Role of the CCL2‐CCR2 signalling axis in cancer: Mechanisms and therapeutic targeting

The chemokine ligand CCL2 and its receptor CCR2 are implicated in the initiation and progression of various cancers. CCL2 can activate tumour cell growth and proliferation through a variety of mechanisms. By interacting with CCR2, CCL2 promotes cancer cell migration and recruits immunosuppressive ce...

Full description

Saved in:

Bibliographic Details
Published in:	Cell proliferation Vol. 54; no. 10; pp. e13115 - n/a
Main Authors:	Xu, Maosen, Wang, Yang, Xia, Ruolan, Wei, Yuquan, Wei, Xiawei
Format:	Journal Article
Language:	English
Published:	Chichester John Wiley & Sons, Inc 01.10.2021 John Wiley and Sons Inc
Subjects:	Angiogenesis Biomarkers Bone cancer Breast cancer Cancer CC chemokine receptors CCR2 protein Cell adhesion & migration Cell migration Cervical cancer Chemokines Clinical trials Colorectal cancer Kidney cancer Kinases Ligands Liver cancer Medical prognosis Metastasis Microenvironments Monocyte chemoattractant protein 1 Ovarian cancer Pancreatic cancer Pathogenesis Prostate cancer Proteins Review Reviews Signal transduction Signaling Therapeutic targets Thyroid cancer Tumor microenvironment Tumorigenesis Tumors
ISSN:	0960-7722, 1365-2184, 1365-2184
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!