Screening for potential hazard effects from four nitramines on human eye and skin

► Four nitramines were investigated for toxic effects on in vitro skin and eye models. ► 2-Methyl-2-(nitroamino)-1-propanol, methyl- and ethanolnitramine were very severe irritants to eye. ► Dimethylnitramine was observed to be a mild eye irritant. ► Methyl- and ethanolnitramine were tested for skin...

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Bibliographic Details
Published in:	Toxicology in vitro Vol. 27; no. 4; pp. 1205 - 1210
Main Authors:	Fjellsbø, Lise Marie, Van Rompay, An R., Hooyberghs, Jef, Nelissen, Inge, Dusinska, Maria
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2013
Subjects:	acute exposure amines Aniline Compounds - toxicity Animals Carbon dioxide Cattle cornea Corneal Opacity - chemically induced corrosion Cyclic AMP Response Element Modulator - genetics Dimethylamines - toxicity Eye - anatomy & histology Eye - drug effects Eye - metabolism eye irritation Eye irritation test Gene Expression Regulation - drug effects human health Human in vitro tests Humans In Vitro Techniques Nitramines Nitrobenzenes - toxicity nitrosamines opacity permeability Permeability - drug effects Receptors, CCR2 - genetics screening Skin - drug effects Skin - metabolism Skin corrosion test skin irritation Skin irritation test Skin sensitization test Skin Tests Nitramines Human in vitro tests Skin irritation test Skin corrosion test Skin sensitization test Eye irritation test
ISSN:	0887-2333, 1879-3177, 1879-3177
Online Access:	Get full text
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