Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation

Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their pronounced receptor expression, MCs are important targets of IL-33 action, but consequences for skin MCs are ill-defin...

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Bibliographic Details
Published in:	Journal of investigative dermatology Vol. 139; no. 7; p. 1516
Main Authors:	Babina, Magda, Wang, Zhao, Franke, Kristin, Guhl, Sven, Artuc, Metin, Zuberbier, Torsten
Format:	Journal Article
Language:	English
Published:	United States 01.07.2019
Subjects:	Cell Cycle Cell Degranulation Cells, Cultured Histamine - biosynthesis Histidine Decarboxylase - metabolism Humans Hypersensitivity - immunology Immunoglobulin E - metabolism Inflammation - immunology Interleukin-33 - metabolism Mast Cells - metabolism Mast Cells - pathology p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Receptors, IgE - metabolism RNA Interference Skin - pathology Skin Diseases - immunology Yin-Yang
ISSN:	1523-1747, 1523-1747
Online Access:	Get more information
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