Lung function trajectories in health and disease

The normal lung function trajectory from birth to death has three phases: a growth phase (from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline phase resulting from physiological lung ageing. Numerous genetic and environmental factors can alter one or more of th...

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Bibliographic Details
Published in:The lancet respiratory medicine Vol. 7; no. 4; p. 358
Main Authors: Agusti, Alvar, Faner, Rosa
Format: Journal Article
Language:English
Published: England 01.04.2019
Subjects:
Adult
Asthma
Child
Forced Expiratory Volume
Humans
Lung
Research Design
ISSN:2213-2619, 2213-2619
Online Access:Get more information
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Summary:The normal lung function trajectory from birth to death has three phases: a growth phase (from birth to early adulthood), a plateau phase (that lasts for a few years), and a decline phase resulting from physiological lung ageing. Numerous genetic and environmental factors can alter one or more of these phases. Evidence shows that several lung function trajectories exist throughout the life course and, importantly, that some of them are associated with substantial implications for health and disease. Here, we review the evidence, formulate a series of questions, and identify various challenges that need to be addressed to identify potential opportunities to promote respiratory health.
Bibliography:ObjectType-Article-1
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ISSN:2213-2619
2213-2619
DOI:10.1016/S2213-2600(18)30529-0