Eosinophils in chronic obstructive pulmonary disease
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterised by chronic respiratory symptoms, fixed airway obstruction and persistent inflammation that leads to a progressive airflow limitation. Although COPD has traditionally been linked to neutrophilic inflammation,...
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| Veröffentlicht in: | Therapeutic advances in respiratory disease Jg. 19; S. 17534666251335800 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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England
SAGE Publications
01.01.2025
SAGE Publishing |
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| ISSN: | 1753-4666, 1753-4658, 1753-4666 |
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| Abstract | Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterised by chronic respiratory symptoms, fixed airway obstruction and persistent inflammation that leads to a progressive airflow limitation. Although COPD has traditionally been linked to neutrophilic inflammation, recent studies have identified a subset of patients – approximately 20%–40% – with elevated eosinophil levels in blood and sputum. Emerging evidence suggests that eosinophilic inflammation has a pivotal role in a subset of COPD patients and may influence disease progression, exacerbation frequency and therapeutic responses. This narrative review provides a comprehensive analysis of the role of eosinophils in COPD with particular attention to their role as biomarkers in blood and sputum. We evaluate the prevalence of eosinophilic inflammation in COPD exanimating different thresholds used in blood and in sputum to define it. In addition, we focus on eosinophilic COPD phenotype as a treatable trait, emphasising recent evidence that supports the effectiveness of biological target therapy. |
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| AbstractList | Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterised by chronic respiratory symptoms, fixed airway obstruction and persistent inflammation that leads to a progressive airflow limitation. Although COPD has traditionally been linked to neutrophilic inflammation, recent studies have identified a subset of patients – approximately 20%–40% – with elevated eosinophil levels in blood and sputum. Emerging evidence suggests that eosinophilic inflammation has a pivotal role in a subset of COPD patients and may influence disease progression, exacerbation frequency and therapeutic responses. This narrative review provides a comprehensive analysis of the role of eosinophils in COPD with particular attention to their role as biomarkers in blood and sputum. We evaluate the prevalence of eosinophilic inflammation in COPD exanimating different thresholds used in blood and in sputum to define it. In addition, we focus on eosinophilic COPD phenotype as a treatable trait, emphasising recent evidence that supports the effectiveness of biological target therapy. Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterised by chronic respiratory symptoms, fixed airway obstruction and persistent inflammation that leads to a progressive airflow limitation. Although COPD has traditionally been linked to neutrophilic inflammation, recent studies have identified a subset of patients - approximately 20%-40% - with elevated eosinophil levels in blood and sputum. Emerging evidence suggests that eosinophilic inflammation has a pivotal role in a subset of COPD patients and may influence disease progression, exacerbation frequency and therapeutic responses. This narrative review provides a comprehensive analysis of the role of eosinophils in COPD with particular attention to their role as biomarkers in blood and sputum. We evaluate the prevalence of eosinophilic inflammation in COPD exanimating different thresholds used in blood and in sputum to define it. In addition, we focus on eosinophilic COPD phenotype as a treatable trait, emphasising recent evidence that supports the effectiveness of biological target therapy.Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous lung condition characterised by chronic respiratory symptoms, fixed airway obstruction and persistent inflammation that leads to a progressive airflow limitation. Although COPD has traditionally been linked to neutrophilic inflammation, recent studies have identified a subset of patients - approximately 20%-40% - with elevated eosinophil levels in blood and sputum. Emerging evidence suggests that eosinophilic inflammation has a pivotal role in a subset of COPD patients and may influence disease progression, exacerbation frequency and therapeutic responses. This narrative review provides a comprehensive analysis of the role of eosinophils in COPD with particular attention to their role as biomarkers in blood and sputum. We evaluate the prevalence of eosinophilic inflammation in COPD exanimating different thresholds used in blood and in sputum to define it. In addition, we focus on eosinophilic COPD phenotype as a treatable trait, emphasising recent evidence that supports the effectiveness of biological target therapy. |
| Author | Visca, Dina Ardesi, Francesco Spanevello, Antonio Vanetti, Marco Zappa, Martina Pignatti, Patrizia |
| Author_xml | – sequence: 1 givenname: Marco orcidid: 0009-0007-3782-5021 surname: Vanetti fullname: Vanetti, Marco organization: Department of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Via Crotto Roncaccio 16, Tradate 12049, Italy, Department of Medicine and Surgery, University of Insubria, via Ravasi 2, Varese 21100, Italy – sequence: 2 givenname: Dina orcidid: 0000-0003-2298-1623 surname: Visca fullname: Visca, Dina organization: Department of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy, Department of Medicine and Surgery, University of Insubria, Varese, Italy – sequence: 3 givenname: Francesco orcidid: 0000-0003-3420-4012 surname: Ardesi fullname: Ardesi, Francesco organization: Department of Medicine and Surgery, University of Insubria, Varese, Italy – sequence: 4 givenname: Martina orcidid: 0000-0001-8443-5316 surname: Zappa fullname: Zappa, Martina organization: Department of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy – sequence: 5 givenname: Patrizia surname: Pignatti fullname: Pignatti, Patrizia organization: Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy – sequence: 6 givenname: Antonio surname: Spanevello fullname: Spanevello, Antonio organization: Department of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy, Department of Medicine and Surgery, University of Insubria, Varese, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40434001$$D View this record in MEDLINE/PubMed |
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| Keywords | type-2 inflammation biologics eosinophil biomarkers COPD |
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| Title | Eosinophils in chronic obstructive pulmonary disease |
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