Nocturnal Glucose Control with an Artificial Pancreas at a Diabetes Camp

This randomized, crossover trial compared an artificial-pancreas system with a sensor-augmented pump for nocturnal glucose control in young persons with type 1 diabetes at a diabetes camp. The artificial pancreas resulted in less hypoglycemia and tighter glucose control. Intensive insulin therapy is...

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Published in:The New England journal of medicine Vol. 368; no. 9; pp. 824 - 833
Main Authors: Phillip, Moshe, Battelino, Tadej, Atlas, Eran, Kordonouri, Olga, Bratina, Natasa, Miller, Shahar, Biester, Torben, Avbelj Stefanija, Magdalena, Muller, Ido, Nimri, Revital, Danne, Thomas
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 28.02.2013
Subjects:
Adolescent
Automation
Biological and medical sciences
Blood Glucose
Calibration
Camping
Carbohydrates
Child
Control algorithms
Cross-Over Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - therapy
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
General aspects
Glucose
Glycated Hemoglobin A - analysis
Humans
Hypoglycemia
Hypoglycemia - chemically induced
Hypoglycemia - prevention & control
Hypoglycemic Agents - adverse effects
Hypoglycemic Agents - therapeutic use
Insulin
Insulin - adverse effects
Insulin - therapeutic use
Insulin Infusion Systems - adverse effects
Male
Meals
Medical sciences
Pancreas
Pancreas, Artificial - adverse effects
Patients
Sensors
Software
Israel
Endocrinopathy
Medicine
Therapeutic camp
Pancreas
Diabetes mellitus
Glycemia
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:This randomized, crossover trial compared an artificial-pancreas system with a sensor-augmented pump for nocturnal glucose control in young persons with type 1 diabetes at a diabetes camp. The artificial pancreas resulted in less hypoglycemia and tighter glucose control. Intensive insulin therapy is considered to be the standard treatment for tight blood glucose control in patients with type 1 diabetes, since it prevents long-term complications. Several studies have promoted the use of insulin pumps, glucose sensors, or a combination of the two devices (sensor-augmented pump) 1 – 3 to improve glucose control. However, the risk of hypoglycemia is still present with the use of all currently available therapies. 4 – 6 Maintenance of nocturnal euglycemia is extremely important and is challenging, since most cases of severe hypoglycemia occur at night. 7 , 8 Such episodes account for 75% of total hypoglycemic seizures in children 9 and . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1206881