Risk assessment
Skin Absorption - physiology
Software
Thermal analysis
ISSN:0090-6964, 1573-9686
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Partitioning and diffusion of chemicals in skin is of interest to researchers in areas such as transdermal penetration and drug disposition, either for risk assessment or transdermal delivery. In this study a finite element method is used to model diffusion in the skin's outermost layer, the stratum corneum (SC). The SC is considered to be a finite two-dimensional composite having different diffusivity values in each medium as well as a partition coefficient at the interfaces between media. A commercial finite element package with thermal analysis capabilities is selected due to the flexibility of this software to handle irregular geometries. Partitioning is accommodated through a change of variables technique. This technique is validated by comparison of model results with analytical solutions of steady-state flux, transient concentration profiles, and time lag for diffusion in laminates. Two applications are presented. Diffusion is solved in a two-dimensional "brick and mortar" geometry that is a simplification of human stratum corneum, with a partition coefficient between corneocyte and lipid. Results are compared to the diffusion in multiple laminates to examine effects of the partition coefficient. The second application is the modeling of diffusion with partitioning through an irregular geometry which is obtained from a micrograph of hairless mouse stratum corneum.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ISSN:0090-6964
1573-9686
DOI:10.1007/s10439-005-5591-4