Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-de...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 9; H. 1; S. 349 - 365
Hauptverfasser:	Bensaad, Karim, Favaro, Elena, Lewis, Caroline A., Peck, Barrie, Lord, Simon, Collins, Jennifer M., Pinnick, Katherine E., Wigfield, Simon, Buffa, Francesca M., Li, Ji-Liang, Zhang, Qifeng, Wakelam, Michael J.O., Karpe, Fredrik, Schulze, Almut, Harris, Adrian L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier 09.10.2014
Schlagworte:	Cell Hypoxia - physiology Cell Line, Tumor Cell Proliferation - physiology Fatty Acids - metabolism Glioblastoma Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lipid Metabolism Oxidation-Reduction Oxygen - metabolism
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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