Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defin...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Journal of investigative dermatology Ročník 139; číslo 7; s. 1516
Hlavní autoři:	Babina, Magda, Wang, Zhao, Franke, Kristin, Guhl, Sven, Artuc, Metin, Zuberbier, Torsten
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2019
Témata:	Cell Cycle Cell Degranulation Cells, Cultured Histamine - biosynthesis Histidine Decarboxylase - metabolism Humans Hypersensitivity - immunology Immunoglobulin E - metabolism Inflammation - immunology Interleukin-33 - metabolism Mast Cells - metabolism Mast Cells - pathology p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Receptors, IgE - metabolism RNA Interference Skin - pathology Skin Diseases - immunology Yin-Yang
ISSN:	1523-1747, 1523-1747
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!