Strong Predictive Algorithm of Pathogenesis-Based Biomarkers Improves Parkinson’s Disease Diagnosis

Easily accessible and accurate biomarkers can aid Parkinson’s disease diagnosis. We investigated whether combining plasma levels of α-synuclein, anti-α-synuclein, and/or their ratios to amyloid beta-40 correlated with clinical diagnosis. The inclusion of amyloid beta-40 (Aβ40) is novel. Plasma level...

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Bibliographic Details
Published in:	Molecular neurobiology Vol. 59; no. 3; pp. 1476 - 1485
Main Authors:	Chan, Daniel Kam Yin, Braidy, Nady, Chen, Ren Fen, Xu, Ying Hua, Bentley, Steven, Lubomski, Michal, Davis, Ryan L., Chen, Jack, Sue, Carolyn M., Mellick, George D.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.03.2022 Springer Nature B.V
Subjects:	Adult Aged Aged, 80 and over Algorithms alpha-Synuclein Amyloid beta-Peptides Biomarkers Biomedical and Life Sciences Biomedicine Cell Biology Diagnosis Female Humans Male Medical diagnosis Middle Aged Movement disorders Neurobiology Neurodegenerative diseases Neurology Neurosciences Parkinson Disease - diagnosis Parkinson's disease Pathogenesis Plasma levels ROC Curve Synuclein Biomarkers Amyloid-beta40 Diagnosis Parkinson’s disease Alpha-synuclein
ISSN:	0893-7648, 1559-1182, 1559-1182
Online Access:	Get full text
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