Epigenetics and cancer

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evid...

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Bibliographic Details
Published in:Genes & development Vol. 18; no. 19; p. 2315
Main Authors: Lund, Anders H, van Lohuizen, Maarten
Format: Journal Article
Language:English
Published: United States 01.10.2004
Subjects:
Cell Cycle - genetics
Cell Differentiation - genetics
Cell Division - genetics
DNA Repair
Gene Expression Regulation
Humans
Neoplasms - blood supply
Neoplasms - genetics
Neoplasms - pathology
Neovascularization, Pathologic
ISSN:0890-9369
Online Access:Get more information
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Summary:Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance. In contrast to genetic cancer causes, the possibility of reversing epigenetic codes may provide new targets for therapeutic intervention.
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ISSN:0890-9369
DOI:10.1101/gad.1232504