Peripheral nitric oxide signaling directly blocks inflammatory pain

[Display omitted] Pain is a classical sign of inflammation, and sensitization of primary sensory neurons (PSN) is the most important mediating mechanism. This mechanism involves direct action of inflammatory mediators such as prostaglandins and sympathetic amines. Pharmacologic control of inflammato...

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Bibliographic Details
Published in:	Biochemical pharmacology Vol. 176; p. 113862
Main Authors:	Gomes, Francisco Isaac F., Cunha, Fernando Q., Cunha, Thiago M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01.06.2020
Subjects:	Analgesia Inflammatory pain Nitric oxide Nociception PI3Kgamma eNOS GTP ACh K+ATP CXCL1 TNF sGC iNOS ODQ PKGI and PKGII L-NAME TRPV NKA NOARG IL1β PSN PI3Kγ PPARγ CB1 EDRF Nitric oxide L-NIO nNOS GPCR KT5823 L-NMMA CGRP Inflammatory pain NPA NO A1R L-NNA cGMP cAMP DPDPE LPS NSAIDs PI3Kgamma Nociception PGE2 NaV HMG-CoA AKT SNAP Analgesia IL6 TG CPA DRG
ISSN:	0006-2952, 1873-2968, 1873-2968
Online Access:	Get full text
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