microRNAs in action: biogenesis, function and regulation
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to...
Gespeichert in:
| Veröffentlicht in: | Nature reviews. Genetics Jg. 24; H. 12; S. 816 - 833 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Nature Publishing Group
01.12.2023
|
| Schlagworte: | |
| ISSN: | 1471-0056, 1471-0064, 1471-0064 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA machinery, how miRNA substrates and targets are selected from the transcriptome, new avenues for multilevel regulation of miRNA biogenesis and mechanisms for miRNA turnover. Many of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR-Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future. |
|---|---|
| AbstractList | Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA machinery, how miRNA substrates and targets are selected from the transcriptome, new avenues for multilevel regulation of miRNA biogenesis and mechanisms for miRNA turnover. Many of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR–Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future.In this Review, the authors describe how the application of new technologies to the microRNA (miRNA) field has yielded key insights into miRNA biology. The authors summarize our current understanding of miRNA biogenesis, function and processing, and highlight challenges to address in future research. Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA machinery, how miRNA substrates and targets are selected from the transcriptome, new avenues for multilevel regulation of miRNA biogenesis and mechanisms for miRNA turnover. Many of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR-Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future. Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA machinery, how miRNA substrates and targets are selected from the transcriptome, new avenues for multilevel regulation of miRNA biogenesis and mechanisms for miRNA turnover. Many of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR-Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future.Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the universe of small regulatory RNAs. Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA machinery, how miRNA substrates and targets are selected from the transcriptome, new avenues for multilevel regulation of miRNA biogenesis and mechanisms for miRNA turnover. Many of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR-Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future. |
| Author | Lai, Eric C Lee, Seungjae Senavirathne, Gayan Shang, Renfu |
| Author_xml | – sequence: 1 givenname: Renfu surname: Shang fullname: Shang, Renfu organization: Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA – sequence: 2 givenname: Seungjae orcidid: 0000-0001-5626-9656 surname: Lee fullname: Lee, Seungjae organization: Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA – sequence: 3 givenname: Gayan surname: Senavirathne fullname: Senavirathne, Gayan organization: Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA – sequence: 4 givenname: Eric C orcidid: 0000-0002-8432-5851 surname: Lai fullname: Lai, Eric C email: laie@mskcc.org organization: Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA. laie@mskcc.org |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37380761$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkMtKAzEUhoNU7EVfwIUMuHHh6MllMom7UrxBURBdD0kmU1JmkjrpLPr2plpduDrnP3z8fJwpGvngLULnGG4wUHEbGS5KngOhOQDHON8doQlmJd5HNvrbCz5G0xjXAJjjkp6gMS2pgJLjCRKdM314e5nHzPlMma0L_i7TLqyst9HF66wZ_Pc1U77OersaWrWPp-i4UW20Z4c5Qx8P9--Lp3z5-vi8mC9zw7Dc5pKUChgFIahlhGsiC54siC4K1kitakUEEEuJkTXWgMGYxhAqpE5Jm5rO0NVP76YPn4ON26pz0di2Vd6GIVZEUJxKWckSevkPXYeh98kuUUIKSBYkURcHatCdratN7zrV76rfn9AvT_ljJw |
| CitedBy_id | crossref_primary_10_1016_j_prp_2024_155478 crossref_primary_10_1016_j_pt_2025_06_004 crossref_primary_10_1038_s41401_025_01484_z crossref_primary_10_3390_ijms242216213 crossref_primary_10_3390_genes15091239 crossref_primary_10_3390_cancers17142315 crossref_primary_10_1007_s12015_024_10794_4 crossref_primary_10_1038_s44319_024_00315_2 crossref_primary_10_1016_j_ncrna_2024_11_006 crossref_primary_10_1016_j_cyto_2024_156624 crossref_primary_10_3390_cells14070553 crossref_primary_10_1111_jse_13158 crossref_primary_10_1038_s41467_024_53322_1 crossref_primary_10_3390_biomedicines12061360 crossref_primary_10_1080_14756366_2025_2468853 crossref_primary_10_1016_j_aca_2025_343689 crossref_primary_10_1186_s12916_025_04324_3 crossref_primary_10_1039_D4AY02280G crossref_primary_10_1080_17520363_2025_2520160 crossref_primary_10_1016_j_actatropica_2025_107674 crossref_primary_10_1038_s41467_024_52568_z crossref_primary_10_1016_j_yexcr_2024_114234 crossref_primary_10_1021_jacs_4c08719 crossref_primary_10_15420_ecr_2025_34 crossref_primary_10_1016_j_jare_2025_05_056 crossref_primary_10_1016_j_bbrc_2024_149937 crossref_primary_10_1080_17501911_2025_2467021 crossref_primary_10_1007_s10142_024_01489_7 crossref_primary_10_3892_mmr_2025_13575 crossref_primary_10_1177_0271678X251348816 crossref_primary_10_1007_s40843_024_3048_0 crossref_primary_10_1080_15476286_2025_2538271 crossref_primary_10_3389_fgene_2023_1320185 crossref_primary_10_1007_s00210_025_03893_7 crossref_primary_10_3892_etm_2025_12835 crossref_primary_10_1016_j_arr_2024_102278 crossref_primary_10_1177_22143602251348753 crossref_primary_10_1002_1878_0261_13744 crossref_primary_10_1261_rna_080021_124 crossref_primary_10_1038_s41413_025_00430_3 crossref_primary_10_1007_s42764_024_00135_7 crossref_primary_10_2147_IJN_S441133 crossref_primary_10_1186_s12935_025_03895_8 crossref_primary_10_1080_17576180_2025_2535953 crossref_primary_10_1210_endocr_bqad111 crossref_primary_10_3389_fpls_2024_1460540 crossref_primary_10_3390_biology13010015 crossref_primary_10_1021_acsami_4c14928 crossref_primary_10_1016_j_prp_2024_155102 crossref_primary_10_1186_s12964_025_02173_4 crossref_primary_10_1016_j_neuint_2025_106033 crossref_primary_10_3389_fimmu_2023_1228458 crossref_primary_10_32604_or_2024_049235 crossref_primary_10_1007_s10528_025_11168_2 crossref_primary_10_1016_j_ijbiomac_2025_145025 crossref_primary_10_1016_j_biopha_2024_117294 crossref_primary_10_1161_HYPERTENSIONAHA_124_23573 crossref_primary_10_1016_j_bbadis_2024_167098 crossref_primary_10_3390_pharmaceutics17040471 crossref_primary_10_3390_biomedicines13081895 crossref_primary_10_1002_jcsm_13823 crossref_primary_10_3389_fimmu_2025_1602252 crossref_primary_10_1360_SSV_2024_0342 crossref_primary_10_2147_IJN_S524558 crossref_primary_10_3390_ijms25031502 crossref_primary_10_3390_ijms251910701 crossref_primary_10_1016_j_brainresbull_2025_111345 crossref_primary_10_1007_s00018_023_05090_2 crossref_primary_10_1016_j_bcp_2025_116745 crossref_primary_10_1021_acs_est_4c10724 crossref_primary_10_4251_wjgo_v17_i5_104076 crossref_primary_10_1038_s41576_023_00662_1 crossref_primary_10_3390_horticulturae11020141 crossref_primary_10_1038_s41380_025_03167_x crossref_primary_10_4103_NRR_NRR_D_24_00696 crossref_primary_10_1007_s12672_025_02246_3 crossref_primary_10_1002_smsc_202400261 crossref_primary_10_1002_ame2_70076 crossref_primary_10_1016_j_jbc_2023_105499 crossref_primary_10_1186_s12872_024_04465_y crossref_primary_10_3390_dna4020006 crossref_primary_10_1016_j_yexcr_2024_114279 crossref_primary_10_1002_adfm_202502250 crossref_primary_10_1016_j_cej_2024_150631 crossref_primary_10_3390_molecules29245835 crossref_primary_10_1016_j_bbrc_2024_151069 crossref_primary_10_1038_s42003_024_06555_1 crossref_primary_10_1007_s10565_024_09927_9 crossref_primary_10_1186_s12951_025_03337_7 crossref_primary_10_1016_j_lfs_2024_123084 crossref_primary_10_3168_jds_2024_26210 crossref_primary_10_1007_s12291_025_01343_y crossref_primary_10_1016_j_atherosclerosis_2024_119069 crossref_primary_10_1186_s13045_025_01671_9 crossref_primary_10_1016_j_prp_2023_155085 crossref_primary_10_3892_mmr_2025_13667 crossref_primary_10_1007_s11105_024_01513_x crossref_primary_10_3390_ncrna11040051 crossref_primary_10_1038_s41598_023_46562_6 crossref_primary_10_1016_j_jhazmat_2025_138737 crossref_primary_10_1016_j_talanta_2025_128049 crossref_primary_10_1016_j_ijbiomac_2024_135370 crossref_primary_10_4103_neurol_india_Neurol_India_D_24_00920 crossref_primary_10_1016_j_compeleceng_2025_110242 crossref_primary_10_3390_cimb46110741 crossref_primary_10_3390_ncrna11010003 crossref_primary_10_1016_j_molcel_2024_09_008 crossref_primary_10_1038_s41586_025_09256_9 crossref_primary_10_3390_v17030399 crossref_primary_10_3390_ijms25116168 crossref_primary_10_1016_j_lfs_2024_123064 crossref_primary_10_1016_j_tig_2025_06_005 crossref_primary_10_1177_11795549251331755 crossref_primary_10_1007_s11259_025_10727_7 crossref_primary_10_3390_ijms242216052 crossref_primary_10_1016_j_ijbiomac_2025_145674 crossref_primary_10_3389_fonc_2024_1498139 crossref_primary_10_3389_fcell_2024_1331074 crossref_primary_10_3892_ijmm_2025_5531 crossref_primary_10_1002_jbt_70532 crossref_primary_10_3390_biom15050644 crossref_primary_10_1016_j_asems_2025_100158 crossref_primary_10_1631_jzus_B2400032 crossref_primary_10_1007_s10735_024_10327_w crossref_primary_10_1186_s12915_025_02306_8 crossref_primary_10_1261_rna_080108_124 crossref_primary_10_1016_j_aqrep_2025_102653 crossref_primary_10_1016_j_tem_2024_10_002 crossref_primary_10_1167_iovs_66_3_27 crossref_primary_10_1007_s00210_024_03347_6 crossref_primary_10_1007_s00705_024_05992_x crossref_primary_10_1016_j_tig_2024_12_009 crossref_primary_10_1038_s12276_024_01239_6 crossref_primary_10_1038_s41368_025_00349_9 crossref_primary_10_1038_s41598_024_74477_3 crossref_primary_10_3390_ijms251910325 crossref_primary_10_1016_j_celrep_2025_116243 crossref_primary_10_3389_fgene_2024_1381917 crossref_primary_10_1016_j_seminoncol_2025_152386 crossref_primary_10_3390_ijms26188879 crossref_primary_10_1007_s11033_024_09938_z crossref_primary_10_1038_s41598_025_91100_1 crossref_primary_10_1007_s10792_025_03701_4 crossref_primary_10_1186_s12920_025_02158_9 crossref_primary_10_1002_jgm_70019 crossref_primary_10_3390_biom15081189 crossref_primary_10_1016_j_bbrep_2025_102197 crossref_primary_10_1016_j_tibs_2023_09_002 crossref_primary_10_3390_cells13231935 crossref_primary_10_2147_DDDT_S513371 crossref_primary_10_1007_s10142_025_01585_2 crossref_primary_10_1016_j_ecoenv_2025_117800 crossref_primary_10_3389_fcvm_2025_1546515 crossref_primary_10_1186_s12943_025_02298_7 crossref_primary_10_3390_biology14091289 crossref_primary_10_1038_s41392_023_01669_0 crossref_primary_10_1007_s43032_024_01703_8 crossref_primary_10_3389_fmolb_2025_1647300 crossref_primary_10_1140_epjs_s11734_025_01475_5 crossref_primary_10_1002_advs_202415341 crossref_primary_10_3389_fmolb_2024_1385586 crossref_primary_10_1016_j_jrras_2025_101877 crossref_primary_10_1038_s41598_025_07860_3 crossref_primary_10_1039_D4SD00373J crossref_primary_10_1093_nar_gkae416 crossref_primary_10_1080_15412555_2025_2493701 crossref_primary_10_1038_s41598_025_98939_4 crossref_primary_10_1016_j_labinv_2025_104199 crossref_primary_10_3390_brainsci15070756 crossref_primary_10_1038_s42003_025_08721_5 crossref_primary_10_1016_j_talanta_2024_127078 crossref_primary_10_1016_j_tips_2024_03_006 crossref_primary_10_1002_adhm_202404398 crossref_primary_10_3390_plants14010136 crossref_primary_10_3389_dyst_2025_14224 crossref_primary_10_1016_j_prerep_2025_100035 crossref_primary_10_1186_s12957_025_03719_z crossref_primary_10_1016_j_cbpa_2024_102502 crossref_primary_10_1016_j_snb_2024_135389 crossref_primary_10_1038_s41419_024_07286_1 crossref_primary_10_1093_narmme_ugaf022 crossref_primary_10_3390_diagnostics14171981 crossref_primary_10_4103_jioh_jioh_284_24 crossref_primary_10_1261_rna_080338_124 crossref_primary_10_3389_fcvm_2025_1518022 crossref_primary_10_1186_s12958_024_01303_w crossref_primary_10_1055_a_2494_2233 crossref_primary_10_1126_science_adp9388 crossref_primary_10_1016_j_bcp_2025_117216 crossref_primary_10_1016_j_prp_2024_155093 crossref_primary_10_1093_nar_gkae1036 crossref_primary_10_1016_j_ijbiomac_2025_145614 crossref_primary_10_1016_j_cellsig_2025_111745 crossref_primary_10_3389_fnut_2025_1535498 crossref_primary_10_3390_biomedicines13051171 crossref_primary_10_1016_j_bbagrm_2024_195059 crossref_primary_10_3390_life14111431 crossref_primary_10_1016_j_jnutbio_2024_109714 crossref_primary_10_1096_fj_202400306R crossref_primary_10_1016_j_psychres_2025_116465 crossref_primary_10_1053_j_seminhematol_2024_03_001 crossref_primary_10_1007_s12035_025_04750_7 crossref_primary_10_1016_j_bbadis_2025_167664 crossref_primary_10_1016_j_canlet_2024_216655 crossref_primary_10_1128_mbio_01375_25 crossref_primary_10_1186_s10020_023_00776_6 crossref_primary_10_3389_fnmol_2024_1462769 crossref_primary_10_1038_s41540_024_00367_z crossref_primary_10_1021_acs_analchem_5c01674 crossref_primary_10_3389_fimmu_2025_1552665 crossref_primary_10_3390_neuroglia6020022 crossref_primary_10_1002_advs_202506830 crossref_primary_10_1007_s10142_025_01544_x crossref_primary_10_1073_pnas_2306727120 crossref_primary_10_1016_j_ejphar_2025_177344 crossref_primary_10_3390_biom13111677 crossref_primary_10_1016_j_addr_2025_115639 crossref_primary_10_1097_MOH_0000000000000803 crossref_primary_10_1016_j_molpha_2024_100006 crossref_primary_10_1161_CIRCRESAHA_124_325573 crossref_primary_10_1186_s12885_025_13672_5 crossref_primary_10_1038_s41598_024_73000_y crossref_primary_10_1002_jbt_70361 crossref_primary_10_1186_s12951_025_03528_2 crossref_primary_10_1186_s13046_025_03354_2 crossref_primary_10_1007_s11033_025_11015_y crossref_primary_10_1016_j_omtn_2025_102450 crossref_primary_10_1038_s41597_024_03909_6 crossref_primary_10_1007_s00438_024_02183_w crossref_primary_10_3390_genes15121649 crossref_primary_10_1186_s12967_023_04816_x crossref_primary_10_1038_s41598_024_66117_7 crossref_primary_10_1016_j_omtn_2024_102281 crossref_primary_10_1016_j_exer_2025_110236 crossref_primary_10_1016_j_bbrc_2025_151958 crossref_primary_10_1007_s11033_024_10208_1 crossref_primary_10_1016_j_heliyon_2024_e36282 crossref_primary_10_1039_D5AY01227A crossref_primary_10_1016_j_ijbiomac_2024_136820 crossref_primary_10_1016_j_jep_2025_120175 crossref_primary_10_3390_biomedicines13030725 crossref_primary_10_3390_cells14050368 crossref_primary_10_1093_nar_gkae792 crossref_primary_10_1016_j_bbadis_2025_167984 crossref_primary_10_1016_j_bios_2024_117106 crossref_primary_10_1111_liv_15906 crossref_primary_10_3390_cells14040312 crossref_primary_10_1111_mec_17749 crossref_primary_10_1111_nph_20287 crossref_primary_10_1186_s12933_024_02405_w crossref_primary_10_3390_genes16030262 crossref_primary_10_1002_admt_202301570 crossref_primary_10_3390_gastroent16010005 crossref_primary_10_1093_nutrit_nuaf023 crossref_primary_10_1016_j_omtn_2024_102379 crossref_primary_10_4252_wjsc_v17_i4_102482 crossref_primary_10_1016_j_isci_2025_113445 crossref_primary_10_1016_j_tox_2024_154042 crossref_primary_10_1016_j_biopha_2024_116880 crossref_primary_10_1007_s11427_024_2819_y crossref_primary_10_1007_s00210_025_03898_2 crossref_primary_10_3389_frpro_2024_1320917 crossref_primary_10_1128_cmr_00022_23 crossref_primary_10_1261_rna_080220_124 crossref_primary_10_1016_j_metabol_2025_156153 crossref_primary_10_3390_ijms25137229 crossref_primary_10_4254_wjh_v17_i7_106795 crossref_primary_10_1371_journal_pone_0311212 crossref_primary_10_1093_nar_gkae1094 crossref_primary_10_3390_toxics13030167 crossref_primary_10_1016_j_compbiomed_2025_110771 crossref_primary_10_3390_ijms26020710 crossref_primary_10_1186_s12967_025_06629_6 crossref_primary_10_3390_life14121608 crossref_primary_10_1016_j_bios_2025_117422 crossref_primary_10_1007_s10142_025_01599_w crossref_primary_10_1097_BS9_0000000000000210 crossref_primary_10_1016_j_lanmic_2025_101155 crossref_primary_10_1016_j_gde_2025_102339 crossref_primary_10_31083_j_fbl2908292 crossref_primary_10_1016_j_csbj_2025_04_040 crossref_primary_10_1161_HYPERTENSIONAHA_124_21728 crossref_primary_10_1371_journal_pone_0314733 crossref_primary_10_3390_ijms25084301 crossref_primary_10_6023_A24090258 crossref_primary_10_3390_ijms252312979 crossref_primary_10_1016_j_gene_2025_149635 crossref_primary_10_17816_onco637142 crossref_primary_10_1038_s41598_025_00343_5 crossref_primary_10_3390_ijms26178633 crossref_primary_10_1016_j_micpath_2025_107646 crossref_primary_10_1039_D5AN00707K crossref_primary_10_1016_j_biopha_2024_116984 crossref_primary_10_1007_s44446_025_00026_2 crossref_primary_10_1007_s00604_024_06920_1 crossref_primary_10_1002_adhm_202402933 crossref_primary_10_1080_10408398_2025_2479066 crossref_primary_10_1016_j_nbas_2025_100141 crossref_primary_10_1016_j_jcyt_2025_05_010 crossref_primary_10_1038_s41422_024_00975_8 crossref_primary_10_1016_j_exer_2024_110180 crossref_primary_10_3390_cimb47060473 crossref_primary_10_1021_acssensors_5c01842 crossref_primary_10_1111_bph_17308 crossref_primary_10_1016_j_preme_2025_100023 crossref_primary_10_3390_ijms25137123 crossref_primary_10_1021_acssensors_5c00758 crossref_primary_10_2147_IJN_S487097 crossref_primary_10_1002_smll_202402914 crossref_primary_10_1038_s41598_024_62064_5 crossref_primary_10_1016_j_bios_2025_117445 crossref_primary_10_1016_j_bios_2025_117565 crossref_primary_10_1002_wrna_1832 crossref_primary_10_1124_molpharm_124_000895 crossref_primary_10_1007_s00210_024_03603_9 crossref_primary_10_3389_fphar_2024_1467298 crossref_primary_10_3390_cimb47030170 crossref_primary_10_1007_s12602_024_10443_9 crossref_primary_10_1186_s40478_025_01950_z crossref_primary_10_1038_s41598_024_79224_2 crossref_primary_10_1038_s41598_025_04835_2 crossref_primary_10_3390_ijms251810135 crossref_primary_10_1016_j_vetmic_2025_110622 crossref_primary_10_1016_j_ejmech_2025_117676 crossref_primary_10_1016_j_omtn_2024_102262 crossref_primary_10_1093_g3journal_jkae178 crossref_primary_10_1016_j_pmpp_2025_102793 crossref_primary_10_3892_ijo_2025_5769 crossref_primary_10_3389_fmolb_2023_1308274 crossref_primary_10_1111_jre_13384 crossref_primary_10_1016_j_nantod_2025_102800 crossref_primary_10_3389_fevo_2024_1464506 crossref_primary_10_3390_ijms26094259 crossref_primary_10_1242_dev_204373 crossref_primary_10_1007_s12015_025_10866_z crossref_primary_10_3390_ncrna10050046 crossref_primary_10_1016_j_omtn_2025_102500 crossref_primary_10_1016_j_phrs_2025_107596 crossref_primary_10_3389_fphys_2025_1507059 crossref_primary_10_1016_j_biopha_2025_118452 crossref_primary_10_1038_s41378_025_00927_1 crossref_primary_10_1038_s41580_024_00805_0 crossref_primary_10_3390_cells13151289 crossref_primary_10_1016_j_cca_2025_120301 crossref_primary_10_2217_epi_2023_0365 crossref_primary_10_1038_s41380_025_02925_1 crossref_primary_10_3390_biomedicines12050962 crossref_primary_10_3389_fphar_2025_1532558 crossref_primary_10_3390_ijms26125629 crossref_primary_10_2147_IJN_S464403 crossref_primary_10_3389_fncel_2025_1457740 crossref_primary_10_1186_s13045_025_01726_x crossref_primary_10_1016_j_atherosclerosis_2024_118584 crossref_primary_10_1016_j_jad_2024_09_032 crossref_primary_10_1016_j_gendis_2025_101770 crossref_primary_10_1007_s00210_025_03934_1 crossref_primary_10_3390_ijms25052786 crossref_primary_10_1016_j_gendis_2025_101534 crossref_primary_10_1111_jre_13369 crossref_primary_10_3390_ijms26052044 crossref_primary_10_1007_s10495_025_02117_w crossref_primary_10_3389_fmolb_2025_1616221 crossref_primary_10_1038_s41598_025_08646_3 crossref_primary_10_5312_wjo_v16_i7_107045 crossref_primary_10_1158_1078_0432_CCR_24_2785 crossref_primary_10_1186_s13071_025_06689_z crossref_primary_10_1016_j_foodres_2025_117325 crossref_primary_10_1093_jleuko_qiaf021 crossref_primary_10_1016_j_pharmr_2025_100065 crossref_primary_10_1038_s41580_024_00818_9 crossref_primary_10_3389_fcvm_2024_1432468 crossref_primary_10_1002_mrd_70045 crossref_primary_10_1016_j_bios_2025_117924 crossref_primary_10_1007_s12672_025_02744_4 crossref_primary_10_1016_j_isci_2024_111359 crossref_primary_10_1016_j_ccr_2025_216821 crossref_primary_10_1016_j_cellsig_2025_112081 crossref_primary_10_1038_s41573_025_01237_x crossref_primary_10_3389_fncel_2025_1541885 crossref_primary_10_1097_MD_0000000000035918 crossref_primary_10_1016_j_ncrna_2024_08_006 crossref_primary_10_1039_D5AY00303B crossref_primary_10_2147_TACG_S444546 crossref_primary_10_3390_chemosensors13090343 crossref_primary_10_3389_fonc_2025_1534862 crossref_primary_10_1007_s12268_024_2358_8 crossref_primary_10_3389_fendo_2024_1444940 crossref_primary_10_1093_postmj_qgae201 crossref_primary_10_1007_s00210_024_03594_7 crossref_primary_10_1038_s41598_024_54997_8 crossref_primary_10_1016_j_actatropica_2024_107243 crossref_primary_10_1016_j_gene_2024_149186 crossref_primary_10_1186_s12964_024_01934_x crossref_primary_10_1111_pbi_70132 crossref_primary_10_3390_cells13151242 crossref_primary_10_1016_j_tibtech_2024_04_002 crossref_primary_10_3389_fphar_2025_1604711 crossref_primary_10_1093_plphys_kiae311 crossref_primary_10_1101_gad_352129_124 crossref_primary_10_1016_j_lfs_2024_122950 crossref_primary_10_1021_acs_analchem_5c04010 crossref_primary_10_3390_ijms26094287 crossref_primary_10_3390_ijms26094288 crossref_primary_10_1186_s12859_024_05840_4 crossref_primary_10_3748_wjg_v30_i22_2843 crossref_primary_10_4252_wjsc_v17_i3_99472 crossref_primary_10_1002_adma_202501378 crossref_primary_10_1038_s41598_024_80708_4 crossref_primary_10_3748_wjg_v31_i24_104437 crossref_primary_10_1007_s12672_025_03234_3 crossref_primary_10_3390_ijms25115961 crossref_primary_10_1016_j_cca_2023_117610 crossref_primary_10_1186_s12284_024_00748_2 crossref_primary_10_1371_journal_ppat_1012789 crossref_primary_10_3390_ijms26104621 crossref_primary_10_1016_j_synbio_2025_03_011 crossref_primary_10_1016_j_redox_2025_103689 crossref_primary_10_1080_10985549_2025_2519156 crossref_primary_10_1186_s13287_025_04558_1 crossref_primary_10_1111_pce_15546 crossref_primary_10_3390_ijms25147686 crossref_primary_10_1186_s12951_025_03102_w crossref_primary_10_1021_acs_molpharmaceut_4c00871 crossref_primary_10_1080_21688370_2025_2502709 crossref_primary_10_1080_10715762_2025_2564674 crossref_primary_10_3389_fnmol_2024_1386735 crossref_primary_10_1186_s11658_024_00632_3 crossref_primary_10_1002_alr_23558 crossref_primary_10_1007_s11883_024_01216_4 crossref_primary_10_3390_plants13111429 crossref_primary_10_1038_s41576_024_00810_1 crossref_primary_10_1096_fj_202402248R crossref_primary_10_1002_chem_202402566 crossref_primary_10_1016_j_ajpath_2025_07_006 crossref_primary_10_3389_fmolb_2024_1368372 crossref_primary_10_20517_evcna_2025_47 crossref_primary_10_1016_j_virol_2024_110361 crossref_primary_10_1016_j_trac_2025_118397 crossref_primary_10_1016_j_ijbiomac_2025_147006 |
| ContentType | Journal Article |
| Copyright | 2023. Springer Nature Limited. Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| Copyright_xml | – notice: 2023. Springer Nature Limited. – notice: Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| DBID | CGR CUY CVF ECM EIF NPM 3V. 7QP 7QR 7RV 7TK 7TM 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. KB0 LK8 M0S M1P M7P NAPCQ P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI RC3 7X8 |
| DOI | 10.1038/s41576-023-00611-y |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database Neurosciences Abstracts Nucleic Acids Abstracts Health & Medical Collection (ProQuest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Biological Science Database Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | ProQuest Central Student MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: AUTh Library subscriptions: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1471-0064 |
| EndPage | 833 |
| ExternalDocumentID | 37380761 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA008748 – fundername: NIGMS NIH HHS grantid: R01 GM083300 |
| GroupedDBID | --- -DZ .55 0R~ 123 29M 36B 39C 4.4 53G 70F 7RV 7X7 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8R4 8R5 AARCD AAWYQ AAYZH ABAWZ ABDBF ABFSG ABJNI ABLJU ABUWG ACGFS ACIWK ACPRK ACSTC ACUHS ADBBV AENEX AEZWR AFANA AFBBN AFFNX AFHIU AFKRA AFSHS AGAYW AHBCP AHMBA AHOSX AHSBF AHWEU AIBTJ AIXLP ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS ALPWD ARMCB ASPBG ATHPR AVWKF AXYYD AZFZN B0M BBNVY BENPR BHPHI BKEYQ BKKNO BPHCQ BVXVI CCPQU CGR CS3 CUY CVF DB5 DU5 EAD EAP EBS ECM EE. EIF EJD EMB EMK EMOBN EPL ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA HCIFZ HMCUK HVGLF HZ~ IAO IGS IHR IHW INH INR ISR ITC LK8 M1P M7P N9A NAPCQ NFIDA NNMJJ NPM O9- ODYON PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO Q2X RIG RNR RNS RNT RNTTT SHXYY SIXXV SNYQT SOJ SV3 TAOOD TBHMF TDRGL TSG TUS UKHRP WOW X7M ~8M 3V. 7QP 7QR 7TK 7TM 7XB 88A 8FD 8FK AGSTI AZQEC DWQXO FR3 GNUQQ K9. P64 PKEHL PQEST PQUKI RC3 7X8 |
| ID | FETCH-LOGICAL-c419t-927a0430883e426b29561612b554f9bada2802e32c9d1b010ccfc2389b1b0bcd3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 531 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001018014400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1471-0056 1471-0064 |
| IngestDate | Sun Nov 09 12:15:43 EST 2025 Mon Oct 06 18:26:22 EDT 2025 Mon Jul 21 05:28:56 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | English |
| License | 2023. Springer Nature Limited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c419t-927a0430883e426b29561612b554f9bada2802e32c9d1b010ccfc2389b1b0bcd3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0002-8432-5851 0000-0001-5626-9656 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/11087887 |
| PMID | 37380761 |
| PQID | 2889800882 |
| PQPubID | 44267 |
| PageCount | 18 |
| ParticipantIDs | proquest_miscellaneous_2831295474 proquest_journals_2889800882 pubmed_primary_37380761 |
| PublicationCentury | 2000 |
| PublicationDate | 2023-12-01 |
| PublicationDateYYYYMMDD | 2023-12-01 |
| PublicationDate_xml | – month: 12 year: 2023 text: 2023-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Nature reviews. Genetics |
| PublicationTitleAlternate | Nat Rev Genet |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group |
| SSID | ssj0016173 |
| Score | 2.7555776 |
| SecondaryResourceType | review_article |
| Snippet | Ever since microRNAs (miRNAs) were first recognized as an extensive gene family >20 years ago, a broad community of researchers was drawn to investigate the... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 816 |
| SubjectTerms | Biosynthesis CRISPR Electron microscopy MicroRNAs MicroRNAs - genetics miRNA Transcriptome Transcriptomes |
| Title | microRNAs in action: biogenesis, function and regulation |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37380761 https://www.proquest.com/docview/2889800882 https://www.proquest.com/docview/2831295474 |
| Volume | 24 |
| WOSCitedRecordID | wos001018014400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT8IwEL8oaOKL3x8okpn4aMO6AW19MUggvrgQooY30nbF8OBABib8995tA5_0xZdLui7L0lzvfr273g_gVnFlYkutL2NjWMNxznRTGNzx0mrpmsLXNiObEFEkh0PVLwJuaVFWubaJmaGOp5Zi5PVASoXgBgHhw-yTEWsUZVcLCo1tKFOXhDAr3etvsgitPMPM0QAz6nlZXJrxQ1lP0XEJKr8NGXlxzla_Q8zM1fQO_vuTh7BfgEyvnWvFEWy55Bh2c9rJ1QnID6rCG0Tt1JskXn6z4d4zk-k7Gb5JeueRt6Onnk5ib57T1ePwFF573ZfOEysYFJhtcLVgKhCamnpJGTp0xSaga6yIaQyCiLEyOtaB9AMXBlbF3ODRzNqxRSeuDI6MjcMzKCXTxF2AJ41GeKSML8e60Woa42vfxXiWFZa3xi6oQHW9JKNiG6Sjn_WowM1mGhWYshI6cdMlvRNySjaKRgXO82UfzfJOGyNqu0SBlsu_P34Fe8QCn1eZVKG0mC_dNezYr8UknddgWwzeSA5FJiVK2eE1KD92o_6glukMyqj__A0aUcOu |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3JTsMwEB1BAcGFfSmrkeCGRey0jY2EEGIRCKgQAsQt2I6LeiAtTQH1p_hGZpoUTnDjwDGJZUWe8byxZ3kAW1pomzhqfZlYyyteCG6qkcUdr5xRvhoFxvXJJqJ6XT086Osh-BjUwlBa5cAm9g110nJ0R74rldLo3KBDeNB-4cQaRdHVAYVGrhYXvveOR7Zs__wY5bst5enJ7dEZL1gFuKsI3eVaRoYaXSkVeoQnK6m0E3HeIrA2tDWJkSqQPpROJ8LiccW5hkNg0xafrEtCnHcYRtCOC0ohi27uv6IWtTyiLdDgc-qxWRTpBKHazRAoI0r3DTl5DYL3fnZp-9B2OvXfFmUaJgsnmh3mWj8DQz6dhbGcVrM3B-qZsgxv6ocZa6Ysr9zYY7bZeiLD3sx2GKE5vWUmTVjHPxUcZvNw9ye_vQCltJX6JWDKGnT_tA1Uw1RqVWsDE_gEz-qRE7WGl2VYHYggLrZ5Fn-vfxk2vz7jBqWoi0l965XGhIKCqVGlDIu5mON23kkkprZSdJG0_PvkGzB-dnt1GV-e1y9WYIIY7_OMmlUodTuvfg1G3Vu3mXXW-_rI4PGvZf0J1esYuQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LS8NAEB5848X3oz5X0JtLk03b7AoiohZFKSIK3uLuZlN6MNWmVfrX_HXOJKme9ObBYx4sIfP4Zna_mQHYV74ysaXWl7ExvOZ8n-t6aNDipdXS1UNP23zYRNhqycdHdTsGH6NaGKJVjnxi7qjjrqU98qqQUmFwgwFhNSlpEbfnzZOXV04TpOikdTROo1CRazd8x_QtO746R1kfCNG8uD-75OWEAW5rvupzJUJNTa-kDBxClRFU5omYbxBkE2V0rIX0hAuEVbFvMHWxNrEIcsrglbFxgOuOw2QYoBZTlfrZF72E0oac3I_On1O_zbJgxwtkNUPQDIn6G3CKIHw-_Dm8zWGuOf-ff9ACzJXBNTstrGERxly6BNPFuM3hMshnYh_etU4z1klZUdFxxEyn2yaH38kOGaE83WU6jVnPtcvZZivw8CefvQoTaTd168Ck0RgWKuPJRNcadWM87bkYc_jQ-o3EiQpsjcQRleafRd-yqMDe12M0XDqN0anrDuidwKdD1rBWgbVC5NFL0WEkonZTtMG08fviuzCDIo5urlrXmzArSKFyos0WTPR7A7cNU_at38l6O7lqMnj6a1F_AqEjIRQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=microRNAs+in+action%3A+biogenesis%2C+function+and+regulation&rft.jtitle=Nature+reviews.+Genetics&rft.au=Shang%2C+Renfu&rft.au=Lee%2C+Seungjae&rft.au=Senavirathne%2C+Gayan&rft.au=Lai%2C+Eric+C&rft.date=2023-12-01&rft.pub=Nature+Publishing+Group&rft.issn=1471-0056&rft.eissn=1471-0064&rft.volume=24&rft.issue=12&rft.spage=816&rft.epage=833&rft_id=info:doi/10.1038%2Fs41576-023-00611-y&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-0056&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-0056&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-0056&client=summon |