Recent Advances in the Construction of Spiro Compounds via Radical Dearomatization

The field in dearomatization of aromatic compounds for the construction of spirocycle compounds has been developed rapidly over the last two decades and it provides alternative synthetic method without using extra stoichiometric amounts of chemical oxidants or reductants. In addition, the radical ca...

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Bibliographic Details
Published in:Advanced synthesis & catalysis Vol. 362; no. 21; pp. 4446 - 4461
Main Authors: Yang, Wen‐Chao, Zhang, Ming‐Ming, Feng, Jian‐Guo
Format: Journal Article
Language:English
Published: Heidelberg Wiley Subscription Services, Inc 04.11.2020
Subjects:
Alkenes
Alkynes
Aromatic compounds
Cascade chemical reactions
Chemical bonds
Chemical reactions
cyclization
dearomatization
Oxidizing agents
radical cascade reaction
Radicals
Reducing agents
Spiro compounds
spiro[4,5]trienones
Spirocyclization
sulfone-containing
ISSN:1615-4150, 1615-4169
Online Access:Get full text
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Summary:The field in dearomatization of aromatic compounds for the construction of spirocycle compounds has been developed rapidly over the last two decades and it provides alternative synthetic method without using extra stoichiometric amounts of chemical oxidants or reductants. In addition, the radical cascade reactions of alkenes or alkynes that produce multiple chemical bonds in one‐step are significant in the direct and efficient building of complex molecules. By combining these two concepts, dearomatization and radical cascade reactions of alkenes or alkynes opens a new and powerful avenue in accessing spirocycle molecules. These cascade reactions have been well explored in the past decade. As a result, we summarize recent eventful advances in this rapidly growing area as a review, in which the typical examples are listed and mechanism are also discussed.
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ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000636