Oxidative stress-induced cyclin D1 depletion and its role in cell cycle processing

Cyclin D1 is immediately down-regulated in response to reactive oxygen species (ROS) and implicated in the induction of cell cycle arrest in G2 phase by an unknown mechanism. Either treatment with a protease inhibitor alone or expression of protease-resistant cyclin D1 T286A resulted in only a parti...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1830; H. 11; S. 5316 - 5325
Hauptverfasser:	Pyo, Chul-Woong, Choi, Joon Hwan, Oh, Sang-Muk, Choi, Sang-Yun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.11.2013
Schlagworte:	Cell cycle Cell Cycle - genetics Cell Cycle - physiology cell cycle checkpoints Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - physiology Cell Line Cell Line, Tumor Checkpoint Kinase 1 Chk1 Cyclin D1 - genetics Cyclin D1 - metabolism cyclins DNA damage eIF-2 Kinase - genetics eIF-2 Kinase - metabolism G2 Phase - genetics G2 Phase - physiology gene silencing HEK293 Cells HeLa Cells Humans hydrogen peroxide Hydrogen Peroxide - metabolism interphase Oxidative stress Oxidative Stress - genetics Oxidative Stress - physiology Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Proteasome Endopeptidase Complex - physiology Protein Kinases - genetics Protein Kinases - metabolism proteinase inhibitors Proteolysis Reactive Oxygen Species - metabolism Transcription Factors - genetics Transcription Factors - metabolism translation (genetics) Translational repression Ubiquitin - metabolism Oxidative stress Translational repression Chk1 Proteolysis Cell cycle
ISSN:	0304-4165, 0006-3002, 1872-8006
Online-Zugang:	Volltext
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