Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins

Can human Sertoli cells cultured in vitro and that have formed an epithelium be used as a model to monitor toxicant-induced junction disruption and to better understand the mechanism(s) by which toxicants disrupt cell adhesion at the Sertoli cell blood-testis barrier (BTB)? Our findings illustrate t...

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Bibliographic Details
Published in:	Human reproduction (Oxford) Vol. 29; no. 6; p. 1279
Main Authors:	Xiao, Xiang, Mruk, Dolores D, Tang, Elizabeth I, Wong, Chris K C, Lee, Will M, John, Constance M, Turek, Paul J, Silvestrini, Bruno, Cheng, C Yan
Format:	Journal Article
Language:	English
Published:	England 01.06.2014
Subjects:	Actins - metabolism Benzhydryl Compounds - pharmacology Cadmium Chloride - pharmacology Cell Adhesion - drug effects Cells, Cultured Environmental Pollutants - pharmacology Humans Male Phenols - pharmacology Sertoli Cells - drug effects Sertoli Cells - metabolism spermatogenesis F-actin human Sertoli cell testis cell adhesion protein
ISSN:	1460-2350, 1460-2350
Online Access:	Get more information
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