Embryonic origin of the adult hematopoietic system: advances and questions

Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary sourc...

Full description

Saved in:
Bibliographic Details
Published in:Development (Cambridge) Vol. 138; no. 6; p. 1017
Main Authors: Medvinsky, Alexander, Rybtsov, Stanislav, Taoudi, Samir
Format: Journal Article
Language:English
Published: England 15.03.2011
Subjects:
Adult
Animals
Embryo Research
Embryo, Mammalian
Embryonic Development - physiology
Hematopoiesis - physiology
Hematopoietic Stem Cells - physiology
Hematopoietic System - embryology
Humans
Models, Biological
ISSN:1477-9129, 1477-9129
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Definitive hematopoietic stem cells (HSCs) lie at the foundation of the adult hematopoietic system and provide an organism throughout its life with all blood cell types. Several tissues demonstrate hematopoietic activity at early stages of embryonic development, but which tissue is the primary source of these important cells and what are the early embryonic ancestors of definitive HSCs? Here, we review recent advances in the field of HSC research that have shed light on such questions, while setting them into a historical context, and discuss key issues currently circulating in this field.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1477-9129
1477-9129
DOI:10.1242/dev.040998