Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive ce...

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Bibliographic Details
Published in:Cell proliferation Vol. 54; no. 10; pp. e13115 - n/a
Main Authors: Xu, Maosen, Wang, Yang, Xia, Ruolan, Wei, Yuquan, Wei, Xiawei
Format: Journal Article
Language:English
Published: Chichester John Wiley & Sons, Inc 01.10.2021
John Wiley and Sons Inc
Subjects:
Angiogenesis
Biomarkers
Bone cancer
Breast cancer
Cancer
CC chemokine receptors
CCR2 protein
Cell adhesion & migration
Cell migration
Cervical cancer
Chemokines
Clinical trials
Colorectal cancer
Kidney cancer
Kinases
Ligands
Liver cancer
Medical prognosis
Metastasis
Microenvironments
Monocyte chemoattractant protein 1
Ovarian cancer
Pancreatic cancer
Pathogenesis
Prostate cancer
Proteins
Review
Reviews
Signal transduction
Signaling
Therapeutic targets
Thyroid cancer
Tumor microenvironment
Tumorigenesis
Tumors
ISSN:0960-7722, 1365-2184, 1365-2184
Online Access:Get full text
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Summary:The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive cells to the tumour microenvironment, favouring cancer development. Over the last several decades, a series of studies have been conducted to explore the CCL2‐CCR2 signalling axis function in malignancies. Therapeutic strategies targeting the CCL2‐ CCR2 axis have also shown promising effects, enriching our approaches for fighting against cancer. In this review, we summarize the role of the CCL2‐CCR2 signalling axis in tumorigenesis and highlight recent studies on CCL2‐CCR2 targeted therapy, focusing on preclinical studies and clinical trials. The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. The CCL2‐CCR2 signalling axis plays a critical role in the promotion of pathological angiogenesis, the survival and invasion of tumour cells, and the recruitment of immune inhibitory cells. Therefore, CCL2 and CCR2 enable us to explore the sophisticated mechanisms underlying cancer development and provide potential options for treating malignant tumours.
Bibliography:Maosen Xu and Yang Wang contributed equally to the work.
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ISSN:0960-7722
1365-2184
1365-2184
DOI:10.1111/cpr.13115