Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity

Cancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103 + T cells have been associated with better clinical prognosis in patients with cancer. However, the specific im...

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Bibliographic Details
Published in:	Nature immunology Vol. 25; no. 5; pp. 834 - 846
Main Authors:	Hamid, Megat H. B. A., Cespedes, Pablo F., Jin, Chen, Chen, Ji-Li, Gileadi, Uzi, Antoun, Elie, Liang, Zhu, Gao, Fei, Teague, Renuka, Manoharan, Nikita, Maldonado-Perez, David, Khalid-Alham, Nasullah, Cerundolo, Lucia, Ciaoca, Raul, Hester, Svenja S., Pinto-Fernández, Adán, Draganov, Simeon D., Vendrell, Iolanda, Liu, Guihai, Yao, Xuan, Kvalvaag, Audun, Dominey-Foy, Delaney C. C., Nanayakkara, Charunya, Kanellakis, Nikolaos, Chen, Yi-Ling, Waugh, Craig, Clark, Sally-Ann, Clark, Kevin, Sopp, Paul, Rahman, Najib M., Verrill, Clare, Kessler, Benedikt M., Ogg, Graham, Fernandes, Ricardo A., Fisher, Roman, Peng, Yanchun, Dustin, Michael L., Dong, Tao
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2024 Nature Publishing Group
Subjects:	631/250/1619/554 631/250/2152/1566/1618 631/250/580 Animals Antigens Antigens, CD - immunology Antigens, CD - metabolism Antitumor activity Apyrase Biomedical and Life Sciences Biomedicine Cancer Cancer therapies CD103 antigen Cell Line, Tumor Cell therapy Cytotoxicity Cytotoxicity, Immunologic Humans Immunology Immunotherapy Infectious Diseases Integrin alpha Chains - metabolism Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Mice Neoplasms - immunology Neoplasms - therapy Phenotypes Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology T-Lymphocytes, Cytotoxic - immunology
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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