Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight

Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN‐DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 ± 7 kg) and BMI increase (+ 4....

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Vydáno v:Movement disorders Ročník 19; číslo 2; s. 206 - 212
Hlavní autoři: Macia, Frédéric, Perlemoine, Caroline, Coman, Irène, Guehl, Dominique, Burbaud, Pierre, Cuny, Emmanuel, Gin, Henri, Rigalleau, Vincent, Tison, François
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2004
Wiley
Témata:
Aged
Antiparkinson Agents - administration & dosage
Antiparkinson Agents - adverse effects
Biological and medical sciences
Body Composition - physiology
Body Mass Index
Combined Modality Therapy
deep brain stimulation
Dominance, Cerebral - physiology
Dyskinesia, Drug-Induced - physiopathology
Dyskinesia, Drug-Induced - therapy
Electric Stimulation Therapy - adverse effects
Energy Metabolism - physiology
Female
Follow-Up Studies
Humans
Levodopa - administration & dosage
Levodopa - adverse effects
Male
Medical sciences
Middle Aged
Neurology
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Prospective Studies
subthalamic nucleus
Subthalamic Nucleus - physiopathology
Treatment Outcome
weight gain
Weight Gain - physiology
Human
Nervous system diseases
Central nervous system disease
Parkinson disease
Degenerative disease
Weight gain
Cerebral disorder
Extrapyramidal syndrome
ISSN:0885-3185, 1531-8257
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Shrnutí:Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN‐DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 ± 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN‐DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN‐DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre‐operative levodopa‐equivalent daily dose, their reduction after STN‐DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN‐DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment. © 2003 Movement Disorder Society
Bibliografie:istex:BA33C88BE28B4E0639853FCF96328D6CE8AF38C5
ArticleID:MDS10630
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ObjectType-Article-1
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ISSN:0885-3185
1531-8257
DOI:10.1002/mds.10630