N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

Circular RNAs (circRNAs) have been implicated in cancer progression through largely unknown mechanisms. Herein, we identify an N 6 -methyladenosine (m 6 A) modified circRNA, circNSUN2, frequently upregulated in tumor tissues and serum samples from colorectal carcinoma (CRC) patients with liver metas...

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Bibliographic Details
Published in:Nature communications Vol. 10; no. 1; p. 4695
Main Authors: Chen, Ri-Xin, Chen, Xin, Xia, Liang-Ping, Zhang, Jia-Xing, Pan, Zhi-Zhong, Ma, Xiao-Dan, Han, Kai, Chen, Jie-Wei, Judde, Jean-Gabrie, Deas, Olivier, Wang, Feng, Ma, Ning-Fang, Guan, Xinyuan, Yun, Jing-Ping, Wang, Feng-Wei, Xu, Rui-Hua, Dan Xie
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 16.10.2019
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ISSN:2041-1723, 2041-1723
Online Access:Get full text
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