Modification of p53 protein profile by gamma irradiation followed by methyl donor starvation

The possible beneficial radio-protective effects of one-carbon transfer agents namely folate, choline and methionine have been the subject of extensive investigation. Ionizing radiation is known to extensively damage the DNA. One-carbon transfer agents have been proposed to have important role in co...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 293; no. 1-2; pp. 15 - 21
Main Authors:	Batra, Vipen, Kesavan, Vellappan, Mishra, Kaushala P.
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01.12.2006
Subjects:	Animals Carbon Cell Nucleus - metabolism Cell Nucleus - radiation effects Choline - metabolism Comet Assay Cytoplasm - metabolism Cytoplasm - radiation effects Deoxyribonucleic acid DNA DNA Damage DNA Methylation DNA Repair Dose-Response Relationship, Radiation Folic Acid - metabolism Gamma Rays Heterogeneity Ionizing radiation Irradiation Liver Liver - metabolism Liver - radiation effects Male Methionine - metabolism Mice Spleen Spleen - metabolism Spleen - radiation effects starvation Thymus Gland - metabolism Thymus Gland - radiation effects Tumor Suppressor Protein p53 - metabolism
ISSN:	0300-8177, 1573-4919
Online Access:	Get full text
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